Search Results - "Romee, Rizwan"
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CAR-NK cells: A promising cellular immunotherapy for cancer
Published in EBioMedicine (01-09-2020)“…Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can kill target cells through similar cytotoxic mechanisms. With the…”
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Cytokine-induced memory-like natural killer cells for cancer immunotherapy
Published in Stem cell research & therapy (04-12-2021)“…Natural killer cells are an important part of the innate immune system mediating robust responses to virus-infected and malignant cells without needing prior…”
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TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes
Published in The New England journal of medicine (24-11-2016)“…Decitabine produced responses in patients with acute myeloid leukemia or myelodysplastic syndromes who had cytogenetic abnormalities associated with a poor…”
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Cytokine activation induces human memory-like NK cells
Published in Blood (06-12-2012)“…Natural killer (NK) cells are lymphocytes that play an important role in the immune response to infection and malignancy. Recent studies in mice have shown…”
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NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)
Published in Blood (02-05-2013)“…The Fc receptor CD16 is present on essentially all CD56dim peripheral blood natural killer (NK) cells. Upon recognition of antibody-coated cells it delivers a…”
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Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia
Published in Science translational medicine (21-09-2016)“…Natural killer (NK) cells are an emerging cellular immunotherapy for patients with acute myeloid leukemia (AML); however, the best approach to maximize NK cell…”
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Innovative Strategies to Improve the Clinical Application of NK Cell-Based Immunotherapy
Published in Frontiers in immunology (25-03-2022)“…Natural killer cells constitute a part of the innate immune system that mediates an effective immune response towards virus-infected and malignant cells. In…”
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First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation
Published in Blood (07-06-2018)“…New therapies for patients with hematologic malignancies who relapse after allogeneic hematopoietic cell transplantation (allo-HCT) are needed. Interleukin 15…”
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CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia
Published in Nature biomedical engineering (01-05-2021)“…Therapies employing chimeric antigen receptor T cells (CAR-T cells) targeting tumour-associated antigens (TAAs) can lead to on-target–off-tumour toxicity and…”
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Cytokine release syndrome after haploidentical hematopoietic cell transplantation: an international multicenter analysis
Published in Bone marrow transplantation (Basingstoke) (01-11-2021)“…Haploidentical related donor transplantation (haplo-HCT) is associated with cytokine release syndrome (CRS). We conducted a multicenter retrospective study to…”
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Editorial: Innate immune cell therapy of cancer
Published in Frontiers in immunology (19-08-2022)Get full text
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The European Society for Blood and Marrow Transplantation (EBMT) consensus recommendations for donor selection in haploidentical hematopoietic cell transplantation
Published in Bone marrow transplantation (Basingstoke) (01-01-2020)“…The number of HLA-haploidentical hematopoietic cell transplants continues to increase worldwide due to recent improvements in outcomes, allowing more patients…”
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CD56bright NK cells exhibit potent antitumor responses following IL-15 priming
Published in The Journal of clinical investigation (01-11-2017)“…NK cells, lymphocytes of the innate immune system, are important for defense against infectious pathogens and cancer. Classically, the CD56dim NK cell subset…”
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Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse
Published in The Journal of clinical investigation (01-06-2022)“…BackgroundResponses to conventional donor lymphocyte infusion for postallogeneic hematopoietic cell transplantation (HCT) relapse are typically poor. Natural…”
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Key Aspects of the Immunobiology of Haploidentical Hematopoietic Cell Transplantation
Published in Frontiers in immunology (14-02-2020)“…Hematopoietic stem cell transplantation from a haploidentical donor is increasingly used and has become a standard donor option for patients lacking an…”
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Clinical applications of donor lymphocyte infusion from an HLA-haploidentical donor: consensus recommendations from the Acute Leukemia Working Party of the EBMT
Published in Haematologica (Roma) (01-01-2020)“…Donor lymphocyte infusion has been used in the management of relapsed hematologic malignancies after allogeneic hematopoietic cell transplantation. It can…”
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Epidemiology of infections following haploidentical peripheral blood hematopoietic cell transplantation
Published in Transplant infectious disease (01-02-2017)“…Background The use of T‐cell replete haploidentical hematopoietic cell transplant (haplo‐HCT) has increased substantially since the introduction of…”
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Allogeneic hematopoietic cell transplantation outcomes in patients with Richter's transformation
Published in Haematologica (Roma) (01-12-2021)Get full text
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ADAM17 and CD56lowCD16low NK cells
Published in Haematologica (Roma) (01-08-2015)Get full text
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