Search Results - "Roos, I. A. G"

The binding of binuclear platinum(II)-terpyridine complexes to DNA by McFadyen, W D, Wakelin, L P, Roos, I A, Hillcoat, B L

“…The binding of platinum (II)-terpyridine complexes to DNA was studied by using equilibrium dialysis. Optical absorption methods were used to measure the…”
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Binuclear platinum (II)-terpyridine complexes. A new class of bifunctional DNA-intercalating agent by McFadyen, W D, Wakelin, L P, Roos, I A, Hillcoat, B L

“…A series of binuclear DNA-binding ligands was prepared by linking two (2,2':6',2"-terpyridine)platinum(II) moieties via alpha omega-dithiols of the type…”
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Interaction of platinum compounds with dinucleotides by Roos, I. A. G, Thomson, A. J, Mansy, S

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cis-Bis(pyridine)platinum(II) organoamides with unexpected growth inhibition properties and antitumor activity by Webster, Lorraine K, Deacon, Glen B, Buxton, David P, Hillcoat, Brian L, James, Alison M, Roos, Ian A. G, Thomson, Robin J, Wakelin, Laurence P. G, Williams, Tracey L

“…The platinum(II) organoamides [Pt(NRCH2)2L2] (L = pyridine (py), R = p-HC6F4, C6F5,p-IC6F4,p-CIC6F4,p-C6F5C6F4; L = 4-methylpyridine, R = p-HC6F4) and…”
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Metallothionein induction in mouse tissues by cis-dichlorodiammineplatinum(II) and its hydrolysis products by Farnworth, P G, Hillcoat, B L, Roos, I A

“…cis-Dichlorodiammineplatinum(II) (cis-DDP) doubled the amount of metallothioneins (MTs) in the livers and kidneys of BALB/c mice when injected i.p. in a single…”
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Activity of platinum (II) intercalating agents against murine leukemia L 1210 by MCFAYDEN, W. D, WAKELIN, L. P. G, ROOS, I. A. G, LEOPOLD, V. A

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Interaction of phenylthiolato-(2,2',2"-terpyridine)platinum(II) cation with DNA by Wakelin, L P, McFadyen, W D, Walpole, A, Roos, I A

“…The interaction between a novel aromatic thiolato derivative from the family of DNA-intercalating platinum complexes,…”
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Collection and analysis of kinetic data from a stopped-flow spectrophotometer using a microcomputer by Roos, I A, Wakelin, L P, Hakkennes, J, Coles, J

“…A method of interfacing an inexpensive microcomputer to a stopped-flow kinetics spectrophotometer is described. It allows software-selectable sampling…”
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Development of a murine gastric distension model for testing the emetic potential of new drugs and efficacy of antiemetics by Olver, I N, Roos, I A, Thomas, K, Hillcoat, B L

“…A small animal model for emesis would allow preclinical testing of antiemetics and new drugs. Mice treated with cisplatinum develop stomachs distended with…”
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Intracellular DNA damage produced by a series of diacridines by Roos, I A, Wakelin, L P, Henry, S J

“…The intracellular DNA damage produced by a series of diacridines after a 2 h pulse treatment of L1210 cells in culture was investigated by using the…”
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