Search Results - "Romero, Iris L."

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers by Liu, Xiaojing, Romero, Iris L., Litchfield, Lacey M., Lengyel, Ernst, Locasale, Jason W.

“…Repurposing metformin for cancer therapy is attractive due to its safety profile, epidemiological evidence, and encouraging data from human clinical trials…”
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Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance by Mukherjee, Abir, Chiang, Chun-Yi, Daifotis, Helen A, Nieman, Kristin M, Fahrmann, Johannes F, Lastra, Ricardo R, Romero, Iris L, Fiehn, Oliver, Lengyel, Ernst

“…Adipocytes are critical for ovarian cancer cells to home to the omentum, but the metabolic changes initiated by this interaction are unknown. To this end, we…”
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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth by Nieman, Kristin M, Kenny, Hilary A, Penicka, Carla V, Ladanyi, Andras, Buell-Gutbrod, Rebecca, Zillhardt, Marion R, Romero, Iris L, Carey, Mark S, Mills, Gordon B, Hotamisligil, Gökhan S, Yamada, S Diane, Peter, Marcus E, Gwin, Katja, Lengyel, Ernst

“…Ovarian tumors preferentially metastasize to the omentum, a peritoneal fat layer. This report proposes that the reasons for this predilection stem from the…”
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Old drug, new trick: Repurposing metformin for gynecologic cancers? by Febbraro, Terri, Lengyel, Ernst, Romero, Iris L

“…Abstract Objective There is increasing pre-clinical and clinical evidence that metformin, a commonly used diabetes medication, has a protective effect in…”
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Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion by Kenny, Hilary A, Chiang, Chun-Yi, White, Erin A, Schryver, Elizabeth M, Habis, Mohammed, Romero, Iris L, Ladanyi, Andras, Penicka, Carla V, George, Joshy, Matlin, Karl, Montag, Anthony, Wroblewski, Kristen, Yamada, S Diane, Mazar, Andrew P, Bowtell, David, Lengyel, Ernst

“…Ovarian cancer (OvCa) metastasizes to organs in the abdominal cavity, such as the omentum, which are covered by a single layer of mesothelial cells…”
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Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models by Lengyel, Ernst, MD, Litchfield, Lacey M., PhD, Mitra, Anirban K., PhD, Nieman, Kristin M., PhD, Mukherjee, Abir, PhD, Zhang, Yilin, PhD, Johnson, Alyssa, BS, Bradaric, Michael, PhD, Lee, WooSeok, MD, Romero, Iris L., MD

“…Objective There is increasing preclinical evidence indicating that metformin, a medication commonly used for type 2 diabetes mellitus, may protect against…”
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Molecular pathways: trafficking of metabolic resources in the tumor microenvironment by Romero, Iris L, Mukherjee, Abir, Kenny, Hilary A, Litchfield, Lacey M, Lengyel, Ernst

“…A model of tumor metabolism is proposed that describes how the complementary metabolic functions of the local stroma and the tumor cells contribute to cancer…”
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SPHK1 Is a Novel Target of Metformin in Ovarian Cancer by Hart, Peter C, Chiyoda, Tatsuyuki, Liu, Xiaojing, Weigert, Melanie, Curtis, Marion, Chiang, Chun-Yi, Loth, Rachel, Lastra, Ricardo, McGregor, Stephanie M, Locasale, Jason W, Lengyel, Ernst, Romero, Iris L

“…The role of phospholipid signaling in ovarian cancer is poorly understood. Sphingosine-1-phosphate (S1P) is a bioactive metabolite of sphingosine that has been…”
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Relationship of Type II Diabetes and Metformin Use to Ovarian Cancer Progression, Survival, and Chemosensitivity by Romero, Iris L, McCormick, Anna, McEwen, Kelsey A, Park, SeoYoung, Karrison, Theodore, Yamada, S Diane, Pannain, Silvana, Lengyel, Ernst

“…OBJECTIVE:To estimate whether metformin use by ovarian cancer patients with type II diabetes was associated with improved survival. METHODS:We reviewed the…”
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Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk by Hart, Peter C., Kenny, Hilary A., Grassl, Niklas, Watters, Karen M., Litchfield, Lacey M., Coscia, Fabian, Blaženović, Ivana, Ploetzky, Lisa, Fiehn, Oliver, Mann, Matthias, Lengyel, Ernst, Romero, Iris L.

“…The tumor microenvironment (TME) plays a pivotal role in cancer progression, and, in ovarian cancer (OvCa), the primary TME is the omentum. Here, we show that…”
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Association of Metformin Use with Outcomes in Advanced Endometrial Cancer Treated with Chemotherapy by Ezewuiro, Obiageli, Grushko, Tatyana A, Kocherginsky, Masha, Habis, Mohammed, Hurteau, Jean A, Mills, Kathryn A, Hunn, Jessica, Olopade, Olufunmilayo I, Fleming, Gini F, Romero, Iris L

“…There is increasing evidence that metformin, a commonly used treatment for diabetes, might have the potential to be repurposed as an economical and safe cancer…”
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Foretinib (GSK1363089), an Orally Available Multikinase Inhibitor of c-Met and VEGFR-2, Blocks Proliferation, Induces Anoikis, and Impairs Ovarian Cancer Metastasis by ZILLHARDT, Marion, PARK, Sun-Mi, ROMERO, Iris L, SAWADA, Kenjiro, MONTAG, Anthony, KRAUSZ, Thomas, YAMADA, S. Diane, PETER, Marcus E, LENGYEL, Ernst

“…Currently, there are no approved targeted therapies for the treatment of ovarian cancer, despite the fact that it is the most lethal gynecological malignancy…”
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Statin therapy is associated with improved survival in patients with non-serous-papillary epithelial ovarian cancer: a retrospective cohort analysis by Habis, Mohammed, Wroblewski, Kristen, Bradaric, Michael, Ismail, Nadia, Yamada, S Diane, Litchfield, Lacey, Lengyel, Ernst, Romero, Iris L

“…To determine whether statin use is associated with improved epithelial ovarian cancer (OvCa) survival. This is a single-institution retrospective cohort review…”
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Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention by Chiyoda, Tatsuyuki, Hart, Peter C, Eckert, Mark A, McGregor, Stephanie M, Lastra, Ricardo R, Hamamoto, Ryuji, Nakamura, Yusuke, Yamada, S Diane, Olopade, Olufunmilayo I, Lengyel, Ernst, Romero, Iris L

“…Mutations in the breast cancer susceptibility gene 1 ( ) are associated with an increased risk of developing epithelial ovarian cancer. However, beyond the…”
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Adipose tissue and adipocytes support tumorigenesis and metastasis by Nieman, Kristin M., Romero, Iris L., Van Houten, Bennett, Lengyel, Ernst

“…Adipose tissue influences tumor development in two major ways. First, obese individuals have a higher risk of developing certain cancers (endometrial,…”
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Changes in numbers and academic ranks of Hispanic faculty in departments of obstetrics and gynecology by Xierali, Imam M., Romero, Iris L., Rayburn, William F.

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Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer by Bowtell, David D., Böhm, Steffen, Ahmed, Ahmed A., Aspuria, Paul-Joseph, Bast, Robert C., Beral, Valerie, Berek, Jonathan S., Birrer, Michael J., Blagden, Sarah, Bookman, Michael A., Brenton, James D., Chiappinelli, Katherine B., Martins, Filipe Correia, Coukos, George, Drapkin, Ronny, Edmondson, Richard, Fotopoulou, Christina, Gabra, Hani, Galon, Jérôme, Gourley, Charlie, Heong, Valerie, Huntsman, David G., Iwanicki, Marcin, Karlan, Beth Y., Kaye, Allyson, Lengyel, Ernst, Levine, Douglas A., Lu, Karen H., McNeish, Iain A., Menon, Usha, Narod, Steven A., Nelson, Brad H., Nephew, Kenneth P., Pharoah, Paul, Powell, Daniel J., Ramos, Pilar, Romero, Iris L., Scott, Clare L., Sood, Anil K., Stronach, Euan A., Balkwill, Frances R.

“…This Opinion article outlines a set of research priorities, based on discussions held at the 2015 Helene Harris Memorial Trust Ovarian Cancer Action meeting,…”
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CD95 promotes tumour growth by Peter, Marcus E, Chen, Lina, Park, Sun-Mi, Tumanov, Alexei V, Hau, Annika, Sawada, Kenjiro, Feig, Christine, Turner, Jerrold R, Fu, Yang-Xin, Romero, Iris L, Lengyel, Ernst

“…CD95 (also called Fas and APO-1) is a prototypical death receptor that regulates tissue homeostasis mainly in the immune system through the induction of…”
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Intensive Surveillance with Biannual Dynamic Contrast-Enhanced Magnetic Resonance Imaging Downstages Breast Cancer in BRCA1 Mutation Carriers by Guindalini, Rodrigo Santa Cruz, Zheng, Yonglan, Abe, Hiroyuki, Whitaker, Kristen, Yoshimatsu, Toshio F, Walsh, Tom, Schacht, David, Kulkarni, Kirti, Sheth, Deepa, Verp, Marion S, Bradbury, Angela R, Churpek, Jane, Obeid, Elias, Mueller, Jeffrey, Khramtsova, Galina, Liu, Fang, Raoul, Akila, Cao, Hongyuan, Romero, Iris L, Hong, Susan, Livingston, Robert, Jaskowiak, Nora, Wang, Xiaoming, Debiasi, Marcio, Pritchard, Colin C, King, Mary-Claire, Karczmar, Gregory, Newstead, Gillian M, Huo, Dezheng, Olopade, Olufunmilayo I

“…To establish a cohort of high-risk women undergoing intensive surveillance for breast cancer. We performed dynamic contrast-enhanced MRI every 6 months in…”
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Obstetrics and Gynecology Resident Physician Experiences with Lesbian, Gay, Bisexual, Transgender and Queer Healthcare Training by Guerrero-Hall, Karla Daniela, Muscanell, Rebecca, Garg, Namrata, Romero, Iris L., Chor, Julie

“…Purpose To assess obstetrician-gynecologist (Ob/Gyn) resident experiences with and preferences for lesbian, gay, bisexual, transgender, and queer (LGBTQ)…”
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