Search Results - "Roof, Robin L."

Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progesterone by Roof, R L, Hall, E D

“…Increasing evidence has demonstrated striking sex differences in the pathophysiology of and outcome after acute neurological injury. Lesser susceptibility to…”
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Estrogen-related gender difference in survival rate and cortical blood flow after impact-acceleration head injury in rats by Roof, R L, Hall, E D

“…While a number of laboratories have begun to examine gender differences in outcome following experimental stroke, little is known about the relative response…”
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A comparison of long-term functional outcome after 2 middle cerebral artery occlusion models in rats by ROOF, Robin L, SCHIELKE, Gerald P, XIAODAN REN, HALL, Edward D

“…Proven behavioral assessment strategies for testing potential therapeutic agents in rat stroke models are needed. Few studies include tasks that demand higher…”
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Gender differences in Morris water maze performance depend on task parameters by Roof, Robin L, Stein, Donald G

“…This study demonstrates that the relative performance of male and female rats on a Morris water maze task changes when the task parameters are varied. In three…”
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Declines in cognitive and sensorimotor function in tg4510 mutant mouse by Roof, Robin L, McCarthy, Sheryl, Moore, Christopher, Brown, Tracy, Richter, Karl, Hicks, Carol

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Synthesis and SAR of tolylamine 5-HT6 antagonists by SINGER, Jamie M, WILSON, Michael W, ROUSH, Nicole, CAMPBELL, Jeffrey E, SU, Ti-Zhi, HURST, Susan I, STONER, Chad L, SCHWARZ, Jacob B, JOHNSON, Paul D, GRAHAM, Shelley R, COOKE, Leonard W, ROOF, Robin L, BOXER, Peter A, GOLD, Lisa H, MELTZER, Leonard T, JANSSEN, Ann

“…The synthesis and SAR of tolylamines with 5-HT(6) receptor antagonist activity is presented. The amine, core aromatic, peripheral aromatic, and ether linker…”
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Transgene dependent, doxycycline-sensitive cognitive deficits in Tg4510 mutant mouse correlate with insoluble tau epitope accumulation by Roof, Robin L, Yabe, Yoko, Brown, Tracy M, McCarthy, Sheryl A, Bales, Kelly R, Hicks, Carol D

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The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases by Hu, Lain-Yen, Boxer, Peter A., Kesten, Suzanne R., Lei, Huangshu J., Wustrow, David J., Moreland, David W., Zhang, Liming, Ahn, Kay, Ryder, Todd R., Liu, Xiaohong, Rubin, John R., Fahnoe, Kelly, Carroll, Richard T., Dutta, Satavisha, Fahnoe, Douglass C., Probert, Albert W., Roof, Robin L., Rafferty, Michael F., Kostlan, Catherine R., Scholten, Jeffrey D., Hood, Molly, Ren, Xiao-Dan, Schielke, Gerald P., Su, Ti-Zhi, Taylor, Charles P., Mistry, Anil, McConnell, Patrick, Hasemann, Charles, Ohren, Jeffrey

“…The SAR and pharmacological profile of a series of BCATc inhibitors is described. The inhibition of the cytosolic isoenzyme BCAT that is expressed specifically…”
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Progesterone protects against lipid peroxidation following traumatic brain injury in rats by Roof, R L, Hoffman, S W, Stein, D G

“…The gonadal hormone, progesterone, has been shown to have neuroprotective effects in injured nervous system, including the severity of postinjury cerebral…”
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Blood-brain barrier breakdown and edema formation following frontal cortical contusion: does hormonal status play a role? by Duvdevani, R, Roof, R L, Fülöp, Z, Hoffman, S W, Stein, D G

“…The present experiment was designed to evaluate and correlate the time course of blood-brain barrier (BBB) integrity and cerebral edema in adult male rats…”
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GENDER DIFFERENCES IN CNS TRAUMA AND STROKE: 292 by Roof, Robin L.

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Neonatal exogenous testosterone modifies sex difference in radial arm and Morris water maze performance in prepubescent and adult rats by Roof, R L

“…To study the involvement of testosterone in the development of spatial abilities, testosterone propionate (TP) was administered to male and female rats during…”
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Progesterone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats by Roof, R L, Duvdevani, R, Braswell, L, Stein, D G

“…The ability of progesterone to reduce the cerebral edema associated with traumatic brain damage first became apparent when we observed that males had…”
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P1‐146: Transgene dependent, doxycycline‐sensitive cognitive deficits in Tg4510 mutant mouse correlate with insoluble tau epitope accumulation by Roof, Robin L., Yabe, Yoko, Brown, Tracy M., McCarthy, Sheryl A., Bales, Kelly R., Hicks, Carol D.

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P4‐007: Declines in cognitive and sensorimotor function in tg4510 mutant mouse by Roof, Robin L., McCarthy, Sheryl, Moore, Christopher, Brown, Tracy, Richter, Karl, Hicks, Carol

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Progesterone Rapidly Decreases Brain Edema: Treatment Delayed up to 24 Hours Is Still Effective by Roof, Robin L., Duvdevani, Revital, Heyburn, John W., Stein, Donald G.

“…Cerebral edema is a serious side effect of traumatic brain injury. We have previously established that progesterone injections, initiated within 1 h after…”
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Testosterone improves maze performance and induces development of a male hippocampus in females by Roof, R L, Havens, M D

“…In a combined behavioral and morphometric study, we observed a testosterone-related sexual dimorphism in the granule cell layer of the hippocampus of…”
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Gender influences outcome of brain injury: progesterone plays a protective role by Roof, R L, Duvdevani, R, Stein, D G

“…The contributions of gender and gonadal hormones in the cascade of events following brain injury are largely unexplored. We measured cerebral edema following…”
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Synthesis and SAR of tolylamine 5-HT 6 antagonists by Singer, Jamie M., Wilson, Michael W., Johnson, Paul D., Graham, Shelley R., Cooke, Leonard W., Roof, Robin L., Boxer, Peter A., Gold, Lisa H., Meltzer, Leonard T., Janssen, Ann, Roush, Nicole, Campbell, Jeffrey E., Su, Ti-Zhi, Hurst, Susan I., Stoner, Chad L., Schwarz, Jacob B.

“…The synthesis and SAR of tolylamines with 5-HT 6 receptor antagonist activity is presented. The amine, core aromatic, peripheral aromatic, and ether linker…”
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A reliable and sensitive enzyme immunoassay method for measuring 8-isoprostaglandin F 2α: a marker for lipid peroxidation after experimental brain injury by Hoffman, Stuart W., Roof, Robin L., Stein, Donald G.

“…The objectives of this study were to determine (1) if levels of 8-isoprostaglandin F 2α (8-isoPGF 2α), a non-enzymatically produced prostaglandin, were…”
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