Search Results - "Romijn, Fred"

The Time Has Come for Quantitative Protein Mass Spectrometry Tests That Target Unmet Clinical Needs by Smit, Nico P. M, Ruhaak, L. Renee, Romijn, Fred P. H. T. M, Pieterse, Mervin M, van der Burgt, Yuri E. M, Cobbaert, Christa M

“…Protein mass spectrometry (MS) is an enabling technology that is ideally suited for precision diagnostics. In contrast to immunoassays with indirect readouts,…”
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Development and Provisional Validation of a Multiplex LC-MRM-MS Test for Timely Kidney Injury Detection in Urine by van Duijl, Tirsa T, Ruhaak, L. Renee, Smit, Nico P. M, Pieterse, Mervin M, Romijn, Fred P. H. T. M, Dolezal, Natasja, Drijfhout, Jan Wouter, de Fijter, Johan W, Cobbaert, Christa M

“…Kidney injury is a complication frequently encountered in hospitalized patients. Early detection of kidney injury prior to loss of renal function is an unmet…”
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Quantitative protein mass-spectrometry requires a standardized pre-analytical phase by Smit, Nico P M, Romijn, Fred P H T M, van Ham, Vanessa J J, Reijnders, Esther, Cobbaert, Christa M, Ruhaak, L Renee

“…Quantitative protein mass-spectrometry (QPMS) in blood depends on tryptic digestion of proteins and subsequent measurement of representing peptides. Whether…”
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Automated Multiplex LC-MS/MS Assay for Quantifying Serum Apolipoproteins A-I, B, C-I, C-II, C-III, and E with Qualitative Apolipoprotein E Phenotyping by van den Broek, Irene, Romijn, Fred P H T M, Nouta, Jan, van der Laarse, Arnoud, Drijfhout, Jan W, Smit, Nico P M, van der Burgt, Yuri E M, Cobbaert, Christa M

“…Direct and calculated measures of lipoprotein fractions for cardiovascular risk assessment suffer from analytical inaccuracy in certain dyslipidemic and…”
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The predictive value of TIMP-2 and IGFBP7 for kidney failure and 30-day mortality after elective cardiac surgery by Esmeijer, Kevin, Schoe, Abraham, Ruhaak, L. Renee, Hoogeveen, Ellen K., Soonawala, Darius, Romijn, Fred P. H. T. M., Shirzada, Maryam R., van Dissel, Jaap T., Cobbaert, Christa M., de Fijter, Johan W.

“…Acute kidney injury (AKI) is an important risk factor for chronic kidney disease, renal replacement therapy (RRT), and mortality. However, predicting AKI with…”
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Development of an LC-MRM-MS-Based Candidate Reference Measurement Procedure for Standardization of Serum Apolipoprotein (a) Tests by Ruhaak, L Renee, Romijn, Fred P H T M, Begcevic Brkovic, Ilijana, Kuklenyik, Zsusanna, Dittrich, Julia, Ceglarek, Uta, Hoofnagle, Andrew N, Althaus, Harald, Angles-Cano, Eduardo, Coassin, Stefan, Delatour, Vincent, Deprez, Liesbet, Dikaios, Ioannis, Kostner, Gerhard M, Kronenberg, Florian, Lyle, Alicia, Prinzing, Urban, Vesper, Hubert W, Cobbaert, Christa M

“…Medical results generated by European CE Marking for In Vitro Diagnostic or in-house tests should be traceable to higher order reference measurement systems…”
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Robust and Accurate 2-Year Performance of a Quantitative Mass Spectrometry-Based Apolipoprotein Test in a Clinical Chemistry Laboratory by Ruhaak, L Renee, Smit, Nico P M, Romijn, Fred P H T M, Pieterse, Mervin M, van der Laarse, Arnoud, van der Burgt, Yuri E M, Cobbaert, Christa M

“…Analytical method validation was performed according to the Clinical and Laboratory Standards Institute (CLSI) protocols, and the intraassay CVs were 2.3% to…”
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Quantifying Protein Measurands by Peptide Measurements: Where Do Errors Arise? by van den Broek, Irene, Romijn, Fred P.H.T.M, Smit, Nico P.M, van der Laarse, Arnoud, Drijfhout, Jan W, van der Burgt, Yuri E.M, Cobbaert, Christa M

“…Clinically actionable quantification of protein biomarkers by mass spectrometry (MS) requires analytical performance in concordance with quality specifications…”
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Urinary Kidney Injury Biomarkers Are Associated with Ischemia-Reperfusion Injury Severity in Kidney Allograft Recipients by van Duijl, Tirsa T, de Rooij, Esther N M, Treep, Maxim M, Koelemaij, Marte E, Romijn, Fred P H T M, Hoogeveen, Ellen K, Ruhaak, L Renee, le Cessie, Saskia, de Fijter, Johan W, Cobbaert, Christa M

“…Abstract Background We explored the potential of emerging and conventional urinary kidney injury biomarkers in recipients of living donor (LD) or donation…”
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An LC-MS-based designated comparison method with similar performance to the Lp(a) reference measurement procedure to guide molar Lp(a) standardization by Diederiks, Nina M, Ruhaak, L Renee, Romijn, Fred P H T M, Pieterse, Mervin M, Smit, Nico P M, Cobbaert, Christa M

“…The 2022 consensus statement of the European Atherosclerosis Society (EAS) on lipoprotein(a) (Lp(a)) recognizes the role of Lp(a) as a relevant genetically…”
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Tissue factor-bearing microparticles and CA19.9: two players in pancreatic cancer-associated thrombosis? by Woei-A-Jin, F J Sherida H, Tesselaar, Margot E T, Garcia Rodriguez, Patrica, Romijn, Fred P H T M, Bertina, Rogier M, Osanto, Susanne

“…Background: Cancer-related venous thromboembolism (VTE) heralds a poor prognosis, especially in pancreatic adenocarcinoma (PAC). Tissue factor (TF) is…”
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MS-based proteomics: a metrological sound and robust alternative for apolipoprotein E phenotyping in a multiplexed test by Ruhaak, L Renee, Smit, Nico P M, Suchiman, H Eka D, Pieterse, Mervin M, Romijn, Fred P H T M, Beekman, Marian, Cobbaert, Christa M

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Urinary beta-2 microglobulin increases whereas TIMP-2 and IGFBP7 decline after unilateral nephrectomy in healthy kidney donors by de Rooij, Esther N. M., Hoogeveen, Ellen K., Romijn, Fred P. H. T. M., van der Kooy, Sandra W., Veighey, Kristin V., Dekker, Friedo W., van Kooten, Cees, Cobbaert, Christa M., de Fijter, Johan W.

“…Early kidney injury may be detected by urinary markers, such as beta-2 microglobulin (B2M), tissue inhibitor of metalloproteinases-2 (TIMP-2), insulin-like…”
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Apolipoproteins A1, B, and apoB/apoA1 ratio are associated with first ST-segment elevation myocardial infarction but not with recurrent events during long-term follow-up by Bodde, Mathijs C., Hermans, Maaike P. J., Jukema, J. Wouter, Schalij, Martin J., Lijfering, Willem M., Rosendaal, Frits R., Romijn, Fred P. H. T. M., Ruhaak, L. Renee, van der Laarse, Arnoud, Cobbaert, Christa M.

“…Introduction The current way to assess the risk of cardiovascular disease (CVD) is to measure conventional lipid and lipoprotein cholesterol fractions. Despite…”
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Urinary TIMP-2 Predicts the Presence and Duration of Delayed Graft Function in Donation After Circulatory Death Kidney Transplant Recipients by Bank, Jonna R, Ruhaak, Renée, Soonawala, Darius, Mayboroda, Oleg, Romijn, Fred P, van Kooten, Cees, Cobbaert, Christa M, de Fijter, Johan W

“…BACKGROUND.Urinary tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor binding protein-7 (IGFBP7) have been validated as…”
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Detecting molecular forms of antithrombin by LC-MRM-MS: defining the measurands by Ruhaak, L Renee, Romijn, Fred P H T M, Smit, Nico P M, van der Laarse, Arnoud, Pieterse, Mervin M, de Maat, Moniek P M, Haas, Fred J L M, Kluft, Cornelis, Amiral, Jean, Meijer, Piet, Cobbaert, Christa M

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Evaluation of Interspecimen Trypsin Digestion Efficiency Prior to Multiple Reaction Monitoring-Based Absolute Protein Quantification with Native Protein Calibrators by van den Broek, Irene, Smit, Nico P. M, Romijn, Fred P. H. T. M, van der Laarse, Arnoud, Deelder, André M, van der Burgt, Yuri E. M, Cobbaert, Christa M

“…Implementation of quantitative clinical chemistry proteomics (qCCP) requires targeted proteomics approaches, usually involving bottom-up multiple reaction…”
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Short-term cooling increases serum triglycerides and small high-density lipoprotein levels in humans by Hoeke, Geerte, Nahon, Kimberly J, Bakker, Leontine E.H, Norkauer, Sabine S.C, Dinnes, Donna L.M, Kockx, Maaike, Lichtenstein, Laeticia, Drettwan, Diana, Reifel-Miller, Anne, Coskun, Tamer, Pagel, Philipp, Romijn, Fred P.H.T.M, Cobbaert, Christa M, Jazet, Ingrid M, Martinez, Laurent O, Kritharides, Leonard, Berbée, Jimmy F.P, Boon, Mariëtte R, Rensen, Patrick C.N

“…Background Cold exposure and β3-adrenergic receptor agonism, which both activate brown adipose tissue, markedly influence lipoprotein metabolism by enhancing…”
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Quantification of serum apolipoproteins A-I and B-100 in clinical samples using an automated SISCAPA–MALDI-TOF-MS workflow by van den Broek, Irene, Nouta, Jan, Razavi, Morteza, Yip, Richard, Bladergroen, Marco R., Romijn, Fred P.H.T.M., Smit, Nico P.M., Drews, Oliver, Paape, Rainer, Suckau, Detlev, Deelder, André M., van der Burgt, Yuri E.M., Pearson, Terry W., Anderson, N. Leigh, Cobbaert, Christa M.

“…[Display omitted] •A fully-automated SISCAPA–MALDI-TOF-MS assay was developed for apoA-I and apoB-100.•The assay allowed processing and analysis of 96 samples…”
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Metrological traceability in mass spectrometry-based targeted protein quantitation: A proof-of-principle study for serum apolipoproteins A-I and B100 by Smit, Nico P.M., Romijn, Fred P.H.T.M., van den Broek, Irene, Drijfhout, Jan W., Haex, Martin, van der Laarse, Arnoud, van der Burgt, Yuri E.M., Cobbaert, Christa M.

“…In this study, we have followed up on previous liquid chromatography (LC) multiple reaction monitoring (MRM) mass spectrometry (MS) approaches for measurement…”
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