Search Results - "Rood, Brian R"

Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors by Rivero-Hinojosa, Samuel, Grant, Melanie, Panigrahi, Aswini, Zhang, Huizhen, Caisova, Veronika, Bollard, Catherine M., Rood, Brian R.

“…Neoantigen discovery in pediatric brain tumors is hampered by their low mutational burden and scant tissue availability. Here we develop a proteogenomic…”
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MYC Drives Group 3 Medulloblastoma through Transformation of Sox2 + Astrocyte Progenitor Cells by Tao, Ran, Murad, Najiba, Xu, Zhenhua, Zhang, Peng, Okonechnikov, Konstantin, Kool, Marcel, Rivero-Hinojosa, Samuel, Lazarski, Christopher, Zheng, Pan, Liu, Yang, Eberhart, Charles G, Rood, Brian R, Packer, Roger, Pei, Yanxin

“…A subset of group 3 medulloblastoma frequently harbors amplification or overexpression of lacking additional focal aberrations, yet it remains unclear whether…”
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A Proteogenomic Approach to Understanding MYC Function in Metastatic Medulloblastoma Tumors by Staal, Jerome A, Pei, Yanxin, Rood, Brian R

“…Brain tumors are the leading cause of cancer-related deaths in children, and medulloblastoma is the most prevalent malignant childhood/pediatric brain tumor…”
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Advances in the proteomic investigation of the cell secretome by Brown, Kristy J, Formolo, Catherine A, Seol, Haeri, Marathi, Ramya L, Duguez, Stephanie, An, Eunkyung, Pillai, Dinesh, Nazarian, Javad, Rood, Brian R, Hathout, Yetrib

“…Studies of the cell secretome have greatly increased in recent years owing to improvements in proteomic platforms, mass spectrometry instrumentation and to the…”
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Cellular Therapy for Children with Central Nervous System Tumors: Mining and Mapping the Correlative Data by Crotty, Erin E., Wilson, Ashley L., Davidson, Tom, Tahiri, Sophia, Gust, Juliane, Griesinger, Andrea M., Venkataraman, Sujatha, Park, Julie R., Mueller, Sabine, Rood, Brian R., Hwang, Eugene I., Wang, Leo D., Vitanza, Nicholas A.

“…Purpose of Review Correlative studies should leverage clinical trial frameworks to conduct biospecimen analyses that provide insight into the bioactivity of…”
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HIC1 ( Hypermethylated in Cancer 1) epigenetic silencing in tumors by Fleuriel, Capucine, Touka, Majid, Boulay, Gaylor, Guérardel, Cateline, Rood, Brian R., Leprince, Dominique

“…HIC1 ( Hypermethylated in Cancer 1), as it name implied, was originally isolated as a new candidate tumor suppressor gene located at 17p13.3 because it resides…”
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Proteomic analysis of Medulloblastoma reveals functional biology with translational potential by Rivero-Hinojosa, Samuel, Lau, Ling San, Stampar, Mojca, Staal, Jerome, Zhang, Huizhen, Gordish-Dressman, Heather, Northcott, Paul A, Pfister, Stefan M, Taylor, Michael D, Brown, Kristy J, Rood, Brian R

“…Genomic characterization has begun to redefine diagnostic classifications of cancers. However, it remains a challenge to infer disease phenotypes from genomic…”
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Proteomic profiling of cerebrospinal fluid identifies prostaglandin D2 synthase as a putative biomarker for pediatric medulloblastoma: A pediatric brain tumor consortium study by Rajagopal, Meena U, Hathout, Yetrib, MacDonald, Tobey J, Kieran, Mark W, Gururangan, Sri, Blaney, Susan M, Phillips, Peter, Packer, Roger, Gordish-Dressman, Heather, Rood, Brian R

“…The aims of this study were to demonstrate the feasibility of centrally collecting and processing high-quality cerebrospinal fluid (CSF) samples for proteomic…”
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Scavenger Chemokine (CXC Motif) Receptor 7 (CXCR7) Is a Direct Target Gene of HIC1 (Hypermethylated in Cancer 1) by Van Rechem, Capucine, Rood, Brian R., Touka, Majid, Pinte, Sébastien, Jenal, Mathias, Guérardel, Cateline, Ramsey, Keri, Monté, Didier, Bégue, Agnès, Tschan, Mario P., Stephan, Dietrich A., Leprince, Dominique

“…The tumor suppressor gene HIC1 (Hypermethylated in Cancer 1) that is epigenetically silenced in many human tumors and is essential for mammalian development…”
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The Reelin receptors ApoER2 and VLDLR are direct target genes of HIC1 (Hypermethylated In Cancer 1) by Dubuissez, Marion, Faiderbe, Perrine, Pinte, Sébastien, Dehennaut, Vanessa, Rood, Brian R., Leprince, Dominique

“…•Overexpression of HIC1 in breast cancer cells reduces ApoER2 and VLDLR expression.•Knock-down of HIC1 in normal human fibroblasts increases ApoER2 and VLDLR…”
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The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells by Waye, Sarah, Naeem, Aisha, Choudhry, Muhammad Umer, Parasido, Erika, Tricoli, Lucas, Sivakumar, Angiela, Mikhaiel, John P, Yenugonda, Venkata, Rodriguez, Olga C, Karam, Sana D, Rood, Brian R, Avantaggiati, Maria Laura, Albanese, Chris

“…Medulloblastoma (MB), a primitive neuroectodermal tumor, is the most common malignant childhood brain tumor and remains incurable in about a third of patients…”
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Isolated extracranial recurrence of anaplastic ependymoma by Chao, Mwe Mwe, Packer, Roger J., Myseros, John S., Rood, Brian R.

“…Anaplastic ependymoma is a malignant glial tumor thought to arise from radial glial cells of the ventricular zone. Because ependymoma is frequently encountered…”
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Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer by Reva, Boris, Chowdhury, Shrabanti, Ji, Jiayi, Whiteaker, Jeffrey R., Colaprico, Antonio, Raman, Pichai, Guo, Yiran, Brown, Miguel A., Ivey, Richard G., Szpyt, John, Guha Thakurta, Sanjukta, Lopez, Gonzalo, Kalayci, Selim, Gümüş, Zeynep H., Yoo, Seungyeul, da Veiga Leprevost, Felipe, Katsnelson, Lizabeth, Wang, Ying, Kennedy, Jacob J., Voytovich, Uliana J., Zhao, Lei, Baubet, Valerie, Tauhid, Lamiya, Lilly, Jena V., Mason, Jennifer L., Farrow, Bailey, Young, Nathan, Leary, Sarah, Moon, Jamie, Petyuk, Vladislav A., Nazarian, Javad, Palmer, James N., Lober, Robert M., Rivero-Hinojosa, Samuel, Wang, Joshua M., Broberg, Matilda, Chu, Rosalie K., Moore, Ronald J., Monroe, Matthew E., Zhao, Rui, Zhu, Jun, Mesri, Mehdi, Boja, Emily, Hiltke, Tara, Rodriguez, Henry, Zhang, Bing, Mani, D.R., Iavarone, Antonio, Schürer, Stephan, Chen, Xi S., Heath, Allison P., Rokita, Jo Lynne, Nesvizhskii, Alexey I., Fenyö, David, Rodland, Karin D., Liu, Tao, Paulovich, Amanda G., Resnick, Adam C., Storm, Phillip B., Rood, Brian R., Wang, Pei, Morgan, Allison M., Waanders, Angela J., Buccoliero, Anna Maria, Leonard, Carina A., Kline, Cassie N., Li, Chunde, Kram, David E., Hanson, Derek, Appert, Elizabeth, Kawaler, Emily A., Raabe, Eric H., Jackson, Eric M., Greenfield, Jeffrey P., Pollack, Ian F., Cain, Jason E., Foster, Jessica B., Palma, July E., Ketchum, Karen A., Blumenberg, Lili, Cornwell, Macintosh, Sarmady, Mahdi, Domagalski, Marcin J., Cieślik, Marcin P., Li, Marilyn M., Wyczalkowski, Matthew A., Connors, Meghan, Gupta, Nalin, Edwards, Nathan J., Vaske, Olena M., Becher, Oren, Firestein, Ron, Mueller, Sabine, Winebrake, Samuel G., Dhanasekaran, Saravana Mohan, Cai, Shuang, Patton, Tatiana, Lorentzen, Travis D., Liu, Wenke, Bocik, William E.

“…We report a comprehensive proteogenomics analysis, including whole-genome sequencing, RNA sequencing, and proteomics and phosphoproteomics profiling, of 218…”
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OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma by Xu, Zhenhua, Murad, Najiba, Malawsky, Daniel, Tao, Ran, Rivero-Hinojosa, Samuel, Holdhof, Dörthe, Schüller, Ulrich, Zhang, Peng, Lazarski, Christopher, Rood, Brian R, Packer, Roger, Gershon, Timothy, Pei, Yanxin

“…Patients with MYC-amplified medulloblastoma (MB) have poor prognosis and frequently develop recurrence, thus new therapeutic approaches to prevent recurrence…”
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The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science by Lilly, Jena V., Rokita, Jo Lynne, Mason, Jennifer L., Patton, Tatiana, Stefankiewiz, Stephanie, Higgins, David, Trooskin, Gerri, Larouci, Carina A., Arya, Kamnaa, Appert, Elizabeth, Heath, Allison P., Zhu, Yuankun, Brown, Miguel A., Zhang, Bo, Farrow, Bailey K., Robins, Shannon, Morgan, Allison M., Nguyen, Thinh Q., Frenkel, Elizabeth, Lehmann, Kaitlin, Drake, Emily, Sullivan, Catherine, Plisiewicz, Alexa, Coleman, Noel, Patterson, Luke, Koptyra, Mateusz, Helili, Zeinab, Van Kuren, Nicholas, Young, Nathan, Kim, Meen Chul, Friedman, Christopher, Lubneuski, Alex, Blackden, Christopher, Williams, Marti, Baubet, Valerie, Tauhid, Lamiya, Galanaugh, Jamie, Boucher, Katie, Ijaz, Heba, Cole, Kristina A., Choudhari, Namrata, Santi, Mariarita, Moulder, Robert W., Waller, Jonathan, Rife, Whitney, Diskin, Sharon J., Mateos, Marion, Parsons, Donald W., Pollack, Ian F., Goldman, Stewart, Leary, Sarah, Caporalini, Chiara, Buccoliero, Anna Maria, Scagnet, Mirko, Haussler, David, Hanson, Derek, Firestein, Ron, Cain, Jason, Phillips, Joanna J., Gupta, Nalin, Mueller, Sabine, Grant, Gerald, Monje-Deisseroth, Michelle, Partap, Sonia, Greenfield, Jeffrey P., Hashizume, Rintaro, Smith, Amy, Zhu, Shida, Johnston, James M., Fangusaro, Jason R., Miller, Matthew, Wood, Matthew D., Gardner, Sharon, Carter, Claire L., Prolo, Laura M., Pisapia, Jared, Pehlivan, Katherine, Franson, Andrea, Niazi, Toba, Rubin, Josh, Abdelbaki, Mohamed, Ziegler, David S., Lindsay, Holly B., Stucklin, Ana Guerreiro, Gerber, Nicolas, Vaske, Olena M., Quinsey, Carolyn, Rood, Brian R., Nazarian, Javad, Raabe, Eric, Jackson, Eric M., Stapleton, Stacie, Lober, Robert M., Kram, David E., Koschmann, Carl, Storm, Phillip B., Lulla, Rishi R., Prados, Michael, Resnick, Adam C., Waanders, Angela J.

“…Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential…”
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A novel role of HLA class I in the pathology of medulloblastoma by Smith, Courtney, Santi, Mariarita, Rajan, Bhargavi, Rushing, Elisabeth J, Choi, Mi Rim, Rood, Brian R, Cornelison, Robert, MacDonald, Tobey J, Vukmanovic, Stanislav

“…MHC class I expression by cancer cells enables specific antigen recognition by the immune system and protection of the host. However, in some cancer types MHC…”
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Deciphering HIC1 control pathways to reveal new avenues in cancer therapeutics by Rood, Brian R, Leprince, Dominique

“…The tumor suppressor gene HIC1 (Hypermethylated in Cancer 1), which encodes a transcriptional repressor with multiple partners and multiple targets, is…”
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OLIG2 is a determinant for the relapse of MYC-amplified medulloblastoma by Xu, Zhenhua, Murad, Najiba, Malawsky, Daniel Shiloh, Tao, Ran, Rivero-Hinojosa, Samuel, Holdhof, Dörthe, Schuller, Ulrich, Zhang, Peng, Lazarski, Christopher A, Rood, Brian R, Packer, Roger, Gershon, Timothy R, Pei, Yanxin

“…Patients with MYC-amplified medulloblastoma (MB) have poor prognosis and frequently develop recurrence, thus new therapeutics to prevent recurrence are needed…”
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Long-term efficacy and toxicity of bevacizumab-based therapy in children with recurrent low-grade gliomas by Hwang, Eugene I., Jakacki, Regina I., Fisher, Michael J., Kilburn, Lindsay B., Horn, Marianna, Vezina, Gilbert, Rood, Brian R., Packer, Roger J.

“…Background Because definitive resection or radiotherapy for pediatric low‐grade gliomas (LGGs) may be associated with severe and permanent adverse effects,…”
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Germline microsatellite genotypes differentiate children with medulloblastoma by Rivero-Hinojosa, Samuel, Kinney, Nicholas, Garner, Harold R, Rood, Brian R

“…Abstract Background The germline genetic events underpinning medulloblastoma (MB) initiation, and therefore the ability to determine who is at risk, are still…”
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