Search Results - "Romero, Ignacio A."

The hCMEC/D3 cell line as a model of the human blood brain barrier by Weksler, Babette, Romero, Ignacio A, Couraud, Pierre-Olivier

“…Since the first attempts in the 1970s to isolate cerebral microvessel endothelial cells (CECs) in order to model the blood-brain barrier (BBB) in vitro, the…”
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Development of a three-dimensional, all-human in vitro model of the blood–brain barrier using mono-, co-, and tri-cultivation Transwell models by Hatherell, Kathryn, Couraud, Pierre-Olivier, Romero, Ignacio A., Weksler, Babette, Pilkington, Geoffrey J.

“…► Mono-, co-, and tri-culture models have been developed. ► Models constructed use only human components. ► All co- and tri-culture models gave significantly…”
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A hydrogel model of the human blood-brain barrier using differentiated stem cells by Singh, Nandita Rahatekar, Gromnicova, Radka, Brachner, Andreas, Kraev, Igor, Romero, Ignacio A, Neuhaus, Winfried, Male, David

“…An in vitro model of the human blood-brain barrier was developed, based on a collagen hydrogel containing astrocytes, overlaid with a monolayer of endothelium,…”
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Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro by Gromnicova, Radka, Davies, Heather A, Sreekanthreddy, Peddagangannagari, Romero, Ignacio A, Lund, Torben, Roitt, Ivan M, Phillips, James B, Male, David K

“…The blood-brain barrier prevents the entry of many therapeutic agents into the brain. Various nanocarriers have been developed to help agents to cross this…”
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Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice by Lopez-Ramirez, Miguel Alejandro, Pham, Angela, Girard, Romuald, Wyseure, Tine, Hale, Preston, Yamashita, Atsuki, Koskimäki, Janne, Polster, Sean, Saadat, Laleh, Romero, Ignacio A., Esmon, Charles T., Lagarrigue, Frederic, Awad, Issam A., Mosnier, Laurent O., Ginsberg, Mark H.

“…Cerebral cavernous malformations (CCMs) are common brain vascular dysplasias that are prone to acute and chronic hemorrhage with significant clinical sequelae…”
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Identification of an essential endogenous regulator of blood–brain barrier integrity, and its pathological and therapeutic implications by Cristante, Enrico, McArthur, Simon, Mauro, Claudio, Maggioli, Elisa, Romero, Ignacio A., Wylezinska-Arridge, Marzena, Couraud, Pierre O., Lopez-Tremoleda, Jordi, Christian, Helen C., Weksler, Babette B., Malaspina, Andrea, Solito, Egle

“…The blood–brain barrier (BBB), a critical guardian of communication between the periphery and the brain, is frequently compromised in neurological diseases…”
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Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4 by Duperray, Alain, Barbe, Delphin, Raguenez, Gilda, Weksler, Babette B, Romero, Ignacio A, Couraud, Pierre-Olivier, Perron, Hervé, Marche, Patrice N

“…The MSRV (multiple sclerosis-associated retrovirus) belongs to the human endogenous retrovirus HERV-W family. The envelope protein originating from the MSRV…”
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Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues by Gromnicova, Radka, Kaya, Mehmet, Romero, Ignacio A, Williams, Phil, Satchell, Simon, Sharrack, Basil, Male, David

“…The selective entry of nanoparticles into target tissues is the key factor which determines their tissue distribution. Entry is primarily controlled by…”
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A human-derived neurovascular unit in vitro model to study the effects of cellular cross-talk and soluble factors on barrier integrity by Barberio, Chiara, Withers, Aimee, Mishra, Yash, Couraud, Pierre-Olivier, Romero, Ignacio A, Weksler, Babette, Owens, Róisín M

“…The blood-brain barrier (BBB) restricts paracellular and transcellular diffusion of compounds and is part of a dynamic multicellular structure known as the…”
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Early alterations of Hedgehog signaling pathway in vascular endothelial cells after peripheral nerve injury elicit blood-nerve barrier disruption, nerve inflammation, and neuropathic pain development by Moreau, Nathan, Mauborgne, Annie, Bourgoin, Sylvie, Couraud, Pierre-Olivier, Romero, Ignacio A., Weksler, Babette B., Villanueva, Luis, Pohl, Michel, Boucher, Yves

“…Changes in the nerve's microenvironment and local inflammation resulting from peripheral nerve injury participate in nerve sensitization and neuropathic pain…”
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IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF by Cerutti, Camilla, Lucotti, Serena, Menendez, Sofia T., Reymond, Nicolas, Garg, Ritu, Romero, Ignacio A., Muschel, Ruth, Ridley, Anne J.

“…Attachment of circulating tumor cells to the endothelial cells (ECs) lining blood vessels is a critical step in cancer metastatic colonization, which leads to…”
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Methamphetamine disrupts blood-brain barrier function by induction of oxidative stress in brain endothelial cells by Ramirez, Servio H, Potula, Raghava, Fan, Shongshan, Eidem, Tess, Papugani, Anil, Reichenbach, Nancy, Dykstra, Holly, Weksler, Babette B, Romero, Ignacio A, Couraud, Pierre O, Persidsky, Yuri

“…Methamphetamine (METH), a potent stimulant with strong euphoric properties, has a high abuse liability and long-lasting neurotoxic effects. Recent studies in…”
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Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway by Vukic, Vanja, Callaghan, Debbie, Walker, Douglas, Lue, Lih-Fen, Liu, Qing Yan, Couraud, Pierre-Oliver, Romero, Ignacio A, Weksler, Babette, Stanimirovic, Danica B, Zhang, Wandong

“…Abstract Alzheimer's disease (AD) is characterized by accumulation and deposition of Aβ peptides in the brain. Aβ deposition in cerebral vessels occurs in many…”
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Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells by Lopez-Ramirez, M Alejandro, Fischer, Roman, Torres-Badillo, Claudia C, Davies, Heather A, Logan, Karen, Pfizenmaier, Klaus, Male, David K, Sharrack, Basil, Romero, Ignacio A

“…During neuroinflammation, cytokines such as TNF-α and IFN-γ secreted by activated leukocytes and/or CNS resident cells have been shown to alter the phenotype…”
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Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier by Fletcher, Nicola F, Wilson, Garrick K, Murray, Jacinta, Hu, Ke, Lewis, Andrew, Reynolds, Gary M, Stamataki, Zania, Meredith, Luke W, Rowe, Ian A, Luo, Guangxiang, Lopez–Ramirez, Miguel A, Baumert, Thomas F, Weksler, Babette, Couraud, Pierre–Olivier, Kim, Kwang Sik, Romero, Ignacio A, Jopling, Catherine, Morgello, Susan, Balfe, Peter, McKeating, Jane A

“…Background & Aims Hepatitis C virus (HCV) infection leads to progressive liver disease and is associated with a variety of extrahepatic syndromes, including…”
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Meningococcal Type IV Pili Recruit the Polarity Complex to Cross the Brain Endothelium by Coureuil, Mathieu, Mikaty, Guillain, Miller, Florence, Lécuyer, Hervé, Bernard, Christine, Bourdoulous, Sandrine, Duménil, Guillaume, Mège, René-Marc, Weksler, Babette B, Romero, Ignacio A, Couraud, Pierre-Olivier, Nassif, Xavier

“…Type IV pili mediate the initial interaction of many bacterial pathogens with their host cells. In Neisseria meningitidis, the causative agent of cerebrospinal…”
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MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis by Reijerkerk, Arie, Lopez-Ramirez, M Alejandro, van Het Hof, Bert, Drexhage, Joost A R, Kamphuis, Wouter W, Kooij, Gijs, Vos, Joost B, van der Pouw Kraan, Tineke C T M, van Zonneveld, Anton J, Horrevoets, Anton J, Prat, Alexandre, Romero, Ignacio A, de Vries, Helga E

“…Blood-brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we…”
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The role of perivascular innervation and neurally mediated vasoreactivity in the pathophysiology of Alzheimer's disease by Nizari, Shereen, Romero, Ignacio A, Hawkes, Cheryl A

“…Neuronal death is a hallmark of Alzheimer's disease (AD) and considerable work has been done to understand how the loss of interconnectivity between neurons…”
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Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier by Daniels, Brian P., Cruz-Orengo, Lillian, Pasieka, Tracy Jo, Couraud, Pierre-Olivier, Romero, Ignacio A., Weksler, Babette, Cooper, John A., Doering, Tamara L., Klein, Robyn S.

“…► We validate the use of an immortalized blood brain barrier cell line for use in studies of immune migration. ► The HCMEC/D3 endothelial cell line maintains…”
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MiR-126 and miR-126 regulate shear-resistant firm leukocyte adhesion to human brain endothelium by Cerutti, Camilla, Edwards, Laura J., de Vries, Helga E., Sharrack, Basil, Male, David K., Romero, Ignacio A.

“…Leukocyte adhesion to brain endothelial cells, the blood-brain barrier main component, is a critical step in the pathogenesis of neuroinflammatory diseases…”
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