Search Results - "Romey, G"

TREK-1, a K+ channel involved in neuroprotection and general anesthesia by Heurteaux, C, Guy, N, Laigle, C, Blondeau, N, Duprat, F, Mazzuca, M, Lang-Lazdunski, L, Widmann, C, Zanzouri, M, Romey, G, Lazdunski, M

“…TREK‐1 is a two‐pore‐domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and…”
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Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels by Lazdunski, Michel, Chemin, Jean, Girard, Christophe, Duprat, Fabrice, Lesage, Florian, Romey, Georges

“…Group I metabotropic glutamate receptors (mGluRs) are implicated in diverse processes such as learning, memory, epilepsy, pain and neuronal death. By…”
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Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel by Fink, M., Duprat, F., Lesage, F., Reyes, R., Romey, G., Heurteaux, C., Lazdunski, M.

“…Human TWIK‐1, which has been cloned recently, is a new structural type of weak inward rectifier K+ channel. Here we report the structural and functional…”
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TWIK‐1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure by Lesage, F., Guillemare, E., Fink, M., Duprat, F., Lazdunski, M., Romey, G., Barhanin, J.

“…A new human weakly inward rectifying K+ channel, TWIK‐1, has been isolated. This channel is 336 amino acids long and has four transmembrane domains. Unlike…”
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p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1 by Girard, Christophe, Tinel, Norbert, Terrenoire, Cécile, Romey, Georges, Lazdunski, Michel, Borsotto, Marc

“…TASK‐1 belongs to the 2P domain K+ channel family and is the prototype of background K+ channels that set the resting membrane potential and tune action…”
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Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias by Chouabe, Christophe, Neyroud, Nathalie, Guicheney, Pascale, Lazdunski, Michel, Romey, Georges, Barhanin, Jacques

“…Mutations in the delayed rectifier K+ channel subunit KvLQT1 have been identified as responsible for both Romano–Ward (RW) and Jervell and Lange‐Nielsen (JLN)…”
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Genomic and Functional Characteristics of Novel Human Pancreatic 2P Domain K+ Channels by Girard, Christophe, Duprat, Fabrice, Terrenoire, Cécile, Tinel, Norbert, Fosset, Michel, Romey, Georges, Lazdunski, Michel, Lesage, Florian

“…We isolated three novel 2P domain K+ channel subunits from human. The first two subunits, TALK-1 and TALK-2, are distantly related to TASK-2. Their genes form…”
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PP2A-Bγ subunit and KCNQ2 K+ channels in bipolar disorder by Borsotto, M, Cavarec, L, Bouillot, M, Romey, G, Macciardi, F, Delaye, A, Nasroune, M, Bastucci, M, Sambucy, J-L, Luan, J-J, Charpagne, A, Jouet, V, Leger, R, Lazdunski, M, Cohen, D, Chumakov, I

“…Many bipolar affective disorder (BD) susceptibility loci have been identified but the molecular mechanisms responsible for the disease remain to be elucidated…”
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The bee venom peptide tertiapin underlines the role of I(KACh) in acetylcholine-induced atrioventricular blocks by Drici, M D, Diochot, S, Terrenoire, C, Romey, G, Lazdunski, M

“…Acetylcholine (ACh) is an important neuromodulator of cardiac function that is released upon stimulation of the vagus nerve. Despite numerous reports on…”
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Effects of a mosquitocidal toxin on a mammalian epithelial cell line expressing its target receptor by Pauchet, Yannick, Luton, Frédéric, Castella, Claude, Charles, Jean‐François, Romey, Georges, Pauron, David

“…Summary The spread of diseases transmitted by Anopheles and Culex mosquitoes, such as malaria and West Nile fever, is a growing concern for human health…”
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Susceptibility of Cloned K+Channels to Reactive Oxygen Species by Duprat, Fabrice, Guillemare, Eric, Romey, Georges, Fink, Michel, Lesage, Florian, Lazdunski, Michel, Honore, Eric

“…Free radical-induced oxidant stress has been implicated in a number of physiological and pathophysiological states including ischemia and reperfusion-induced…”
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Heterologous Multimeric Assembly Is Essential for K+ Channel Activity of Neuronal and Cardiac G-Protein-Activated Inward Rectifiers by Duprat, F., Lesage, F., Guillemare, E., Fink, M., Hugnot, J.P., Bigay, J., Lazdunski, M., Romey, G., Barhanin, J.

“…The family of G-protein-activated inward-rectifiers K+ channels presently comprise at least 3 cloned members called GIRK1, GIRK2 and GIRK3. A close structural…”
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Calcicludine, A Venom Peptide of the Kunitz-Type Protease Inhibitor Family, is a Potent Blocker of High-Threshold Ca2+Channels with a High Affinity for L-Type Channels in Cerebellar Granule Neurons by Schweitz, Hugues, Heurteaux, Catherine, Bois, Patrick, Moinier, Danielle, Romey, Georges, Lazdunski, Michel

“…Calcicludine (CaC) is a 60-amino acid polypeptide from the venom of Dendroaspis angusticeps. It is structurally homologous to the Kunitz-type protease…”
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Mice display sex differences in halothane-induced polymorphic ventricular tachycardia by DRICI, Milou-Daniel, BAKER, Linda, PLAN, Patricia, BARHANIN, Jacques, ROMEY, Georges, SALAMA, Guy

“…Molecularly engineered mice are extensively used as models of cardiovascular diseases, yet little is known about sex differences in the electrophysiology of…”
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Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart by Honoré, E., Attali, B., Romey, G., Heurteaux, C., Ricard, P., Lesage, F., Lazdunski, M., Barhanin, J.

“…Neonatal mouse cardiac poly(A)+ mRNA microinjection into Xenopus oocytes directed the expression of a delayed rectifier K+ current. A cDNA encoding this…”
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PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder by Borsotto, M, Cavarec, L, Bouillot, M, Romey, G, Macciardi, F, Delaye, A, Nasroune, M, Bastucci, M, Sambucy, J-L, Luan, J-J, Charpagne, A, Jouët, V, Léger, R, Lazdunski, M, Cohen, D, Chumakov, I

“…Many bipolar affective disorder (BD) susceptibility loci have been identified but the molecular mechanisms responsible for the disease remain to be elucidated…”
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Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes by ATTALI, ROMEY, G, HONORE, E, SCHMID-ALLIANA, A, MATTEI, M.-G, LESAGE, F, RICARD, P, BARHANIN, J, LAZDUNSKI, M

“…Low stringency screening of a Jurkat cDNA library with a rat brain K+ channel (RCK1) probe has resulted in the isolation of HLK3, a voltage-gated K+ channel…”
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Vasopressin Modulates the Spontaneous Electrical Activity in Aortic Cells (Line A7r5) by Acting on Three Different Types of Ionic Channels by Van Renterghem, Catherine, Romey, Georges, Lazdunski, Michel

“…A7r5 smooth muscle (aorta) cells have a spontaneous electrical activity. Application of vasopressin produces a hyperpolarization accompanied by an interruption…”
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Effects of a new class of calcium antagonists, SR33557 (fantofarone) and SR33805, on neuronal voltage-activated Ca++ channels by Romey, G, Lazdunski, M

“…SR33557 (fantofarone) and SR33805 are structurally novel calcium antagonists that bind selectively to the alpha 1-subunit of the L-type Ca++ channel at a site…”
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Apamin as a Selective Blocker of the Calcium-Dependent Potassium Channel in Neuroblastoma Cells: Voltage-Clamp and Biochemical Characterization of the Toxin Receptor by Hugues, M., Romey, G., Duval, D., Vincent, J. P., Lazdunski, M.

“…This paper describes the interaction of apamin, a bee venom neurotoxin, with the mouse neuroblastoma cell membrane. Voltage-clamp analyses have shown that…”
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