Search Results - "Rook, Graham A"

Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health by Rook, Graham A.

“…Epidemiological studies suggest that living close to the natural environment is associated with long-term health benefits including reduced death rates,…”
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Hygiene Hypothesis and Autoimmune Diseases by Rook, Graham A. W.

“…Throughout the twentieth century, there were striking increases in the incidences of many chronic inflammatory disorders in the rich developed countries. These…”
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Regulation of inflammation by interleukin-4: a review of “alternatives” by Luzina, Irina G., Keegan, Achsah D., Heller, Nicola M., Rook, Graham A. W., Shea‐Donohue, Terez, Atamas, Sergei P.

“…Review on three IL‐4‐related branch points for immune regulation: alternative splicing of IL‐4, differential receptor engagement, and differential regulation…”
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Infection, immunoregulation, and cancer by Rook, Graham A.W, Dalgleish, Angus

“…As man has moved rapidly from the hunter-gatherer environment to the living conditions of the industrialized countries, the incidences of some cancers have…”
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Review series on helminths, immune modulation and the hygiene hypothesis: The broader implications of the hygiene hypothesis by Rook, Graham A.W

“…Man has moved rapidly from the hunter-gatherer environment to the living conditions of the rich industrialized countries. The hygiene hypothesis suggests that…”
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Evolution, the Immune System, and the Health Consequences of Socioeconomic Inequality by Rook, Graham A W

“…Healthy development and function of essentially all physiological systems and organs, including the brain, require exposure to the microbiota of our mothers…”
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Microbial 'Old Friends', immunoregulation and stress resilience by Rook, Graham A W, Lowry, Christopher A, Raison, Charles L

“…Chronic inflammatory diseases (autoimmunity, allergy and inflammatory bowel diseases) are increasing in prevalence in urban communities in high-income…”
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The old friends hypothesis: evolution, immunoregulation and essential microbial inputs by Rook, Graham A. W.

“…In wealthy urbanised societies there have been striking increases in chronic inflammatory disorders such as allergies, autoimmunity and inflammatory bowel…”
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Lung Remodeling in Pulmonary Tuberculosis by Dheda, Keertan, Booth, Helen, Huggett, Jim F., Johnson, Margaret A., Zumla, Alimuddin, Rook, Graham A. W.

“…Tuberculosis is a global public health catastrophe responsible for >8 million cases of illness and 2 million deaths annually. Pulmonary cavitation with…”
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Microbial exposures that establish immunoregulation are compatible with targeted hygiene by Rook, Graham A.W., Bloomfield, Sally F.

“…It is often suggested that hygiene is not compatible with the microbial exposures that are necessary for establishment of the immune system in early life…”
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Immune responses to tuberculosis in developing countries: implications for new vaccines by Zumla, Alimuddin, Rook, Graham A. W, Dheda, Keertan

“…Tuberculosis is out of control in developing countries, where it is killing millions of people every year. In these areas, the present vaccine - Mycobacterium…”
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Can we vaccinate against depression? by Rook, Graham A.W., Raison, Charles L., Lowry, Christopher A.

“…► Microorganisms and microbiota with which we coevolved are essential for the induction of immunoregulation. ► Depletion of these organisms by modern life is…”
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The Microbiota, Immunoregulation, and Mental Health: Implications for Public Health by Lowry, Christopher A., Smith, David G., Siebler, Philip H., Schmidt, Dominic, Stamper, Christopher E., Hassell, James E., Yamashita, Paula S., Fox, James H., Reber, Stefan O., Brenner, Lisa A., Hoisington, Andrew J., Postolache, Teodor T., Kinney, Kerry A., Marciani, Dante, Hernandez, Mark, Hemmings, Sian M. J., Malan-Muller, Stefanie, Wright, Kenneth P., Knight, Rob, Raison, Charles L., Rook, Graham A. W.

“…The hygiene or “Old Friends” hypothesis proposes that the epidemic of inflammatory disease in modern urban societies stems at least in part from reduced…”
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Th2 cytokines in susceptibility to tuberculosis by Rook, Graham A W

“…We need to understand what is different about susceptibility to tuberculosis (TB) in developing countries where most TB occurs, and where the current vaccine,…”
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Tuberculosis Due to High-Dose Challenge in Partially Immune Individuals: A Problem for Vaccination? by Rook, Graham A. W., Hernández-Pando, Rogelio, Zumla, Alimuddin

“…The currently available vaccine for tuberculosis (TB) is ineffective in developing countries. We need to understand the pathogenesis of TB in those countries…”
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Mechanisms of Disease: the hygiene hypothesis revisited by Guarner, Francisco, Bourdet-Sicard, Raphaëlle, Brandtzaeg, Per, Gill, Harsharnjit S, McGuirk, Peter, van Eden, Willem, Versalovic, James, Weinstock, Joel V, Rook, Graham AW

“…In industrialized countries the incidence of diseases caused by immune dysregulation has risen. Epidemiologic studies initially suggested this was connected to…”
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Association of the Salivary Microbiome With Animal Contact During Early Life and Stress-Induced Immune Activation in Healthy Participants by Langgartner, Dominik, Zambrano, Cristian A, Heinze, Jared D, Stamper, Christopher E, Böbel, Till S, Hackl, Sascha B, Jarczok, Marc N, Rohleder, Nicolas, Rook, Graham A, Gündel, Harald, Waller, Christiane, Lowry, Christopher A, Reber, Stefan O

“…The prevalence of stress-associated somatic and psychiatric disorders is increased in environments offering a narrow relative to a wide range of microbial…”
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The hygiene hypothesis and psychiatric disorders by Rook, Graham A.W, Lowry, Christopher A

“…The hygiene hypothesis proposes that several chronic inflammatory disorders (allergies, autoimmunity, inflammatory bowel disease) are increasing in prevalence…”
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Immunotherapeutics for Tuberculosis in Experimental Animals: Is There a Common Pathway Activated by Effective Protocols? by Rook, Graham A. W., Lowrie, Douglas B., Hernández-Pando, Rogelio

“…The increasing threat posed by drug-resistant strains of M. tuberculosis is leading to a reappraisal of the possibility of treating tuberculosis (TB) by…”
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Evolution and the critical role of the microbiota in the reduced mental and physical health associated with low socioeconomic status (SES) by Rook, Graham A.W.

“…The evolution of the gut-microbiota-brain axis in animals reveals that microbial inputs influence metabolism, the regulation of inflammation and the…”
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