Search Results - "Rommel, Philipp C."

Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma by Robbiani, Davide F., Deroubaix, Stephanie, Feldhahn, Niklas, Oliveira, Thiago Y., Callen, Elsa, Wang, Qiao, Jankovic, Mila, Silva, Israel T., Rommel, Philipp C., Bosque, David, Eisenreich, Tom, Nussenzweig, André, Nussenzweig, Michel C.

“…Chronic infection with Plasmodium falciparum was epidemiologically associated with endemic Burkitt’s lymphoma, a mature B cell cancer characterized…”
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RPA Accumulation during Class Switch Recombination Represents 5′–3′ DNA-End Resection during the S–G2/M Phase of the Cell Cycle by Yamane, Arito, Robbiani, Davide F., Resch, Wolfgang, Bothmer, Anne, Nakahashi, Hirotaka, Oliveira, Thiago, Rommel, Philipp C., Brown, Eric J., Nussenzweig, Andre, Nussenzweig, Michel C., Casellas, Rafael

“…Activation-induced cytidine deaminase (AID) promotes chromosomal translocations by inducing DNA double-strand breaks (DSBs) at immunoglobulin (Ig) genes and…”
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Blm10 Protein Promotes Proteasomal Substrate Turnover by an Active Gating Mechanism by Dange, Thomas, Smith, David, Noy, Tahel, Rommel, Philipp C., Jurzitza, Lukas, Cordero, Radames J.B., Legendre, Anne, Finley, Daniel, Goldberg, Alfred L., Schmidt, Marion

“…For optimal proteolytic function, the central core of the proteasome (core particle (CP) or 20S) has to associate with activators. We investigated the impact…”
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Fate mapping for activation-induced cytidine deaminase (AID) marks non-lymphoid cells during mouse development by Rommel, Philipp C, Bosque, David, Gitlin, Alexander D, Croft, Gist F, Heintz, Nathaniel, Casellas, Rafael, Nussenzweig, Michel C, Kriaucionis, Skirmantas, Robbiani, Davide F

“…The Aicda gene encodes Activation-Induced cytidine Deaminase (AID), an enzyme essential for remodeling antibody genes in mature B lymphocytes. AID is also…”
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Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching by Bothmer, Anne, Rommel, Philipp C, Gazumyan, Anna, Polato, Federica, Reczek, Colleen R, Muellenbeck, Matthias F, Schaetzlein, Sonja, Edelmann, Winfried, Chen, Phang-Lang, Brosh, Jr, Robert M, Casellas, Rafael, Ludwig, Thomas, Baer, Richard, Nussenzweig, André, Nussenzweig, Michel C, Robbiani, Davide F

“…DNA double-strand breaks (DSBs) are byproducts of normal cellular metabolism and obligate intermediates in antigen receptor diversification reactions. These…”
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An NK-like CAR T cell transition in CAR T cell dysfunction by Good, Charly R., Aznar, M. Angela, Kuramitsu, Shunichiro, Samareh, Parisa, Agarwal, Sangya, Donahue, Greg, Ishiyama, Kenichi, Wellhausen, Nils, Rennels, Austin K., Ma, Yujie, Tian, Lifeng, Guedan, Sonia, Alexander, Katherine A., Zhang, Zhen, Rommel, Philipp C., Singh, Nathan, Glastad, Karl M., Richardson, Max W., Watanabe, Keisuke, Tanyi, Janos L., O’Hara, Mark H., Ruella, Marco, Lacey, Simon F., Moon, Edmund K., Schuster, Stephen J., Albelda, Steven M., Lanier, Lewis L., Young, Regina M., Berger, Shelley L., June, Carl H.

“…Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable success in hematological malignancies but remains ineffective in solid tumors, due in…”
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Better living through chemistry: CRISPR/Cas engineered T cells for cancer immunotherapy by Wellhausen, Nils, Agarwal, Sangya, Rommel, Philipp C, Gill, Saar I, June, Carl H

“…•Gene editing using CRIPSR/Cas has the potential to increase anti-tumor efficacy and persistence of adoptively transferred cells.•Allogeneic T cells can be…”
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Potentiating adoptive cell therapy using synthetic IL-9 receptors by Kalbasi, Anusha, Siurala, Mikko, Su, Leon L., Tariveranmoshabad, Mito, Picton, Lora K., Ravikumar, Pranali, Li, Peng, Lin, Jian-Xin, Escuin-Ordinas, Helena, Da, Tong, Kremer, Sarah V., Sun, Amy L., Castelli, Sofia, Agarwal, Sangya, Scholler, John, Song, Decheng, Rommel, Philipp C., Radaelli, Enrico, Young, Regina M., Leonard, Warren J., Ribas, Antoni, June, Carl H., Garcia, K. Christopher

“…Synthetic receptor signalling has the potential to endow adoptively transferred T cells with new functions that overcome major barriers in the treatment of…”
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Enhancing chimeric antigen receptor T cell therapy by modulating the p53 signaling network with Δ133p53α by Roselle, Christopher, Horikawa, Izumi, Chen, Linhui, Kelly, Andre R, Gonzales, Donna, Da, Tong, Wellhausen, Nils, Rommel, Philipp C, Baker, Daniel, Suhoski, Megan, Scholler, John, O'Connor, Roddy S, Young, Regina M, Harris, Curtis C, June, Carl H

“…Chimeric antigen receptor (CAR) T cell dysfunction is a major barrier to achieving lasting remission in hematologic cancers, especially in chronic lymphocytic…”
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RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks by Rommel, Philipp C, Oliveira, Thiago Y, Nussenzweig, Michel C, Robbiani, Davide F

“…The RAG recombinase (RAG1/2) plays an essential role in adaptive immunity by mediating V(D)J recombination in developing lymphocytes. In contrast, aberrant…”
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Publisher Correction: Potentiating adoptive cell therapy using synthetic IL-9 receptors by Kalbasi, Anusha, Siurala, Mikko, Su, Leon L., Tariveranmoshabad, Mito, Picton, Lora K., Ravikumar, Pranali, Li, Peng, Lin, Jian-Xin, Escuin-Ordinas, Helena, Da, Tong, Kremer, Sarah V., Sun, Amy L., Castelli, Sofia, Agarwal, Sangya, Scholler, John, Song, Decheng, Rommel, Philipp C., Radaelli, Enrico, Young, Regina M., Leonard, Warren J., Ribas, Antoni, June, Carl H., Garcia, K. Christopher

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Correction: RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks by Rommel, Philipp C, Oliveira, Thiago Y, Nussenzweig, Michel C, Robbiani, Davide F

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Abstract 3602: Mechanisms of CAR T cell dysfunction and identification of transcription factors that drive the exhaustion phenotype by Aznar, M. Angela, Good, Charly R., Kuramitsu, Shunichiro, Samareh, Parisa, Agarwal, Sangya, Donahue, Greg, Ishiyama, Kenichi, Wellhausen, Nils, Rennels, Austin K., Ma, Yujie, Tian, Lifeng, Guedan, Sonia, Alexander, Katherine A., Zhang, Zhen, Rommel, Philipp C., Singh, Nathan, Glastad, Karl M., Richardson, Max W., Watanabe, Keisuke, Tanyi, Janos L., O’Hara, Mark H., Ruella, Marco, Lacey, Simon F., Moon, Edmund K., Schuster, Stephen J., Albelda, Steven M., Lanier, Lewis L., Young, Regina M., Berger, Shelley L., June, Carl H.

“…Abstract Chimeric antigen receptor (CAR) T cell immunotherapy is FDA approved for the treatment of a subset of B cell malignancies but has shown limited…”
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Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching by Bothmer, Anne, Rommel, Philipp C., Gazumyan, Anna, Polato, Federica, Reczek, Colleen R., Muellenbeck, Matthias F., Schaetzlein, Sonja, Edelmann, Winfried, Chen, Phang-Lang, Brosh, Robert M., Casellas, Rafael, Ludwig, Thomas, Baer, Richard, Nussenzweig, André, Nussenzweig, Michel C., Robbiani, Davide F.

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Fate Mapping for Activation-Induced Cytidine Deaminase (AID) Marks Non-Lymphoid Cells During Mouse Development. e69208 by Rommel, Philipp C, Bosque, David, Gitlin, Alexander D, Croft, Gist F, Heintz, Nathaniel, Casellas, Rafael, Nussenzweig, Michel C, Kriaucionis, Skirmantas, Robbiani, Davide F

“…The Aicda gene encodes Activation-Induced cytidine Deaminase (AID), an enzyme essential for remodeling antibody genes in mature B lymphocytes. AID is also…”
Get full text