Search Results - "Romine, Jeffrey L."

Identification of Hepatitis C Virus NS5A Inhibitors by LEMM, Julie A, O'BOYLE, Donald, ROMINE, Jeffrey L, MEANWELL, Nicholas A, MIN GAO, MENGPING LIU, NOWER, Peter T, COLONNO, Richard, DESHPANDE, Milind S, SNYDER, Lawrence B, MARTIN, Scott W, LAURENT, Denis R. St, SERRANO-WU, Michael H

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Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures by Lemm, Julie A, Leet, John E, O'Boyle, 2nd, Donald R, Romine, Jeffrey L, Huang, Xiaohua Stella, Schroeder, Daniel R, Alberts, Jeffrey, Cantone, Joseph L, Sun, Jin-Hua, Nower, Peter T, Martin, Scott W, Serrano-Wu, Michael H, Meanwell, Nicholas A, Snyder, Lawrence B, Gao, Min

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Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes by Romine, Jeffrey L, St. Laurent, Denis R, Leet, John E, Martin, Scott W, Serrano-Wu, Michael H, Yang, Fukang, Gao, Min, O’Boyle, Donald R, Lemm, Julie A, Sun, Jin-Hua, Nower, Peter T, Huang, Xiaohua (Stella), Deshpande, Milind S, Meanwell, Nicholas A, Snyder, Lawrence B

“…The iminothiazolidinone BMS-858 (2) was identified as a specific inhibitor of HCV replication in a genotype 1b replicon assay via a high-throughput screening…”
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Discovery and Development of Hepatitis C Virus NS5A Replication Complex Inhibitors by Belema, Makonen, Lopez, Omar D., Bender, John A., Romine, Jeffrey L., St. Laurent, Denis R., Langley, David R., Lemm, Julie A., O’Boyle, Donald R., Sun, Jin-Hua, Wang, Chunfu, Fridell, Robert A., Meanwell, Nicholas A.

“…Lead inhibitors that target the function of the hepatitis C virus (HCV) nonstructural 5A (NS5A) protein have been identified by phenotypic screening campaigns…”
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Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir by Belema, Makonen, Nguyen, Van N., Bachand, Carol, Deon, Dan H., Goodrich, Jason T., James, Clint A., Lavoie, Rico, Lopez, Omar D., Martel, Alain, Romine, Jeffrey L., Ruediger, Edward H., Snyder, Lawrence B., Laurent, Denis R. St, Yang, Fukang, Zhu, Juliang, Wong, Henry S., Langley, David R., Adams, Stephen P., Cantor, Glenn H., Chimalakonda, Anjaneya, Fura, Aberra, Johnson, Benjamin M., Knipe, Jay O., Parker, Dawn D., Santone, Kenneth S., Fridell, Robert A., Lemm, Julie A., O’Boyle, Donald R., Colonno, Richard J., Gao, Min, Meanwell, Nicholas A., Hamann, Lawrence G.

“…The biphenyl derivatives 2 and 3 are prototypes of a novel class of NS5A replication complex inhibitors that demonstrate high inhibitory potency toward a panel…”
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Characterizations of HCV NS5A replication complex inhibitors by O'Boyle II, Donald R, Sun, Jin-Hua, Nower, Peter T, Lemm, Julie A, Fridell, Robert A, Wang, Chunfu, Romine, Jeffrey L, Belema, Makonen, Nguyen, Van N, Laurent, Denis R. St, Serrano-Wu, Michael, Snyder, Lawrence B, Meanwell, Nicholas A, Langley, David R, Gao, Min

“…Abstract The hepatitis C virus NS5A protein is an established and clinically validated target for antiviral intervention by small molecules. Characterizations…”
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Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097 by Mathur, Arvind, Wang, Bei, Smith, Daniel, Li, Jianqing, Pawluczyk, Joseph, Sun, Jung-Hui, Wong, Michael Kwok, Krishnananthan, Subramaniam, Wu, Dauh-Rurng, Sun, Dawn, Li, Peng, Yip, Shiuhang, Chen, Bang-Chi, Baran, Phil S, Chen, Qi, Lopez, Omar D, Yong, Zhong, Bender, John A, Nguyen, Van N, Romine, Jeffrey L, Laurent, Denis R. St, Wang, Gan, Kadow, John F, Meanwell, Nicholas A, Belema, Makonen, Zhao, Rulin

“…An efficient large-scale synthesis of acid 1, a penultimate precursor to the HCV NS5A inhibitor BMS-986097, along with the final API step are described. Three…”
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Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons by Belema, Makonen, Nguyen, Van N., Romine, Jeffrey L., St. Laurent, Denis R., Lopez, Omar D., Goodrich, Jason T., Nower, Peter T., O’Boyle, Donald R., Lemm, Julie A., Fridell, Robert A., Gao, Min, Fang, Hua, Krause, Rudolph G., Wang, Ying-Kai, Oliver, A. Jayne, Good, Andrew C., Knipe, Jay O., Meanwell, Nicholas A., Snyder, Lawrence B.

“…A medicinal chemistry campaign that was conducted to address a potential genotoxic liability associated with an aniline-derived scaffold in a series of HCV…”
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HCV NS5A replication complex inhibitors. Part 2: Investigation of stilbene prolinamides by St. Laurent, Denis R., Belema, Makonen, Gao, Min, Goodrich, Jason, Kakarla, Ramesh, Knipe, Jay O., Lemm, Julie A., Liu, Mengping, Lopez, Omar D., Nguyen, Van N., Nower, Peter T., O’Boyle, Donald, Qiu, Yuping, Romine, Jeffrey L., Serrano-Wu, Michael H., Sun, Jin-Hua, Valera, Lourdes, Yang, Fukang, Yang, Xuejie, Meanwell, Nicholas A., Snyder, Lawrence B.

“…In a previous disclosure,1 we reported the dimerization of an iminothiazolidinone to form 1, a contributor to the observed inhibition of HCV genotype 1b…”
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3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR by Romine, Jeffrey L, Martin, Scott W, Meanwell, Nicholas A, Gribkoff, Valentin K, Boissard, Christopher G, Dworetzky, Steven I, Natale, Joanne, Moon, Sandra, Ortiz, Astrid, Yeleswaram, Swamy, Pajor, Lorraine, Gao, Qi, Starrett, Jr, John E

“…Compound 8a (BMS-191011), an opener of the cloned large-conductance, Ca2+-activated potassium (maxi-K) channel, demonstrated efficacy in in vivo stroke models,…”
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HCV NS5A Replication Complex Inhibitors. Part 4. Optimization for Genotype 1a Replicon Inhibitory Activity by St. Laurent, Denis R., Serrano-Wu, Michael H., Belema, Makonen, Ding, Min, Fang, Hua, Gao, Min, Goodrich, Jason T., Krause, Rudolph G., Lemm, Julie A., Liu, Mengping, Lopez, Omar D., Nguyen, Van N., Nower, Peter T., O’Boyle, Donald R., Pearce, Bradley C., Romine, Jeffrey L., Valera, Lourdes, Sun, Jin-Hua, Wang, Ying-Kai, Yang, Fukang, Yang, Xuejie, Meanwell, Nicholas A., Snyder, Lawrence B.

“…A series of symmetrical E-stilbene prolinamides that originated from the library-synthesized lead 3 was studied with respect to HCV genotype 1a (G-1a) and…”
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The Synthesis and evaluation of a novel class of ( E)-3-(1-cyclohexyl-1 H-pyrazol-3-yl)-2-methylacrylic acid Hepatitis C virus polymerase NS5B inhibitors by Martin, Scott W., Glunz, Peter, Beno, Brett R., Bergstrom, Carl, Romine, Jeffrey L., Scott Priestley, E., Newman, Makenzie, Gao, Min, Roberts, Susan, Rigat, Karen, Fridell, Robert, Qiu, Dike, Knobloh, Galina, Wang, Ying-Kai

“…Presented is the identification and evaluation of a novel series of ( E)-3-(1-cyclohexyl-1 H-pyrazol-3-yl)-2-methylacrylic acid derivatives identified from a…”
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Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: bioisosteric urea replacements by POINDEXTER, Graham S, BRUCE, Marc A, RUSSELL, John, ANTAL-ZIMANYI, Ildiko, BREITENBUCHER, J. Guy, HIGGINS, Mendi A, SIT, S.-Y, ROMINE, Jeffrey L, MARTIN, Scott W, WARD, Sally A, MCGOVERN, Rachel T, CLARKE, Wendy

“…Structure-activity studies around the urea linkage in BMS-193885 (4a) identified the cyanoguanidine moiety as an effective urea replacement in a series of…”
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3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011:  Opener of Large-Conductance Ca2+-Activated Potassium (Maxi-K) Channels, Identification, Solubility, and SAR by Romine, Jeffrey L, Martin, Scott W, Meanwell, Nicholas A, Gribkoff, Valentin K, Boissard, Christopher G, Dworetzky, Steven I, Natale, Joanne, Moon, Sandra, Ortiz, Astrid, Yeleswaram, Swamy, Pajor, Lorraine, Gao, Qi, Starrett, John E

“…Compound 8a (BMS-191011), an opener of the cloned large-conductance, Ca2+-activated potassium (maxi-K) channel, demonstrated efficacy in in vivo stroke models,…”
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4,5-diphenyltriazol-3-ones: openers of large-conductance Ca(2+)-activated potassium (maxi-K) channels by Romine, Jeffrey L, Martin, Scott W, Gribkoff, Valentin K, Boissard, Christopher G, Dworetzky, Steven I, Natale, Joanne, Li, Yi, Gao, Qi, Meanwell, Nicholas A, Starrett, Jr, John E

“…A series of diphenyl-substituted heterocycles were synthesized and evaluated by electrophysiological techniques as openers of the cloned mammalian…”
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Total synthesis of (+)-ikarugamycin. 1. Stereocontrolled construction of the decahydro-as-indacene subunit by Paquette, Leo A, Romine, Jeffrey L, Lin, Ho Shen, Wright, Jonathan

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4,5-Diphenyltriazol-3-ones:  Openers of Large-Conductance Ca2+-Activated Potassium (Maxi-K) Channels by Romine, Jeffrey L, Martin, Scott W, Gribkoff, Valentin K, Boissard, Christopher G, Dworetzky, Steven I, Natale, Joanne, Li, Yi, Gao, Qi, Meanwell, Nicholas A, Starrett, John E

“…A series of diphenyl-substituted heterocycles were synthesized and evaluated by electrophysiological techniques as openers of the cloned mammalian…”
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HCV NS5A Replication Complex Inhibitors. Part 4.1 Optimization for Genotype 1a Replicon Inhibitory Activity by St. Laurent, Denis R., Serrano-Wu, Michael H., Belema, Makonen, Ding, Min, Fang, Hua, Gao, Min, Goodrich, Jason T., Krause, Rudolph G., Lemm, Julie A., Liu, Mengping, Lopez, Omar D., Nguyen, Van N., Nower, Peter T., O’Boyle, Donald R., Pearce, Bradley C., Romine, Jeffrey L., Valera, Lourdes, Sun, Jin-Hua, Wang, Ying-Kai, Yang, Fukang, Yang, Xuejie, Meanwell, Nicholas A., Snyder, Lawrence B.

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Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid by Meanwell, Nicholas A, Romine, Jeffrey L, Rosenfeld, Michael J, Martin, Scott W, Trehan, Ashok K, Wright, J. J. Kim, Malley, Mary F, Gougoutas, Jack Z, Brassard, Catherine L

“…cis-[3-[2-(4,5-Diphenyl-2-oxazolyl)ethenyl]phenoxy]acetic acid (3) was previously identified as a nonprostanoid prostacyclin (PGI2) mimetic that potently…”
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A rapid and efficient synthesis of chiral 2-hydro-2-oxazolines by Leonard, William R, Romine, Jeffrey L, Meyers, A. I

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