Search Results - "Roop, Dennis"

Loricrin: Past, Present, and Future by Ishitsuka, Yosuke, Roop, Dennis R

“…The terminal differentiation of the epidermis is a complex physiological process. During the past few decades, medical genetics has shown that defects in the…”
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Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration by Li, Fang, Huang, Qian, Chen, Jiang, Peng, Yuanlin, Roop, Dennis R, Bedford, Joel S, Li, Chuan-Yuan

“…The ability to regenerate damaged tissues is a common characteristic of multicellular organisms. We report a role for apoptotic cell death in promoting wound…”
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Loricrin Confers Photoprotective Function against UVB in Corneocytes by Ishitsuka, Yosuke, Roop, Dennis R.

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High-efficiency RNA-based reprogramming of human primary fibroblasts by Kogut, Igor, McCarthy, Sandra M., Pavlova, Maryna, Astling, David P., Chen, Xiaomi, Jakimenko, Ana, Jones, Kenneth L., Getahun, Andrew, Cambier, John C., Pasmooij, Anna M. G., Jonkman, Marcel F., Roop, Dennis R., Bilousova, Ganna

“…Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine; however, their potential clinical application is hampered by the low…”
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Mechanisms regulating epithelial stratification by Koster, Maranke I, Roop, Dennis R

“…The epidermis is a stratified epithelium that functions as a barrier protecting the organism from dehydration, mechanical trauma, and microbial insults. This…”
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ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic Targets by Luo, Yuchun, Dallaglio, Katiuscia, Chen, Ying, Robinson, William A., Robinson, Steven E., McCarter, Martin D., Wang, Jianbin, Gonzalez, Rene, Thompson, David C., Norris, David A., Roop, Dennis R., Vasiliou, Vasilis, Fujita, Mayumi

“…Although the concept of cancer stem cells (CSCs) is well‐accepted for many tumors, the existence of such cells in human melanoma has been the subject of…”
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Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage by Bilousova, Ganna, Chen, Jiang, Roop, Dennis R.

“…Recent breakthroughs in the generation of induced pluripotent stem cells (iPSCs) have provided a novel renewable source of cells with embryonic stem cell-like…”
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Differentiation of human induced pluripotent stem cells into a keratinocyte lineage by Kogut, Igor, Roop, Dennis R, Bilousova, Ganna

“…Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides an opportunity to develop novel personalized treatment options for…”
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Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis by Zhang, Lei, Ferreyros, Michael, Feng, Weiguo, Hupe, Melanie, Crumrine, Debra A, Chen, Jiang, Elias, Peter M, Holleran, Walter M, Niswander, Lee, Hohl, Daniel, Williams, Trevor, Torchia, Enrique C, Roop, Dennis R

“…Harlequin Ichthyosis is a severe skin disease caused by mutations in the human gene encoding ABCA12. Here, we characterize a novel mutation in intron 29 of the…”
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Trends in Regenerative Medicine: Repigmentation in Vitiligo Through Melanocyte Stem Cell Mobilization by Birlea, Stanca A., Costin, Gertrude‐E., Roop, Dennis R., Norris, David A.

“…Vitiligo is the most frequent human pigmentary disorder, characterized by progressive autoimmune destruction of mature epidermal melanocytes. Of the current…”
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Tracing the Equilibrium Phase of Cancer Immunoediting in Epidermal Neoplasms via Longitudinal Intravital Imaging by Kubick, Bradley J., Fan, Xiying, Crouch, Acacia, McCarthy, Riley, Roop, Dennis R.

“…Recognition of transformed cells by the immune system can sometimes generate a rate-limiting equilibrium phase, wherein tumor outgrowth is prevented without…”
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Loricrin at the Boundary between Inside and Outside by Ishitsuka, Yosuke, Roop, Dennis R

“…Cornification is a specialized mode of the cell-death program exclusively allowed for terrestrial amniotes. Recent investigations suggest that loricrin (LOR)…”
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Loricrin Protects against Chemical Carcinogenesis by Ogawa, Tatsuya, Ishitsuka, Yosuke, Nakamura, Yoshiyuki, Watanabe, Rei, Okiyama, Naoko, Fujisawa, Yasuhiro, Fujimoto, Manabu, Roop, Dennis R., Nomura, Toshifumi

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NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy by Ogawa, Tatsuya, Ishitsuka, Yosuke, Nakamura, Yoshiyuki, Kubota, Noriko, Saito, Akimasa, Fujisawa, Yasuhiro, Watanabe, Rei, Okiyama, Naoko, Suga, Yasushi, Roop, Dennis R, Fujimoto, Manabu

“…Atopic dermatitis is a chronic form of allergic contact dermatitis that is closely associated with a compromised epidermal barrier. Immunogenicity of a given…”
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The Epidermis: Redox Governor of Health and Diseases by Ishitsuka, Yosuke, Roop, Dennis R

“…A functional epithelial barrier necessitates protection against dehydration, and ichthyoses are caused by defects in maintaining the permeability barrier in…”
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Harnessing the Power of Regenerative Therapy for Vitiligo and Alopecia Areata by Barbulescu, Chauncey C., Goldstein, Nathaniel B., Roop, Dennis R., Norris, David A., Birlea, Stanca A.

“…Vitiligo and alopecia areata (AA) are common autoimmune conditions characterized by white spots on the skin (vitiligo) and bald spots on the scalp (AA), which…”
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Amniotic Fluid Activates the Nrf2/Keap1 Pathway to Repair an Epidermal Barrier Defect In Utero by Huebner, Aaron J., Dai, Daisy, Morasso, Maria, Schmidt, Edward E., Schäfer, Matthias, Werner, Sabine, Roop, Dennis R.

“…The loss of loricrin, a major component of the cornified envelope, results in a delay of epidermal barrier formation. Therefore, the living layers of the…”
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Horizontal Basal Cells Are Multipotent Progenitors in Normal and Injured Adult Olfactory Epithelium by Iwai, Naomi, Zhou, Zhijian, Roop, Dennis R., Behringer, Richard R.

“…The mammalian olfactory neuroepithelium provides a unique system for understanding the regulation of neurogenesis by adult neural stem cells. Recently, mouse…”
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Osteoblasts Derived from Induced Pluripotent Stem Cells form Calcified Structures in Scaffolds Both In Vitro and In Vivo by Bilousova, Ganna, Jun, Du Hyun, King, Karen B., De Langhe, Stijn, Chick, Wallace S., Torchia, Enrique C., Chow, Kelsey S., Klemm, Dwight J., Roop, Dennis R., Majka, Susan M.

“…Reprogramming somatic cells into an ESC‐like state, or induced pluripotent stem (iPS) cells, has emerged as a promising new venue for customized cell…”
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A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity by Kumar, Vinod, Bouameur, Jamal-Eddine, Bär, Janina, Rice, Robert H, Hornig-Do, Hue-Tran, Roop, Dennis R, Schwarz, Nicole, Brodesser, Susanne, Thiering, Sören, Leube, Rudolf E, Wiesner, Rudolf J, Vijayaraj, Preethi, Brazel, Christina B, Heller, Sandra, Binder, Hans, Löffler-Wirth, Henry, Seibel, Peter, Magin, Thomas M

“…Keratin intermediate filaments (KIFs) protect the epidermis against mechanical force, support strong adhesion, help barrier formation, and regulate growth. The…”
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