Search Results - "Romdhane, Lilia"

Ethnic and functional differentiation of copy number polymorphisms in Tunisian and HapMap population unveils insights on genome organizational plasticity by Romdhane, Lilia, Kefi, Sameh, Mezzi, Nessrine, Abassi, Najla, Jmel, Haifa, Romdhane, Safa, Shan, Jingxuan, Chouchane, Lotfi, Abdelhak, Sonia

“…Admixture mapping has been useful in identifying genetic variations linked to phenotypes, adaptation and diseases. Copy number variations (CNVs) represents…”
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Founder mutations in Tunisia: implications for diagnosis in North Africa and Middle East by Romdhane, Lilia, Kefi, Rym, Azaiez, Hela, Ben Halim, Nizar, Dellagi, Koussay, Abdelhak, Sonia

“…Tunisia is a North African country of 10 million inhabitants. The native background population is Berber. However, throughout its history, Tunisia has been the…”
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Germline copy number variations in BRCA1/2 negative families: Role in the molecular etiology of hereditary breast cancer in Tunisia by Boujemaa, Maroua, Hamdi, Yosr, Mejri, Nesrine, Romdhane, Lilia, Ghedira, Kais, Bouaziz, Hanen, El Benna, Houda, Labidi, Soumaya, Dallali, Hamza, Jaidane, Olfa, Ben Nasr, Sonia, Haddaoui, Abderrazek, Rahal, Khaled, Abdelhak, Sonia, Boussen, Hamouda, Boubaker, Mohamed Samir

“…Hereditary breast cancer accounts for 5-10% of all breast cancer cases. So far, known genetic risk factors account for only 50% of the breast cancer genetic…”
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Pharmacogenetic landscape of Metabolic Syndrome components drug response in Tunisia and comparison with worldwide populations by Jmel, Haifa, Romdhane, Lilia, Ben Halima, Yosra, Hechmi, Meriem, Naouali, Chokri, Dallali, Hamza, Hamdi, Yosr, Shan, Jingxuan, Abid, Abdelmajid, Jamoussi, Henda, Trabelsi, Sameh, Chouchane, Lotfi, Luiselli, Donata, Abdelhak, Sonia, Kefi, Rym

“…Genetic variation is an important determinant affecting either drug response or susceptibility to adverse drug reactions. Several studies have highlighted the…”
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A genome wide SNP genotyping study in the Tunisian population: specific reporting on a subset of common breast cancer risk loci by Hamdi, Yosr, Ben Rekaya, Mariem, Jingxuan, Shan, Nagara, Majdi, Messaoud, Olfa, Benammar Elgaaied, Amel, Mrad, Ridha, Chouchane, Lotfi, Boubaker, Mohamed Samir, Abdelhak, Sonia, Boussen, Hamouda, Romdhane, Lilia

“…Breast cancer is the most common cancer in women worldwide. Around 50% of breast cancer familial risk has been so far explained by known susceptibility alleles…”
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Corrigendum: Current phenotypic and genetic spectrum of syndromic deafness in Tunisia: paving the way for precision auditory health by Mkaouar, Rahma, Riahi, Zied, Marrakchi, Jihene, Mezzi, Nessrine, Romdhane, Lilia, Boujemaa, Maroua, Dallali, Hamza, Sayeb, Marwa, Lahbib, Saida, Jaouadi, Hajer, Boudabbous, Hela, Zekri, Lotfi, Chargui, Mariem, Messaoud, Olfa, Elyounsi, Meriem, Kraoua, Ichraf, Zaouak, Anissa, Turki, Ilhem, Mokni, Mourad, Boucher, Sophie, Petit, Christine, Giraudet, Fabrice, Mbarek, Chiraz, Besbes, Ghazi, Halayem, Soumeyya, Zainine, Rim, Turki, Hamida, Tounsi, Amel, Bonnet, Crystel, Mrad, Ridha, Abdelhak, Sonia, Trabelsi, Mediha, Charfeddine, Cherine

“…[This corrects the article DOI: 10.3389/fgene.2024.1384094.]…”
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A map of copy number variations in the Tunisian population: a valuable tool for medical genomics in North Africa by Romdhane, Lilia, Mezzi, Nessrine, Dallali, Hamza, Messaoud, Olfa, Shan, Jingxuan, Fakhro, Khalid A., Kefi, Rym, Chouchane, Lotfi, Abdelhak, Sonia

“…Copy number variation (CNV) is considered as the most frequent type of structural variation in the human genome. Some CNVs can act on human phenotype…”
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Current phenotypic and genetic spectrum of syndromic deafness in Tunisia: paving the way for precision auditory health by Mkaouar, Rahma, Riahi, Zied, Marrakchi, Jihene, Mezzi, Nessrine, Romdhane, Lilia, Boujemaa, Maroua, Dallali, Hamza, Sayeb, Marwa, Lahbib, Saida, Jaouadi, Hager, Boudabbous, Hela, Zekri, Lotfi, Chargui, Mariem, Messaoud, Olfa, Elyounsi, Meriem, Kraoua, Ichraf, Zaouak, Anissa, Turki, Ilhem, Mokni, Mourad, Boucher, Sophie, Petit, Christine, Giraudet, Fabrice, Mbarek, Chiraz, Besbes, Ghazi, Halayem, Soumeyya, Zainine, Rim, Turki, Hamida, Tounsi, Amel, Bonnet, Crystel, Mrad, Ridha, Abdelhak, Sonia, Trabelsi, Mediha, Charfeddine, Cherine

“…Hearing impairment (HI) is a prevalent neurosensory condition globally, impacting 5% of the population, with over 50% of congenital cases attributed to genetic…”
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Cytogenetic and molecular diagnosis of Fanconi anemia revealed two hidden phenotypes: Disorder of sex development and cerebro‐oculo‐facio‐skeletal syndrome by Ben Haj Ali, Abir, Amouri, Ahlem, Sayeb, Marwa, Makni, Saloua, Hammami, Wajih, Naouali, Chokri, Dallali, Hamza, Romdhane, Lilia, Bashamboo, Anu, McElreavey, Kenneth, Abdelhak, Sonia, Messaoud, Olfa

“…Background Several studies have shown a high rate of consanguinity and endogamy in North African populations. As a result, the frequency of autosomal recessive…”
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Consanguinity and Inbreeding in Health and Disease in North African Populations by Romdhane, Lilia, Mezzi, Nessrine, Hamdi, Yosr, El-Kamah, Ghada, Barakat, Abdelhamid, Abdelhak, Sonia

“…North Africa is defined as the geographical region separated from the rest of the continent by the Sahara and from Europe by the Mediterranean Sea. The main…”
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Consanguinity and rare disease in North Africa: Current situation and perspectives by Romdhane, Lilia, Abdelhak, Sonia

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Comorbidity of bathing suit ichthyosis and limb-girdle muscular dystrophy type 2 A in a Tunisian patient revealed by Whole Exome Sequencing by Mezzi, Nessrine, Zaouak, Anissa, Mkaouar, Rahma, Kacem, Imen, Gouider, Riadh, Fenniche, Samy, Mrad, Ridha, Abdelhak, Sonia, Romdhane, Lilia

“…Elevated rates of consanguinity and inbreeding are responsible for the high prevalence of recessively inherited diseases among inbred populations including…”
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The morbid cutaneous anatomy of the human genome revealed by a bioinformatic approach by Romdhane, Lilia, Bouhamed, Heni, Ghedira, Kais, Ben Hamda, Cherif, Louhichi, Amel, Jmel, Haifa, Romdhane, Safa, Charfeddine, Chérine, Mokni, Mourad, Abdelhak, Sonia, Rebai, Ahmed

“…Computational approaches have been developed to prioritize candidate genes in disease gene identification. They are based on different pieces of evidences…”
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Genetic diversity and functional effect of common polymorphisms in genes involved in the first heterodimeric complex of the Nucleotide Excision Repair pathway by Hamdi, Yosr, Jerbi, Manel, Romdhane, Lilia, Ben Rekaya, Mariem, El Benna, Houda, Chouchane, Lotfi, Boubaker, Mohamed Samir, Abdelhak, Sonia, Yacoub-Youssef, Houda

“…•Twenty regulatory SNPs contributed to the inter-ethnic diversity of the NER-complex.•Common regulatory variants of DDB1 seem to be associated with skin…”
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Human OMICs and Computational Biology Research in Africa: Current Challenges and Prospects by Hamdi, Yosr, Zass, Lyndon, Othman, Houcemeddine, Radouani, Fouzia, Allali, Imane, Hanachi, Mariem, Okeke, Chiamaka Jessica, Chaouch, Melek, Tendwa, Maureen Bilinga, Samtal, Chaimae, Mohamed Sallam, Reem, Alsayed, Nihad, Turkson, Michael, Ahmed, Samah, Benkahla, Alia, Romdhane, Lilia, Souiai, Oussema, Tastan Bishop, Özlem, Ghedira, Kais, Mohamed Fadlelmola, Faisal, Mulder, Nicola, Kamal Kassim, Samar

“…Following the publication of the first human genome, OMICs research, including genomics, transcriptomics, proteomics, and metagenomics, has been on the rise…”
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A review of clinical pharmacogenetics Studies in African populations by Radouani, Fouzia, Zass, Lyndon, Hamdi, Yosr, Rocha, Jorge da, Sallam, Reem, Abdelhak, Sonia, Ahmed, Samah, Azzouzi, Maryame, Benamri, Ichrak, Benkahla, Alia, Bouhaouala-Zahar, Balkiss, Chaouch, Melek, Jmel, Haifa, Kefi, Rym, Ksouri, Ayoub, Kumuthini, Judit, Masilela, Phumlani, Masimirembwa, Collen, Othman, Houcemeddine, Panji, Sumir, Romdhane, Lilia, Samtal, Chaimae, Sibira, Rania, Ghedira, Kais, Fadlelmola, Faisal, Kassim, Samar Kamal, Mulder, Nicola

“…Effective interventions and treatments for complex diseases have been implemented globally, however, coverage in Africa has been comparatively lower due to…”
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Mediterranean Founder Mutation Database (MFMD): Taking Advantage from Founder Mutations in Genetics Diagnosis, Genetic Diversity and Migration History of the Mediterranean Population by Charoute, Hicham, Bakhchane, Amina, Benrahma, Houda, Romdhane, Lilia, Gabi, Khalid, Rouba, Hassan, Fakiri, Malika, Abdelhak, Sonia, Lenaers, Guy, Barakat, Abdelhamid

“…ABSTRACT The Mediterranean basin has been the theater of migration crossroads followed by settlement of several societies and cultures in prehistoric and…”
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Spectrum of Genetic Diseases in Tunisia: Current Situation and Main Milestones Achieved by Mezzi, Nessrine, Messaoud, Olfa, Mkaouar, Rahma, Zitouna, Nadia, Romdhane, Safa, Abdessalem, Ghaith, Charfeddine, Cherine, Maazoul, Faouzi, Ouerteni, Ines, Hamdi, Yosr, Zaouak, Anissa, Mrad, Ridha, Abdelhak, Sonia, Romdhane, Lilia

“…Genetic diseases in Tunisia are a real public health problem given their chronicity and the lack of knowledge concerning their prevalence and etiology, and the…”
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Consanguinité et son impact sur la santé et la dynamique du génome : Un exemple de la Tunisie by Mezzi, Nessrine, Abassi, Najla, Fatnassi, Faten, Abdelhak, Sonia, Romdhane, Lilia

“…Le spectre des maladies génétiques en Tunisie résulte de l'effet fondateur, de la dérive génétique, de la pression de sélection, et de la consanguinité…”
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Update of the spectrum of GJB2 gene mutations in Tunisian families with autosomal recessive nonsyndromic hearing loss by Riahi, Zied, Hammami, Hassen, Ouragini, Houyem, Messai, Habib, Zainine, Rim, Bouyacoub, Yosra, Romdhane, Lilia, Essaid, Donia, Kefi, Rym, Rhimi, Mohsen, Bedoui, Monia, Dhaouadi, Afef, Feldmann, Delphine, Jonard, Laurence, Besbes, Ghazi, Abdelhak, Sonia

“…Hearing loss is the most frequent sensory disorder. It affects 3 in 1000 newborns. It is genetically heterogeneous with 60 causally-related genes identified to…”
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