Search Results - "Romany, Isabel Arrillaga"

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma by Cloughesy, Timothy F., Mochizuki, Aaron Y., Orpilla, Joey R., Hugo, Willy, Lee, Alexander H., Davidson, Tom B., Wang, Anthony C., Ellingson, Benjamin M., Rytlewski, Julie A., Sanders, Catherine M., Kawaguchi, Eric S., Du, Lin, Li, Gang, Yong, William H., Gaffey, Sarah C., Cohen, Adam L., Mellinghoff, Ingo K., Lee, Eudocia Q., Reardon, David A., O’Brien, Barbara J., Butowski, Nicholas A., Nghiemphu, Phioanh L., Clarke, Jennifer L., Arrillaga-Romany, Isabel C., Colman, Howard, Kaley, Thomas J., de Groot, John F., Liau, Linda M., Wen, Patrick Y., Prins, Robert M.

“…Glioblastoma is the most common primary malignant brain tumor in adults and is associated with poor survival. The Ivy Foundation Early Phase Clinical Trials…”
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Case 6-2021: A 65-Year-Old Man with Eye Pain and Decreased Vision by Bouffard, Marc A, Chwalisz, Bart K, Romero, Javier M, Arrillaga-Romany, Isabel C, Massoth, Lucas R

“…A 65-year-old man with Waldenström’s macroglobulinemia was evaluated because of an 8-day history of bilateral eye pain and decreased vision. He had decreased…”
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Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate by Andronesi, Ovidiu C., Arrillaga-Romany, Isabel C., Ly, K. Ina, Bogner, Wolfgang, Ratai, Eva M., Reitz, Kara, Iafrate, A. John, Dietrich, Jorg, Gerstner, Elizabeth R., Chi, Andrew S., Rosen, Bruce R., Wen, Patrick Y., Cahill, Daniel P., Batchelor, Tracy T.

“…Inhibitors of the mutant isocitrate dehydrogenase 1 ( IDH1 ) entered recently in clinical trials for glioma treatment. Mutant IDH1 produces high levels of…”
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Clinical, radiological and genomic features and targeted therapy in BRAF V600E mutant adult glioblastoma by Lim-Fat, Mary Jane, Song, Kun Wei, Iorgulescu, J. Bryan, Andersen, Brian M., Forst, Deborah A., Jordan, Justin T., Gerstner, Elizabeth R., Reardon, David A., Wen, Patrick Y., Arrillaga-Romany, Isabel

“…Purpose Although uncommon, detection of BRAF V600E mutations in adult patients with glioblastoma has become increasingly relevant given the widespread…”
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Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas by Brastianos, Priscilla K., Kim, Albert E., Giobbie-Hurder, Anita, Lee, Eudocia Quant, Wang, Nancy, Eichler, April F., Chukwueke, Ugonma, Forst, Deborah A., Arrillaga-Romany, Isabel C., Dietrich, Jorg, Corbin, Zachary, Moliterno, Jennifer, Baehring, Joachim, White, Michael, Lou, Kevin W., Larson, Juliana, de Sauvage, Magali A., Evancic, Kathryn, Mora, Joana, Nayyar, Naema, Loeffler, Jay, Oh, Kevin, Shih, Helen A., Curry, William T., Cahill, Daniel P., Barker, Fred G., Gerstner, Elizabeth R., Santagata, Sandro

“…High-grade meningiomas are associated with neuro-cognitive morbidity and have limited treatments. High-grade meningiomas harbor an immunosuppressive tumor…”
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Neurologic Complications of Systemic Anticancer Therapy by Ly, Kien-Ninh Ina, MD, Arrillaga-Romany, Isabel C., MD, PhD

“…Neurologic complications of systemic cancer therapy encompass a range of symptoms that can affect the central nervous system (CNS), peripheral nervous system…”
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Imaging findings in cancer therapy-associated neurotoxicity by Arrillaga-Romany, Isabel C, Dietrich, Jorg

“…Cancer therapy can cause several neurotoxic syndromes that are associated with distinct findings on cranial imaging. With the use of more aggressive and…”
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Anti-CD19 CAR T Cells in CNS Diffuse Large-B-Cell Lymphoma by Abramson, Jeremy S, McGree, Brianne, Noyes, Sarah, Plummer, Sean, Wong, Curtis, Chen, Yi-Bin, Palmer, Edwin, Albertson, Tina, Ferry, Judith A, Arrillaga-Romany, Isabel C

“…In this case, a woman with refractory diffuse large-B-cell lymphoma had a CNS recurrence that responded completely to anti-CD19 CAR T-cell therapy. After…”
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Clinical presentation, management, and biomarkers of neurotoxicity after adoptive immunotherapy with CAR T cells by Karschnia, Philipp, Jordan, Justin T., Forst, Deborah A., Arrillaga-Romany, Isabel C., Batchelor, Tracy T., Baehring, Joachim M., Clement, Nathan F., Gonzalez Castro, L. Nicolas, Herlopian, Aline, Maus, Marcela V., Schwaiblmair, Michaela H., Soumerai, Jacob D., Takvorian, Ronald W., Hochberg, Ephraim P., Barnes, Jeffrey A., Abramson, Jeremy S., Frigault, Matthew J., Dietrich, Jorg

“…Chimeric antigen receptor (CAR) T cells have emerged as a promising class of cell-based immunotherapy in refractory malignancies. Neurotoxicity represents a…”
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A phase 2 study of the first imipridone ONC201, a selective DRD2 antagonist for oncology, administered every three weeks in recurrent glioblastoma by Arrillaga-Romany, Isabel, Chi, Andrew S, Allen, Joshua E, Oster, Wolfgang, Wen, Patrick Y, Batchelor, Tracy T

“…ONC201 is an oral, small molecule selective antagonist of the G protein-coupled receptor DRD2 that causes p53-independent apoptosis in tumor cells via…”
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Clinical Reasoning: Assessing New Neurologic Deficits in Patients With Hematologic Malignancy on Bruton Tyrosine Kinase Inhibitor Therapy by Nelson, Thomas A, Murthy, Naina K, Martinez-Lage Alvarez, Maria, Abramson, Jeremy, Branagan, Andrew R, Ji, Yongli, Chen, Yi-Bin A, Letourneau, Alyssa R, Nahed, Brian V, Arrillaga-Romany, Isabel C, Wang, Nancy, Dietrich, Jorg

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TERT and DNMT1 expression predict sensitivity to decitabine in gliomas by Park, Jong-Whi, Sahm, Felix, Steffl, Bianca, Arrillaga-Romany, Isabel, Cahill, Daniel, Monje, Michelle, Herold-Mende, Christel, Wick, Wolfgang, Turcan, Şevin

“…Abstract Background Decitabine (DAC) is an FDA-approved DNA methyltransferase (DNMT) inhibitor that is used in the treatment of patients with myelodysplastic…”
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Bavituximab Decreases Immunosuppressive Myeloid-Derived Suppressor Cells in Newly Diagnosed Glioblastoma Patients by Ly, K Ina, Richardson, Leland G, Liu, Mofei, Muzikansky, Alona, Cardona, Jonathan, Lou, Kevin, Beers, Andrew L, Chang, Ken, Brown, James M, Ma, Xiaoyue, Reardon, David A, Arrillaga-Romany, Isabel C, Forst, Deborah A, Jordan, Justin T, Lee, Eudocia Q, Dietrich, Jorg, Nayak, Lakshmi, Wen, Patrick Y, Chukwueke, Ugonma, Giobbie-Hurder, Anita, Choi, Bryan D, Batchelor, Tracy T, Kalpathy-Cramer, Jayashree, Curry, William T, Gerstner, Elizabeth R

“…We evaluated the efficacy of bavituximab-a mAb with anti-angiogenic and immunomodulatory properties-in newly diagnosed patients with glioblastoma (GBM) who…”
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Accelerated progression of IDH mutant glioma after first recurrence by Miller, Julie J, Loebel, Franziska, Juratli, Tareq A, Tummala, Shilpa S, Williams, Erik A, Batchelor, Tracy T, Arrillaga-Romany, Isabel, Cahill, Daniel P

“…Isocitrate dehydrogenase (IDH) mutant gliomas are a distinct subtype, reflected in the World Health Organization (WHO) 2016 revised diagnostic criteria. To…”
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Validation of postoperative residual contrast-enhancing tumor volume as an independent prognostic factor for overall survival in newly diagnosed glioblastoma by Ellingson, Benjamin M, Abrey, Lauren E, Nelson, Sarah J, Kaufmann, Timothy J, Garcia, Josep, Chinot, Olivier, Saran, Frank, Nishikawa, Ryo, Henriksson, Roger, Mason, Warren P, Wick, Wolfgang, Butowski, Nicholas, Ligon, Keith L, Gerstner, Elizabeth R, Colman, Howard, de Groot, John, Chang, Susan, Mellinghoff, Ingo, Young, Robert J, Alexander, Brian M, Colen, Rivka, Taylor, Jennie W, Arrillaga-Romany, Isabel, Mehta, Arnav, Huang, Raymond Y, Pope, Whitney B, Reardon, David, Batchelor, Tracy, Prados, Michael, Galanis, Evanthia, Wen, Patrick Y, Cloughesy, Timothy F

“…In the current study, we pooled imaging data in newly diagnosed glioblastoma (GBM) patients from international multicenter clinical trials, single institution…”
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Neurotoxicity and management of primary and secondary central nervous system lymphoma after adoptive immunotherapy with CD19-directed chimeric antigen receptor T-cells by Karschnia, Philipp, Arrillaga-Romany, Isabel C, Eichler, April, Forst, Deborah A, Gerstner, Elizabeth, Jordan, Justin T, Ly, Ina, Plotkin, Scott R, Wang, Nancy, Martinez-Lage, Maria, Winter, Sebastian F, Tonn, Joerg-Christian, Rejeski, Kai, von Baumgarten, Louisa, Cahill, Daniel P, Nahed, Brian V, Shankar, Ganesh M, Abramson, Jeremy S, Barnes, Jeffrey A, El-Jawahri, Areej, Hochberg, Ephraim P, Johnson, P Connor, Soumerai, Jacob D, Takvorian, Ronald W, Chen, Yi-Bin, Frigault, Matthew J, Dietrich, Jorg

“…Abstract Background Chimeric antigen receptor (CAR) T-cells targeting CD19 have been established as a leading engineered T-cell therapy for B-cell lymphomas;…”
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Long-lasting alteration in mesocorticolimbic structures after repeated social defeat stress in rats: time course of µ-opioid receptor mRNA and FosB/ΔFosB immunoreactivity by Nikulina, Ella M., Arrillaga-Romany, Isabel, Miczek, Klaus A., Hammer Jr, Ronald P.

“…Social defeat stress is a salient stressor that induces neuroadaptive changes in the mesocorticolimbic dopaminergic system. Substantial evidence indicates that…”
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Modulatory Effects of Modafinil on Neural Circuits Regulating Emotion and Cognition by RASETTI, Roberta, MATTAY, Venkata S, WEINBERGER, Daniel R, STANKEVICH, Beth, SKJEI, Kelsey, BLASI, Giuseppe, SAMBATARO, Fabio, ARRILLAGA-ROMANY, Isabel C, GOLDBERG, Terry E, CALLICOTT, Joseph H, APUD, José A

“…Modafinil differs from other arousal-enhancing agents in chemical structure, neurochemical profile, and behavioral effects. Most functional neuroimaging…”
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Temozolomide therapy for aggressive functioning pituitary adenomas refractory to surgery and radiation: a case series by Jordan, Justin T, Miller, Julie J, Cushing, Tucker, Seijo, Marlon, Batchelor, Tracy T, Arrillaga-Romany, Isabel C, Shih, Helen A, Nachtigall, Lisa B, Loeffler, Jay S, Dietrich, Jorg

“…Abstract Background Treatment of aggressive pituitary adenomas typically involves a multimodality approach based on histopathological features and may include…”
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Neurologic Complications of Cancer Drug Therapies by Lee, Eudocia Quant, Arrillaga-Romany, Isabel C, Wen, Patrick Y

“…PURPOSE OF REVIEW:The purpose of this article is to review neurologic complications associated with systemic anticancer therapies. RECENT FINDINGS:Although…”
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