Search Results - "Romecín, Paola"

Flavonoids in Kidney Health and Disease by Vargas, Félix, Romecín, Paola, García-Guillén, Ana I, Wangesteen, Rosemary, Vargas-Tendero, Pablo, Paredes, M Dolores, Atucha, Noemí M, García-Estañ, Joaquín

“…This review summarizes the latest advances in knowledge on the effects of flavonoids on renal function in health and disease. Flavonoids have antihypertensive,…”
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Silk fibroin scaffolds seeded with Wharton's jelly mesenchymal stem cells enhance re-epithelialization and reduce formation of scar tissue after cutaneous wound healing by Millán-Rivero, José E, Martínez, Carlos M, Romecín, Paola A, Aznar-Cervantes, Salvador D, Carpes-Ruiz, Marina, Cenis, José L, Moraleda, Jose M, Atucha, Noemí M, García-Bernal, David

“…The treatment of extensive and/or chronic skin wounds is a widespread and costly public health problem. Mesenchymal stem cells (MSCs) have been proposed as a…”
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Role of Nitric Oxide in the Altered Calcium Homeostasis of Platelets from Rats with Biliary Cirrhosis by Akbari Aghdam, Masoud, Romecín, Paola, García-Estañ, Joaquín, Atucha, Noemí M

“…Previously, we found that intracellular calcium (Ca ) homeostasis is altered in platelets from an experimental model of liver cirrhosis, namely the…”
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Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in acute myeloid leukemia by Sánchez Martínez, Diego, Tirado, Néstor, Mensurado, Sofia, Martínez-Moreno, Alba, Romecín, Paola, Gutiérrez Agüera, Francisco, Correia, Daniel V, Silva-Santos, Bruno, Menéndez, Pablo

“…BackgroundChimeric antigen receptor (CAR)-T cells have emerged as a breakthrough treatment for relapse/refractory hematological tumors, showing impressive…”
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Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats by Paredes, M Dolores, Romecín, Paola, Atucha, Noemí M, O'Valle, Francisco, Castillo, Julián, Ortiz, M Clara, García-Estañ, Joaquín

“…we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks)…”
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Moderate Effect of Flavonoids on Vascular and Renal Function in Spontaneously Hypertensive Rats by Paredes, María D, Romecín, Paola, Atucha, Noemí M, O'Valle, Francisco, Castillo, Julián, Ortiz, María Clara, García-Estañ, Joaquín

“…Many studies have shown that flavonoids are effective as antihypertensive drugs in arterial hypertension. In the present work, we have analyzed the effects of…”
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Robust In Vitro and In Vivo Immunosuppressive and Anti-inflammatory Properties of Inducible Caspase-9-mediated Apoptotic Mesenchymal Stromal/Stem Cell by Romecín, Paola Alejandra, Vinyoles, Meritxell, López-Millán, Belén, de la Guardia, Rafael Diaz, Atucha, Noemi M, Querol, Sergi, Bueno, Clara, Benitez, Raquel, Gonzalez-Rey, Elena, Delgado, Mario, Menéndez, Pablo

“…Mesenchymal stromal stem/cells (MSC) therapies are clinically used in a wide range of disorders based on their robust HLA-independent immunosuppressive and…”
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Role of homocysteine and folic acid on the altered calcium homeostasis of platelets from rats with biliary cirrhosis by Romecín, Paola, Atucha, Noemí M., Navarro, Esther G., Ortiz, M. Clara, Iyú, David, Rosado, Juan Antonio, García-Estañ, Joaquín

“…Previously, we have found that intracellular calcium homeostasis is altered in platelets from an experimental model of liver cirrhosis, the bile-duct ligated…”
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Bile Acids Do Not Contribute to the Altered Calcium Homeostasis of Platelets from Rats with Biliary Cirrhosis by Romecín, Paola, Navarro, Esther G, Ortiz, M Clara, Iyú, David, García-Estañ, Joaquín, Atucha, Noemí M

“…Previously, we have found that intracellular calcium homeostasis is altered in platelets from an experimental model of liver cirrhosis, the bile-duct ligated…”
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Platelet function and microvesicle generation in patients with hemophilia A by Melero‐Amor, Antonia, Romecín, Paola, Iyú, David, García‐Bernal, David, García‐Navaro, Esther, Moraleda, José M., García‐Estañ, Joaquín, García‐Candel, Faustino, Atucha, Noemí M.

“…Our results do not support any effect of FVIII on platelet function in patients with severe HA treated under the regime of prophylaxis. Our results do not…”
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Corticotropin‐releasing factor (CRF) receptor‐1 is involved in cardiac noradrenergic activity observed during naloxone‐precipitated morphine withdrawal by Martínez‐Laorden, Elena, García‐Carmona, Juan‐Antonio, Baroja‐Mazo, Alberto, Romecín, Paola, Atucha, Noemí M, Milanés, María‐Victoria, Laorden, María‐Luisa

“…Background and Purpose The negative affective states of withdrawal involve the recruitment of brain and peripheral stress circuitry [noradrenergic activity,…”
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A novel and efficient tandem CD19- and CD22-directed CAR for B cell ALL by Zanetti, Samanta Romina, Velasco-Hernandez, Talia, Gutierrez-Agüera, Francisco, Díaz, Víctor M., Romecín, Paola Alejandra, Roca-Ho, Heleia, Sánchez-Martínez, Diego, Tirado, Néstor, Baroni, Matteo Libero, Petazzi, Paolo, Torres-Ruiz, Raúl, Molina, Oscar, Bataller, Alex, Fuster, José Luis, Ballerini, Paola, Juan, Manel, Jeremias, Irmela, Bueno, Clara, Menéndez, Pablo

“…CD19-directed chimeric antigen receptor (CAR) T cells have yielded impressive response rates in refractory/relapse B cell acute lymphoblastic leukemia (B-ALL);…”
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Transcriptional Induction of Periostin by a Sulfatase 2-TGF beta 1-SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma by Chen, Gang, Nakamura, Ikuo, Dhanasekaran, Renumathy, Iguchi, Eriko, Tolosa, Ezequiel J, Romecin, Paola A, Vera, Renzo E, Almada, Luciana L, Miamen, Alexander G, Chaiteerakij, Roongruedee, Zhou, Mengtao, Asiedu, Michael K, Moser, Catherine D, Han, Shaoshan, Hu, Chunling, Banini, Bubu A, Oseini, Abdul M, Chen, Yichun, Fang, Yong, Yang, Dongye, Shaleh, Hassan M, Wang, Shaoqing, Wu, Dehai, Song, Tao, Lee, Ju-Seog, Thorgeirsson, Snorri S, Chevet, Eric, Shah, Vijay H, Fernandez-Zapico, Martin E, Roberts, Lewis R

“…These findings define an important axis controlling angiogenesis in metastatic liver cancers and a mechanistic foundation for rational drug development…”
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ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma by Mensali, Nadia, Köksal, Hakan, Joaquina, Sandy, Wernhoff, Patrik, Casey, Nicholas P., Romecin, Paola, Panisello, Carla, Rodriguez, René, Vimeux, Lene, Juzeniene, Asta, Myhre, Marit R., Fåne, Anne, Ramírez, Carolina Castilla, Maggadottir, Solrun Melkorka, Duru, Adil Doganay, Georgoudaki, Anna-Maria, Grad, Iwona, Maturana, Andrés Daniel, Gaudernack, Gustav, Kvalheim, Gunnar, Carcaboso, Angel M., de Alava, Enrique, Donnadieu, Emmanuel, Bruland, Øyvind S., Menendez, Pablo, Inderberg, Else Marit, Wälchli, Sébastien

“…Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are…”
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The insecticides permethrin and chlorpyrifos show limited genotoxicity and no leukemogenic potential in human and murine hematopoietic stem progenitor cells by Rodriguez-Cortez, Virginia C, Navarrete-Meneses, Maria Pilar, Molina, Oscar, Velasco-Hernandez, Talia, Gonzalez, Jessica, Romecin, Paola, Gutierrez-Aguera, Francisco, Roca-Ho, Heleia, Vinyoles, Meritxell, Kowarz, Eric, Marin, Pedro, Rodriguez-Perales, Sandra, Gomez-Marin, Carlos, Perez-Vera, Patricia, Cortes-Ledesma, Felipe, Bigas, Anna, Terron, Andrea, Bueno, Clara, Menendez, Pablo

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The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoter-looping GLI1-STAT3 transcriptional complex by Carr, Ryan M., Romecin Duran, Paola A., Tolosa, Ezequiel J., Ma, Chenchao, Oseini, Abdul M., Moser, Catherine D., Banini, Bubu A., Huang, Jianbo, Asumda, Faizal, Dhanasekaran, Renumathy, Graham, Rondell P., Toruner, Merih D., Safgren, Stephanie L., Almada, Luciana L., Wang, Shaoqing, Patnaik, Mrinal M., Roberts, Lewis R., Fernandez-Zapico, Martin E.

“…The expression of the extracellular sulfatase SULF2 has been associated with increased hepatocellular carcinoma (HCC) growth and poor patient survival…”
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A rare germline CDKN2A variant (47T>G; p16-L16R) predisposes carriers to pancreatic cancer by reducing cell cycle inhibition by Horn, Isaac P., Marks, David L., Koenig, Amanda N., Hogenson, Tara L., Almada, Luciana L., Goldstein, Lauren E., Romecin Duran, Paola A., Vera, Renzo, Vrabel, Anne M., Cui, Gaofeng, Rabe, Kari G., Bamlet, William R., Mer, Georges, Sicotte, Hugues, Zhang, Cheng, Li, Hu, Petersen, Gloria M., Fernandez-Zapico, Martin E.

“…Germline mutations in CDKN2A, encoding the tumor suppressor p16, are responsible for a large proportion of familial melanoma cases and also increase risk of…”
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The Multi-Kinase Inhibitor EC-70124 Is a Promising Candidate for the Treatment of FLT3-ITD-Positive Acute Myeloid Leukemia by Lopez-Millan, Belen, Costales, Paula, Gutiérrez-Agüera, Francisco, Díaz de la Guardia, Rafael, Roca-Ho, Heleia, Vinyoles, Meritxell, Rubio-Gayarre, Alba, Safi, Rémi, Castaño, Julio, Romecín, Paola Alejandra, Ramírez-Orellana, Manuel, Anguita, Eduardo, Jeremias, Irmela, Zamora, Lurdes, Rodríguez-Manzaneque, Juan Carlos, Bueno, Clara, Morís, Francisco, Menendez, Pablo

“…Acute myeloid leukemia (AML) is the most common acute leukemia in adults. Patients with AML harboring a constitutively active internal tandem duplication…”
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The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP) by Velasco, Pablo, Bautista, Francisco, Rubio, Alba, Aguilar, Yurena, Rives, Susana, Dapena, Jose L., Pérez, Antonio, Ramirez, Manuel, Saiz-Ladera, Cristina, Izquierdo, Elisa, Escudero, Adela, Camós, Mireia, Vega-García, Nerea, Ortega, Margarita, Hidalgo-Gómez, Gloria, Palacio, Carlos, Menéndez, Pablo, Bueno, Clara, Montero, Joan, Romecín, Paola A., Zazo, Santiago, Alvarez, Federico, Parras, Juan, Ortega-Sabater, Carmen, Chulián, Salvador, Rosa, María, Cirillo, Davide, García, Elena, García, Jorge, Manzano-Muñoz, Albert, Minguela, Alfredo, Fuster, Jose L.

“…Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with survival rates exceeding 85%. However, 15% of patients will relapse; consequently,…”
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Activation of the Transcription Factor GLI1 by WNT Signaling Underlies the Role of SULFATASE 2 as a Regulator of Tissue Regeneration by Nakamura, Ikuo, Fernandez-Barrena, Maite G., Ortiz-Ruiz, Maria C., Almada, Luciana L., Hu, Chunling, Elsawa, Sherine F., Mills, Lisa D., Romecin, Paola A., Gulaid, Kadra H., Moser, Catherine D., Han, Jing-Jing, Vrabel, Anne, Hanse, Eric A., Akogyeram, Nicholas A., Albrecht, Jeffrey H., Monga, Satdarshan P.S., Sanderson, Schuyler O., Prieto, Jesus, Roberts, Lewis R., Fernandez-Zapico, Martin E.

“…Tissue regeneration requires the activation of a set of specific growth signaling pathways. The identity of these cascades and their biological roles are…”
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