Search Results - "Ronald, John"
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Brightening up Biology: Advances in Luciferase Systems for in Vivo Imaging
Published in ACS chemical biology (17-12-2021)“…Bioluminescence imaging (BLI) using luciferase reporters is an indispensable method for the noninvasive visualization of cell populations and biochemical…”
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A novel approach for assessment of prostate cancer aggressiveness using survivin-driven tumour-activatable minicircles
Published in Gene therapy (01-05-2019)“…Early and accurate detection of cancer is essential to optimising patient outcomes. Of particular importance to prostate cancer is the ability to determine the…”
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3
Molecular imaging of cellular immunotherapies in experimental and therapeutic settings
Published in Cancer Immunology, Immunotherapy (01-06-2022)“…Cell-based cancer immunotherapies are becoming a routine part of the armamentarium against cancer. While remarkable successes have been seen, including durable…”
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4
Renal Lymphatics: Anatomy, Physiology, and Clinical Implications
Published in Frontiers in physiology (14-03-2019)“…Renal lymphatics are abundant in the cortex of the normal kidney but have been largely neglected in discussions around renal diseases. They originate in the…”
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Development of a Suite of Gadolinium-Free OATP1-Targeted Paramagnetic Probes for Liver MRI
Published in Journal of medicinal chemistry (25-05-2023)“…Five amphiphilic, anionic Mn(II) complexes were synthesized as contrast agents targeted to organic anion transporting polypeptide transporters (OATP) for…”
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International Health Regulations, Ebola, and Emerging Infectious Diseases in Latin America and the Caribbean
Published in American journal of public health (1971) (01-12-2018)“…The World Health Organization’s determination of the Ebola virus disease outbreak as a public health event of international concern prompted nonaffected…”
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7
Translational models of prostate cancer bone metastasis
Published in Nature reviews. Urology (01-07-2018)“…Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to accurately recapitulate the spread of prostate cancer to bone —…”
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Gadolinium-free Magnetic Resonance Imaging of the Liver via an Oatp1-Targeted Manganese(III) Porphyrin
Published in Journal of medicinal chemistry (28-07-2022)“…Controversy surrounding gadolinium-based contrast agents (GBCAs) has rendered their continued utility highly contentious, but the liver-specific GBCA Gd(III)…”
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Visualizing tumour self-homing with magnetic particle imaging
Published in Nanoscale (28-03-2021)“…Due to their innate tumour homing capabilities, in recent years, circulating tumour cells (CTCs) have been engineered to express therapeutic genes for targeted…”
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Visualizing cell-cell communication using synthetic notch activated MRI
Published in Proceedings of the National Academy of Sciences - PNAS (14-03-2023)“…Cell-cell communication plays a fundamental role in multicellular organisms. Cell-based cancer immunotherapies rely on the ability of innate or engineered…”
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A Genetically Encoded Magnetic Resonance Imaging Reporter Enables Sensitive Detection and Tracking of Spontaneous Metastases in Deep Tissues
Published in Cancer research (Chicago, Ill.) (02-03-2023)“…Metastasis is the leading cause of cancer-related death. However, it remains a poorly understood aspect of cancer biology, and most preclinical cancer studies…”
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Microvesicle-Mediated Delivery of Minicircle DNA Results in Effective Gene-Directed Enzyme Prodrug Cancer Therapy
Published in Molecular cancer therapeutics (01-12-2019)“…An emerging approach for cancer treatment employs the use of extracellular vesicles, specifically exosomes and microvesicles, as delivery vehicles. We…”
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13
International Health Regulations, Ebola, and Emerging Infectious Diseases in Latin America and the Caribbean
Published in American journal of public health (1971) (01-02-2016)“…The World Health Organization's determination of the Ebola virus disease outbreak as a public health event of international concern prompted nonaffected…”
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14
A synthetic notch (synNotch) system linking intratumoral immune-cancer cell communication to a synthetic blood biomarker assay
Published in Frontiers in pharmacology (2023)“…Cellular immunotherapy has greatly improved cancer treatment in recent years. For instance, chimeric antigen receptor (CAR) T cell therapy has been proven…”
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Invadopodia are chemosensing protrusions that guide cancer cell extravasation to promote brain tropism in metastasis
Published in Oncogene (01-05-2019)“…Invadopodia are cell protrusions that mediate cancer cell extravasation but the microenvironmental cues and signaling factors that induce invadopodia formation…”
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A human rights-based framework to assess gender equality in health systems: the example of Zika virus in the Americas
Published in Global health action (2019)“…Background: The right to health was enshrined in the constitution of the World Health Organization (WHO) in 1946 and in the Universal Declaration of Human…”
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Controlled Self-Assembling of Gadolinium Nanoparticles as Smart Molecular Magnetic Resonance Imaging Contrast Agents
Published in Angewandte Chemie International Edition (04-07-2011)“…Gd smart: MRI contrast agents are presented that are based on a biocompatible condensation reaction. Upon reduction, a gadolinium‐containing cell‐permeable…”
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A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant
Published in Cancer research (Chicago, Ill.) (01-06-2017)“…A major barrier to successful use of allogeneic hematopoietic cell transplantation is acute graft-versus-host disease (aGVHD), a devastating condition that…”
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A Protocol for Simultaneous In Vivo Imaging of Cardiac and Neuroinflammation in Dystrophin-Deficient MDX Mice Using [ 18 F]FEPPA PET
Published in International journal of molecular sciences (19-04-2023)“…Duchenne muscular dystrophy (DMD) is a neuromuscular disorder caused by dystrophin loss-notably within muscles and the central neurons system. DMD presents as…”
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A Human-derived Dual MRI/PET Reporter Gene System with High Translational Potential for Cell Tracking
Published in Molecular imaging and biology (01-04-2022)“…Purpose Reporter gene imaging has been extensively used to longitudinally report on whole-body distribution and viability of transplanted engineered cells…”
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