Search Results - "Rondon, G"

Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability by Mischo, Hannah E., Gómez-González, Belén, Grzechnik, Pawel, Rondón, Ana G., Wei, Wu, Steinmetz, Lars, Aguilera, Andrés, Proudfoot, Nick J.

“…Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated as well as some polyadenylated RNA…”
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The interface between transcription and mRNP export: From THO to THSC/TREX-2 by Rondón, Ana G., Jimeno, Sonia, Aguilera, Andrés

“…Eukaryotic gene expression is a multilayer process covering transcription to post-translational protein modifications. As the nascent pre-mRNA emerges from the…”
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Long-term outcomes of Sleeping Beauty–generated CD19-specific CAR T-cell therapy for relapsed-refractory B-cell lymphomas by Srour, S.A., Singh, H., McCarty, J., de Groot, E., Huls, H., Rondon, G., Qazilbash, M., Ciurea, S., Bardelli, G., Buck, J., Alousi, A., Nieto, Y., Rezvani, K., Marin, D., Popat, U., Hosing, C., Shpall, E.J., Wierda, W.G., Kantarjian, H., Champlin, R.E., Cooper, L.J., Kebriaei, P.

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The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability by Jimeno, S., Rondón, A. G., Luna, R., Aguilera, A.

“…The THO complex is a multimeric factor containing four polypeptides, Tho2, Hpr1, Mft1 and Thp2. Mutations in any of the genes encoding THO confer impairment of…”
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A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors by Tous, Cristina, Rondón, Ana G, García-Rubio, María, González-Aguilera, Cristina, Luna, Rosa, Aguilera, Andrés

“…To clarify the role of a number of mRNA processing factors in transcription elongation, we developed an in vivo assay for direct analysis of elongation on…”
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Fludarabine with pharmacokinetically guided IV busulfan is superior to fixed-dose delivery in pretransplant conditioning of AML/MDS patients by Andersson, B S, Thall, P F, Valdez, B C, Milton, D R, Al-Atrash, G, Chen, J, Gulbis, A, Chu, D, Martinez, C, Parmar, S, Popat, U, Nieto, Y, Kebriaei, P, Alousi, A, de Lima, M, Rondon, G, Meng, Q H, Myers, A, Kawedia, J, Worth, L L, Fernandez-Vina, M, Madden, T, Shpall, E J, Jones, R B, Champlin, R E

“…We hypothesized that IV busulfan (Bu) dosing could be safely intensified through pharmacokinetic (PK-) dose guidance to minimize the inter-patient variability…”
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Low-, medium- and high-dose steroids with or without aminocaproic acid in adult hematopoietic SCT patients with diffuse alveolar hemorrhage by Rathi, N K, Tanner, A R, Dinh, A, Dong, W, Feng, L, Ensor, J, Wallace, S K, Haque, S A, Rondon, G, Price, K J, Popat, U, Nates, J L

“…Diffuse alveolar hemorrhage (DAH) is a poorly understood complication of transplantation carrying a high mortality. Patients commonly deteriorate and require…”
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Pretransplant chest computed tomography screening in asymptomatic patients with leukemia and myelodysplastic syndrome by El Boghdadly, Z, Oran, B, Jiang, Y, Rondon, G, Champlin, R, Kontoyiannis, D P

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Symptomatic BK Virus Infection Is Associated With Kidney Function Decline and Poor Overall Survival in Allogeneic Hematopoietic Stem Cell Recipients by Abudayyeh, A., Hamdi, A., Lin, H., Abdelrahim, M., Rondon, G., Andersson, B. S., Afrough, A., Martinez, C. S., Tarrand, J. J., Kontoyiannis, D. P., Marin, D., Gaber, A. O., Salahudeen, A., Oran, B., Chemaly, R. F., Olson, A., Jones, R., Popat, U., Champlin, R. E., Shpall, E. J., Winkelmayer, W. C., Rezvani, K.

“…Nephropathy due to BK virus (BKV) infection is an evolving challenge in patients undergoing hematopoietic stem cell transplantation (HSCT). We hypothesized…”
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Prognostic value of response after upfront therapy for acute GVHD by Saliba, R M, Couriel, D R, Giralt, S, Rondon, G, Okoroji, G-J, Rashid, A, Champlin, R E, Alousi, A M

“…One challenge in designing clinical trials for treatment of acute GVHD (aGVHD) is the lack of an established standardized end point to measure the success of…”
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Comparison of outcomes at two institutions of patients with ALL receiving ex vivo T-cell-depleted or unmodified allografts by Hobbs, G S, Hamdi, A, Hilden, P D, Goldberg, J D, Poon, M L, Ledesma, C, Devlin, S M, Rondon, G, Papadopoulos, E B, Jakubowski, A A, O'Reilly, R J, Champlin, R E, Giralt, S, Perales, M-A, Kebriaei, P

“…We compared outcomes of adult patients receiving T-cell-depleted (TCD) hematopoietic SCT (HCT) without additional GVHD prophylaxis at Memorial Sloan Kettering…”
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Proton Versus Photon Craniospinal Irradiation for Hematologic Malignancies Involving the CNS: Effectiveness and Toxicity in the Setting of Stem Cell Transplant by Smith, G.L, Rahman, A.R, Dong, W, Kebriaei, P, Rondon, G, Pinnix, C.C, Milgrom, S.A, Allen, P.K, Dabaja, B

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Leukemia cell mobilization with G-CSF plus plerixafor during busulfan–fludarabine conditioning for allogeneic stem cell transplantation by Konopleva, M, Benton, C B, Thall, P F, Zeng, Z, Shpall, E, Ciurea, S, Kebriaei, P, Alousi, A, Popat, U, Anderlini, P, Nieto, Y, Parmar, S, Qiao, W, Chen, J, Rondon, G, McMullin, B, Wang, R-Y, Lu, H, Schober, W, Woodworth, G, Gulbis, A, Cool, R, Andreeff, M, Champlin, R

“…We hypothesized that during conditioning chemotherapy for allogeneic stem cell transplant (allo-SCT), the disruption of stromal–leukemia interactions using…”
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HLA-mismatched bone marrow transplantation in severe aplastic anemia by Bachegowda, L S, Shah, M V, Veltri, L W, Tanase, A, Popat, U, Anderlini, P, Chen, J, Rondon, G, Champlin, R E, Ciurea, S O

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Molecular evidence for a positive role of Spt4 in transcription elongation by Rondón, Ana G., García-Rubio, María, González-Barrera, Sergio, Aguilera, Andrés

“…We have previously shown that yeast mutants of the THO complex have a defect in gene expression, observed as an impairment of lacZ transcription. Here we…”
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R loops are linked to histone H3 S10 phosphorylation and chromatin condensation by Castellano-Pozo, Maikel, Santos-Pereira, José M, Rondón, Ana G, Barroso, Sonia, Andújar, Eloisa, Pérez-Alegre, Mónica, García-Muse, Tatiana, Aguilera, Andrés

“…R loops are transcription byproducts that constitute a threat to genome integrity. Here we show that R loops are tightly linked to histone H3 S10…”
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Donor type, in addition to transplantation in chronic phase and myeloablative conditioning, influence transplant survival for patients with advanced chronic myeloid leukemia in the era of tyrosine kinase inhibitors by Kongtim, P, Adekola, K, Milton, D R, Ramlal, R, Jimenez, A, Chen, J, Rondon, G, Ahmed, S, Kebriaei, P, Betul, O, Hosing, C M, Popat, U, Khouri, I, Jabbour, E, Cortes, J E, Kantarjian, H M, Champlin, R E, Ciurea, S O

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Molecular Evidence That the Eukaryotic THO/TREX Complex Is Required for Efficient Transcription Elongation by Rondón, Ana G., Jimeno, Sonia, García-Rubio, María, Aguilera, Andrés

“…THO/TREX is a conserved eukaryotic complex formed by the core THO complex plus proteins involved in mRNA metabolism and export such as Sub2 and Yra1. Mutations…”
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Outcomes of second allogeneic hematopoietic stem cell transplantation for patients with acute lymphoblastic leukemia by Poon, L M, Bassett Jr, R, Rondon, G, Hamdi, A, Qazilbash, M, Hosing, C, Jones, R B, Shpall, E J, Popat, U R, Nieto, Y, Worth, L L, Cooper, L, De Lima, M, Champlin, R E, Kebriaei, P

“…For patients with ALL who relapse following allo-SCT, only a second SCT provides a realistic chance for long-term disease remission. We retrospectively…”
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Salvage Radiation Therapy Prior to Stem Cell Transplantation for Chemorefractory B-Cell Lymphoma by Pinnix, C.C, Dabaja, B, Milgrom, S.A, Smith, G.L, Reed, V.K, Arzu, I.Y, Westin, J.R, Rondon, G, Hosing, C, Nieto, Y, Ahmed, S

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