Search Results - "Rong, Yiping"

Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis by Rong, Yiping, Distelhorst, Clark W

“…Bcl-2 family members are important regulators of cell survival and cell death. Researchers have focused mainly on mitochondria, where both proapoptotic and…”
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Targeting Hippo pathway by specific interruption of YAP‐TEAD interaction using cyclic YAP‐like peptides by Zhou, Zheng, Hu, Taishan, Xu, Zhiheng, Lin, Zhaohu, Zhang, Zhisen, Feng, Teng, Zhu, Liangcheng, Rong, Yiping, Shen, Hong, Luk, John M., Zhang, Xiongwen, Qin, Ning

“…ABSTRACT Hippo signaling pathway is emerging as a novel target for anticancer therapy because it plays key roles in organ size control and tumorigenesis. As…”
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Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction by Zhang, Zhisen, Lin, Zhaohu, Zhou, Zheng, Shen, Hong C, Yan, S. Frank, Mayweg, Alexander V, Xu, Zhiheng, Qin, Ning, Wong, Jason C, Zhang, Zhenshan, Rong, Yiping, Fry, David C, Hu, Taishan

“…The YAP–TEAD protein–protein interaction (PPI) mediates the oncogenic function of YAP, and inhibitors of this PPI have potential usage in treatment of…”
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Bisphenol A degradation by Fenton Advanced Oxidation Process and operation parameters optimization by Wang, Mingming, Su, Xiaoli, Yang, Songwen, Li, Ling, Li, Chaolin, Sun, Feiyun, Dong, Jiaju, Rong, Yiping

“…Bisphenol A (BPA) is a kind of environmental endocrine disrupting substance, which has been used as an organic chemical as unsaturated polyester resin. The…”
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Glucocorticoid-mediated Inhibition of Lck Modulates the Pattern of T Cell Receptor-induced Calcium Signals by Down-regulating Inositol 1,4,5-Trisphosphate Receptors by Harr, Michael W., Rong, Yiping, Bootman, Martin D., Roderick, H.Llewelyn, Distelhorst, Clark W.

“…Glucocorticoids are potent immunosuppressive agents that block upstream signaling events required for T cell receptor (TCR) activation. However, the mechanism…”
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1169 AZD5863: a specific, potent, affinity-optimized claudin 18.2 and CD3 binding T cell-engager that elicits low cytokine release and is capable of bystander killing by Gaspar, Miguel, Natoli, Marina, Castan, Laure, Rahmy, Sharif, Kelton, Cathryn, Mulgrew, Kathy, Korade, Martin, Huhn, Oisin, Gareth Rees, D, Sigurdardottir, Anna, Lloyd, Christopher, He, Yun, Rong, Yiping, Pollizzi, Kristen, Hammond, Scott, Cemerski, Saso, Dovedi, Simon, Cobbold, Mark, Ridgway, Benjamin, Broggi, Maria AS, Palmer, Douglas C, Ball, Kathryn, McFarlane, Mary, Vargas, Fred Arce, Ceaicovscaia, Natalia, Pouliot, Gayle, Szekeres, Philip, Fitzgerald, Jonathan, Kumar, Rakesh

“…BackgroundClaudin 18.2 (CLDN18.2), a tetraspanin family member essential for the formation of tight junctions,1 is highly expressed in gastric, pancreatic and…”
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Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid-treated lymphocytes by Swerdlow, Sarah, McColl, Karen, Rong, Yiping, Lam, Minh, Gupta, Anu, Distelhorst, Clark W.

“…Glucocorticosteroid hormones, including prednisone and dexamethasone (Dex), have been used to treat lymphoid malignancies for many years because they readily…”
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Tetrabromobisphenol A adsorption by active carbon: influential factors and kinetics by Su, Xiaoli, Wang, Mingming, Yang, Songwen, Sun, Feiyun, Dong, Jiaju, Rong, Yiping, Zhang, Bin, Hong, Desong

“…Frequency detection and environmental risk of Tetrabromobisphenol A （TBBPA）in aqueous system attracted many concerns. Nevertheless, mutual interactions between…”
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711 HBM1022, a novel anti-CCR8 antibody depletes tumor-infiltrating regulatory T cells via enhanced ADCC activity, mediates potent anti-tumor activity with Keytruda by Lu, Shuang, Hu, Shaoping, Gan, Xin, Wang, Yongqiang, Zhao, Chuchu, Ding, Yi, He, Jinqiu, Du, Qing, Lv, Xiaocheng, Qin, Beibei, He, Yun, Niu, Lei, Wu, Yuntao, Chen, Fei, Wang, Yuandong, Yang, Yunxing, Cao, Yang, Bao, Musheng, Noon, Jason, Yu, Wenhao, Liu, Juan, Zhao, Joe, Rong, Yiping

“…BackgroundCCR8-expressing CD4 and Foxp3 positive Treg (CCR8+ Treg) has been demonstrated to be a major driver for immunosuppression in solid tumors1…”
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Abstract 1603: Discover potent and functional human antibodies against a new B7-family member target for cancer immunotherapy by Wu, Xiaodong, Wang, Yongqiang, Lv, Xiaocheng, Chen, Fei, He, Yun, Zhao, Jiuqiao, Rong, Yiping

“…Abstract Immunotherapeutics targeting immune checkpoints such as PD1/PD-L1 and CTLA4 offer effective treatment alternatives to the traditional cancer…”
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An anti-CTLA-4 heavy chain-only antibody with enhanced T reg depletion shows excellent preclinical efficacy and safety profile by Gan, Xin, Shan, Qianqian, Li, He, Janssens, Rick, Shen, Yuqiang, He, Yun, Chen, Fei, van Haperen, Rien, Drabek, Dubravka, Li, Jin, Zhang, Yang, Zhao, Jiuqiao, Qin, Beibei, Jheng, Ming-Jin, Chen, Victor, Wang, Jingsong, Rong, Yiping, Grosveld, Frank

“…The value of anti-CTLA-4 antibodies in cancer therapy is well established. However, the broad application of currently available anti-CTLA-4 therapeutic…”
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An anti-CTLA-4 heavy chain–only antibody with enhanced Treg depletion shows excellent preclinical efficacy and safety profile by Gan, Xin, Shan, Qianqian, Li, He, Janssens, Rick, Shen, Yuqiang, He, Yun, Chen, Fei, van Haperen, Rien, Drabek, Dubravka, Li, Jin, Zhang, Yang, Zhao, Jiuqiao, Qin, Beibei, Jheng, Ming-Jin, Chen, Victor, Wang, Jingsong, Rong, Yiping, Grosveld, Frank

“…The value of anti-CTLA-4 antibodies in cancer therapy is well established. However, the broad application of currently available anti-CTLA-4 therapeutic…”
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Abstract 6056: A next-gen anti-CD73 Antibody with potential to show better efficacy and safety profile than existing approach by Gan, Xin, Shi, Lei, Shan, Qianqian, Chen, Fei, He, Yun, Rong, Yiping, Du, Qiumei

“…Abstract CD73, an ecto-5'-nucleotidase, plays a major role in de-phosphorylation of the extracellular adenosine monophosphate (AMP) to adenosine, which in turn…”
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Abstract 4098: A heavy chain only antibody against CTLA4 with outstanding preclinical efficacy and safety profile by Liu, George, Gan, Xin, He, Yun, Zhao, Jiuqiao, Duan, Huayan, Rong, Yiping

“…Abstract Anti-CTLA-4 antibodies are one of the only three types of immune checkpoint inhibitors (together with anti-PD-1 and anti-PD-L1 antibodies) with proven…”
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Benefit allocation of electricity–gas–heat–hydrogen integrated energy system based on Shapley value by Liu, Yujiao, Li, Yan, Rong, Yiping, Li, Guoliang, Wang, Ruiqi, Zhou, Haini

“…Abstract The integrated energy system is an important development direction for achieving energy transformation in the context of the low-carbon development…”
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Identification of a Novel Aminotetralin Class of HDAC6 and HDAC8 Selective Inhibitors by Tang, Guozhi, Wong, Jason C, Zhang, Weixing, Wang, Zhanguo, Zhang, Nan, Peng, Zhenghong, Zhang, Zhenshan, Rong, Yiping, Li, Shijie, Zhang, Meifang, Yu, Lingjie, Feng, Teng, Zhang, Xiongwen, Wu, Xihan, Wu, Jim Z, Chen, Li

“…Herein we report the identification of a novel class of HDAC6 and HDAC8 selective inhibitors through a unique chemistry and phenotypic screening strategy…”
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Design and Synthesis of Orally Bioavailable Aminopyrrolidinone Histone Deacetylase 6 Inhibitors by Lin, Xianfeng, Chen, Wenming, Qiu, Zongxing, Guo, Lei, Zhu, Wei, Li, Wentao, Wang, Zhanguo, Zhang, Weixing, Zhang, Zhenshan, Rong, Yiping, Zhang, Meifang, Yu, Lingjie, Zhong, Sheng, Zhao, Rong, Wu, Xihan, Wong, Jason C, Tang, Guozhi

“…Histone deacetylase 6 (HDAC6) removes the acetyl group from lysine residues in a number of non-histone substrates and plays important roles in microtubule…”
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1075 HBM1020 is a fully human novel anti-B7H7 antibody with excellent preclinical efficacy and safety profile by Wu, Xiaodong, Wang, Yongqiang, Liu, Jonna, Lv, Xiaocheng, Chen, Fei, Wang, Izzie, Zhao, Jiuqiao, Rong, Yiping

“…BackgroundImmunotherapeutic targeting immune checkpoints such as programmed death-1 receptor (PD-1)/PD1 ligand (PD-L1) and cytotoxic T-lymphocyte antigen-4…”
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1057 HBM7008, a first-in-class bispecific antibody targeting both B7-H4 and 4–1BB, exhibits robust anti-tumor immunity and low toxicity through B7-H4-directed 4–1BB activation by Huang, Bing, Du, Fangfang, Lv, Xiaocheng, Zhao, Jianxun, Chen, Fei, Lu, Zailian, Zhang, Yang, Chen, Victor, Gan, Xin, Zhao, Jiuqiao, He, Yun, Wu, Xiaodong, Rong, Yiping

“…Background4-1BB is an immune costimulatory receptor. Anti-4-1BB agonistic monoclonal antibodies have high potential of therapeutic efficacy in cancers…”
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Abstract 5559: Development of a novel PD-L1xCD40 bispecific antibody with excellent efficacy and safety profile for cancer therapy by luo, Haishan, Meng, Zihong, Rong, Jimmy, Wang, Yuandong, Yang, Yunxing, Chen, Fei, Wang, Youhong, Chen, Victor, Deng, Gang, He, Yebo, Gan, Xin, Rong, Yiping

“…Abstract CD40 agonistic antibody is emerging as a front-line immunotherapy for patients with cancer. However, despite its remarkable curative effects, serious…”
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