Search Results - "Ronchi, Juliana A"
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A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities
Published in Free radical biology & medicine (01-10-2013)“…NADPH is the reducing agent for mitochondrial H2O2 detoxification systems. Nicotinamide nucleotide transhydrogenase (NNT), an integral protein located in the…”
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Redox imbalance due to the loss of mitochondrial NAD(P)-transhydrogenase markedly aggravates high fat diet-induced fatty liver disease in mice
Published in Free radical biology & medicine (01-12-2017)“…The mechanisms by which a high fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) appear to involve liver mitochondrial dysfunctions and redox…”
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Dichloroacetate reactivates pyruvate-supported peroxide removal by liver mitochondria and prevents NAFLD aggravation in NAD(P)+ transhydrogenase-null mice consuming a high-fat diet
Published in European journal of pharmacology (15-02-2022)“…The mechanisms by which a high-fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) appear to involve liver mitochondrial dysfunction and redox…”
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Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high‐fat diet
Published in Journal of neurochemistry (01-12-2018)“…Among mitochondrial NADP‐reducing enzymes, nicotinamide nucleotide transhydrogenase (NNT) establishes an elevated matrix NADPH/NADP+ by catalyzing the…”
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The C242T polymorphism of the p22-phox gene (CYBA) is associated with higher left ventricular mass in Brazilian hypertensive patients
Published in BMC medical genetics (31-08-2011)“…Reactive oxygen species have been implicated in the physiopathogenesis of hypertensive end-organ damage. This study investigated the impact of the C242T…”
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NADPH supply and the contribution of NAD(P)+ transhydrogenase (NNT) to H2O2 balance in skeletal muscle mitochondria
Published in Archives of biochemistry and biophysics (15-08-2021)“…H2O2 is endogenously generated and its removal in the matrix of skeletal muscle mitochondria (SMM) is dependent on NADPH likely provided by NAD(P)+…”
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Reactive oxygen species and permeability transition pore in rat liver and kidney mitoplasts
Published in Journal of bioenergetics and biomembranes (01-12-2011)“…Mitochondrial permeability transition is typically characterized by Ca 2+ and oxidative stress-induced opening of a nonselective proteinaceous membrane pore…”
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Increased Susceptibility of Gracilinanus microtarsus Liver Mitochondria to Ca²⁺-Induced Permeability Transition Is Associated with a More Oxidized State of NAD(P)
Published in Oxidative medicine and cellular longevity (2015)“…In addition to be the cell's powerhouse, mitochondria also contain a cell death machinery that includes highly regulated processes such as the membrane…”
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NADPH supply and the contribution of NAD(P) + transhydrogenase (NNT) to H 2 O 2 balance in skeletal muscle mitochondria
Published in Archives of biochemistry and biophysics (15-08-2021)“…H O is endogenously generated and its removal in the matrix of skeletal muscle mitochondria (SMM) is dependent on NADPH likely provided by NAD(P)…”
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Increased Susceptibility of Gracilinanus microtarsus Liver Mitochondria to Ca+2-Induced Permeability Transition Is Associated with a More Oxidized State of NAD(P)
Published in Oxidative medicine and cellular longevity (2015)“…In addition to be the cell’s powerhouse, mitochondria also contain a cell death machinery that includes highly regulated processes such as the membrane…”
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The C242T polymorphism of the p22-phox gene
Published in BMC medical genetics (31-08-2011)“…Reactive oxygen species have been implicated in the physiopathogenesis of hypertensive end-organ damage. This study investigated the impact of the C242T…”
Get full text
Journal Article