Norepinephrine transporter gene polymorphism is not associated with susceptibility to alcohol dependence

Abnormalities in monoamine neurotransmission have been implicated in the pathogenesis of alcoholism, mood disorders and schizophrenia. Murine norepinephrine transporter gene (NET) has been mapped to a region on chromosome 8 where a quantitative trait locus for ethanol sensitivity. Therefore we teste...

Full description

Saved in:

Bibliographic Details
Published in:	Psychiatry research Vol. 111; no. 2; pp. 229 - 233
Main Authors:	Samochowiec, Jerzy, Kucharska–Mazur, Jolanta, Kaminski, Ryszard, Smolka, Michael, Rommelschpacher, Hans, Wernicke, Catrin, Tymicz, Agnieszka, Schmidt, Lutz Gerhardt
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 30-08-2002 Elsevier
Subjects:	Addictive behaviors Adult Adult and adolescent clinical studies Alcohol dependence Alcohol Withdrawal Delirium - genetics Alcoholism Alcoholism - genetics Alleles Biological and medical sciences DNA Mutational Analysis Exons Female Gene Frequency - genetics Genetic Predisposition to Disease - genetics Genetics Genotype Humans Male Medical sciences Middle Aged Molecular Sequence Data Norepinephrine Plasma Membrane Transport Proteins Norepinephrine transporter gene association Polymorphism, Genetic - genetics Polymorphism, Restriction Fragment Length Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry RNA, Messenger - genetics Symporters - genetics Norepinephrine transporter gene association Alcohol dependence Genetics Human Genetic marker Alcoholism Genetic variant Prediction Vulnerability Chromosome C8 Genetic determinism Alcoholic beverage Symptomatology Addiction Dependence Noradrenergic transmission Severe Withdrawal syndrome Polymorphism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Abnormalities in monoamine neurotransmission have been implicated in the pathogenesis of alcoholism, mood disorders and schizophrenia. Murine norepinephrine transporter gene (NET) has been mapped to a region on chromosome 8 where a quantitative trait locus for ethanol sensitivity. Therefore we tested whether norepinephrine transporter (NET) gene variants confer susceptibility to either alcohol dependence or severe alcohol withdrawal symptoms. There is a highly polymorphic silent G1287A mutation in the NET gene. In our study 157 alcoholics and 185 healthy unrelated matched control subjects were analyzed for a silent G1287A mutation. No significant differences in allele and genotype distribution between control subjects f(A)=0.33 and alcoholics f(A)=0.29 were found. No significant results were found in more homogenous subgroups, i.e. alcoholics with severe alcohol withdrawal (seizures, delirium), early onset age<26 nor dependent patients with positive familial history of alcoholism. These results suggest that the NET gene polymorphism in exon 9 accession number: mRNA: NM_001043, genomic contig.: NT_019610, is unlikely to be involved in the susceptibility to alcoholism and severe alcohol withdrawal.
ISSN:	0165-1781 1872-7123
DOI:	10.1016/S0165-1781(02)00145-2