Search Results - "Romines, Karen R"

Structure−Activity Relationship Studies of Novel Benzophenones Leading to the Discovery of a Potent, Next Generation HIV Nonnucleoside Reverse Transcriptase Inhibitor by Romines, Karen R, Freeman, George A, Schaller, Lee T, Cowan, Jill R, Gonzales, Steve S, Tidwell, Jeffrey H, Andrews, Clarence W, Stammers, David K, Hazen, Richard J, Ferris, Robert G, Short, Steven A, Chan, Joseph H, Boone, Lawrence R

“…Despite the progress of the past two decades, there is still considerable need for safe, efficacious drugs that target human immunodeficiency virus (HIV). This…”
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Antiviral Activity of GW678248, a Novel Benzophenone Nonnucleoside Reverse Transcriptase Inhibitor by FERRIS, Robert G, HAZEN, Richard J, SHORT, Steven A, WEAVER, Kurt L, SELLESETH, Dean W, MONIRI, Kelly R, BOONE, Lawrence R, ROBERTS, Grace B, CLAIR, Marty H. St, CHAN, Joseph H, ROMINES, Karen R, FREEMAN, George A, TIDWELL, Jeffrey H, SCHALLER, Lee T, COWAN, Jill R

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Anti-Human Immunodeficiency Virus Type 1 Activity of the Nonnucleoside Reverse Transcriptase Inhibitor GW678248 in Combination with Other Antiretrovirals against Clinical Isolate Viruses and In Vitro Selection for Resistance by HAZEN, Richard J, HARVEY, Robert J, CHAN, Joseph H, BOONE, Lawrence R, CLAIR, Marty H. St, FERRIS, Robert G, FREEMAN, George A, TIDWELL, Jeffrey H, SCHALLER, Lee T, COWAN, Jill R, SHORT, Steven A, ROMINES, Karen R

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Structural Basis for the Improved Drug Resistance Profile of New Generation Benzophenone Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors by Ren, Jingshan, Chamberlain, Philip P, Stamp, Anna, Short, Steven A, Weaver, Kurt L, Romines, Karen R, Hazen, Richard, Freeman, Andrew, Ferris, Robert G, Andrews, C. Webster, Boone, Lawrence, Chan, Joseph H, Stammers, David K

“…Owing to the emergence of resistant virus, next generation non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) with improved drug resistance profiles…”
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Substituted tetrahydrocarbazoles with potent activity against human papillomaviruses by Gudmundsson, Kristjan S., Sebahar, Paul R., Richardson, Leah D’Aurora, Catalano, John G., Boggs, Sharon D., Spaltenstein, Andrew, Sethna, Phiroze B., Brown, Kevin W., Harvey, Robert, Romines, Karen R.

“…Synthesis of a series of substituted 1-aminotetrahydrocarbazoles with potent activity against human papillomaviruses is described. Synthetic approaches…”
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Substituted tetrahydro-β-carbolines as potential agents for the treatment of human papillomavirus infection by Miller, John F., Turner, Elizabeth M., Sherrill, Ronald G., Gudmundsson, Kristjan, Spaltenstein, Andrew, Sethna, Phiroze, Brown, Kevin W., Harvey, Robert, Romines, Karen R., Golden, Pamela

“…The identification and optimization of a series of substituted tetrahydro-β-carbolines with potent activity against human papillomavirus is described…”
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GSK983: A novel compound with broad-spectrum antiviral activity by Harvey, Robert, Brown, Kevin, Zhang, Qin, Gartland, Margaret, Walton, Leslie, Talarico, Christine, Lawrence, Wendell, Selleseth, Dean, Coffield, Neil, Leary, Jeffry, Moniri, Kelly, Singer, Sara, Strum, Jay, Gudmundsson, Kristjan, Biron, Karen, Romines, Karen R., Sethna, Phiroze

“…GSK983, a novel tetrahydrocarbazole, inhibits the replication of a variety of unrelated viruses in vitro with EC 50 values of 5–20 nM. Both replication of the…”
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Tetrahydrocarbazole amides with potent activity against human papillomaviruses by Gudmundsson, Kristjan S., Boggs, Sharon D., Sebahar, Paul R., Richardson, Leah D’Aurora, Spaltenstein, Andrew, Golden, Pamela, Sethna, Phiroze B., Brown, Kevin W., Moniri, Kelly, Harvey, Robert, Romines, Karen R.

“…Synthesis and optimization of a series of tetrahydrocarbazole amides with potent activity against human papillomaviruses and desirable development properties…”
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A Facile Asymmetric Synthesis of 1,2,3-Substituted Indenes by Romines, Karen R, Lovasz, Kristine D, Mizsak, Stephen A, Morris, Jeanette K, Seest, Eric P, Han, Fusen, Tulinsky, John, Judge, Thomas M, Gammill, Ronald B

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Novel Benzophenones as Non-nucleoside Reverse Transcriptase Inhibitors of HIV-1 by Chan, Joseph H, Freeman, George A, Tidwell, Jeffrey H, Romines, Karen R, Schaller, Lee T, Cowan, Jill R, Gonzales, Steve S, Lowell, Gina S, Andrews, C. W, Reynolds, David J, St Clair, Marty, Hazen, Richard J, Ferris, Rob G, Creech, Katrina L, Roberts, Grace B, Short, Steven A, Weaver, Kurt, Koszalka, George W, Boone, Lawrence R

“…GW4511, GW4751, and GW3011 showed IC50 values ≤2 nM against wild type HIV-1 and <10 nM against 16 mutants. They were particularly potent against…”
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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors from a Cyclooctylpyranone Lead Structure by Romines, Karen R, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Lovasz, Kristine D, Morris, Jeanette K, Janakiraman, Musiri N, Lynn, Janet C, Horng, Miao-Miao

“…Recently, the novel cyclooctylpyranone HIV protease inhibitor 1 was identified in our labs, and an X-ray structure of this inhibitor complexed with HIV-2…”
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Cycloalkylpyranones and Cycloalkyldihydropyrones as HIV Protease Inhibitors:  Exploring the Impact of Ring Size on Structure−Activity Relationships by Romines, Karen R, Morris, Jeanette K, Howe, W. Jeffrey, Tomich, Paul K, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Anderson, David J, Strohbach, Joseph W, Turner, Steve R, Mizsak, Steve A

“…Previously, 3-substituted cycloalkylpyranones, such as 2d, have proven to be effective inhibitors of HIV protease. In an initial series of 3-(1-phenylpropyl)…”
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Substituted tetrahydro-b-carbolines as potential agents for the treatment of human papillomavirus infection by Miller, John F, Turner, Elizabeth M, Sherrill, Ronald G, Gudmundsson, Kristjan, Spaltenstein, Andrew, Sethna, Phiroze, Brown, Kevin W, Harvey, Robert, Romines, Karen R, Golden, Pamela

“…The identification and optimization of a series of substituted tetrahydro-b-carbolines with potent activity against human papillomavirus is described…”
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Structure-Based Design of Sulfonamide-Substituted Non-Peptidic HIV Protease Inhibitors by Skulnick, Harvey I, Johnson, Paul D, Howe, W. Jeffrey, Tomich, Paul K, Chong, Kong-Teck, Watenpaugh, Keith D, Janakiraman, Musiri N, Dolak, Lester A, McGrath, James P

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Use of Medium-Sized Cycloalkyl Rings To Enhance Secondary Binding: Discovery of a New Class of Human Immunodeficiency Virus (HIV) Protease Inhibitors by Romines, Karen R, Watenpaugh, Keith D, Tomich, Paul K, Howe, W. Jeffrey, Morris, Jeanette K, Lovasz, Kristine D, Mulichak, Anne M, Finzel, Barry C, Lynn, Janet C

“…A unique strategy for the enhancement of secondary binding of an inhibitor to an enzyme has been demonstrated in the design of new human immunodeficiency virus…”
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