RNase E Processing of Essential Cell Division Genes mRNA in Escherichia Coli

The ratio of the FtsZ to FtsA proteins determines the correct initiation of cell division in Escherichia coli. The genes for these proteins are contiguous on the chromosome. Although both genes are transcribed from common promoters, the presence of ftsZ-specific promoters, along with differences in...

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Bibliographic Details
Published in:	Nucleic acids research Vol. 24; no. 15; pp. 3065 - 3070
Main Authors:	Cam, Kaymeuang, Rome, Gilles, Krisch, Henry M., Bouché, Jean-Pierre
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01-08-1996
Subjects:	Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Base Sequence Cell Division - genetics Cytoskeletal Proteins Endoribonucleases - metabolism Escherichia coli Escherichia coli - cytology Escherichia coli - genetics Escherichia coli Proteins Gene Expression Regulation, Bacterial Molecular Sequence Data RNA Processing, Post-Transcriptional RNA, Bacterial - metabolism RNA, Messenger - metabolism
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Summary:	The ratio of the FtsZ to FtsA proteins determines the correct initiation of cell division in Escherichia coli. The genes for these proteins are contiguous on the chromosome. Although both genes are transcribed from common promoters, the presence of ftsZ-specific promoters, along with differences in the efficiency of translation of their respective mRNAs, contribute to the increased relative expression of ftsZ. We report here that the polycistronic ftsA-ftsZ transcripts are cleaved by RNase E and that this cleavage affects the decay of ftsA and ftsZ mRNA. As a consequence of the cleavage, RNase E also contributes to the differential expression of the two genes.
Bibliography:	ark:/67375/HXZ-C6QJ7JCJ-9 To whom correspondence should be addressed istex:A52074A2FDAFC80988A4DDF881B443C32CFB2B5E ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0305-1048 1362-4962 1362-4962
DOI:	10.1093/nar/24.15.3065