Search Results - "Romanowski, G"

Cyclopentenylcytosine (CPE-C): In Vitro and In Vivo Evaluation as an Antiviral against Adenoviral Ocular Infections by Romanowski, Eric G, Yates, Kathleen A, Gordon, Y Jerold

“…Adenoviruses are the major cause of ocular viral infections worldwide. Currently, there is no approved antiviral treatment for these eye infections…”
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Reactive silver inks for antiviral, repellent medical textiles with ultrasonic bleach washing durability compared to silver nanoparticles by Galante, Anthony J, Pilsbury, Brady C, Yates, Kathleen A, LeMieux, Melbs, Bain, Daniel J, Shanks, Robert M Q, Romanowski, Eric G, Leu, Paul W

“…Medical textiles are subject to particularly harsh disinfection procedures in healthcare settings where exposure risks are high. This work demonstrates a…”
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Topical Astodrimer Sodium, a Non-Toxic Polyanionic Dendrimer, Demonstrates Antiviral Activity in an Experimental Ocular Adenovirus Infection Model by Romanowski, Eric G, Yates, Kathleen A, Paull, Jeremy R A, Heery, Graham P, Shanks, Robert M Q

“…There is no approved antiviral therapy for adenovirus (HAdV) ocular infections. Astodrimer sodium (SPL7013) is a polyanionic dendrimer with antiviral activity…”
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An Eye to a Kill: Using Predatory Bacteria to Control Gram-Negative Pathogens Associated with Ocular Infections by Shanks, Robert M Q, Davra, Viral R, Romanowski, Eric G, Brothers, Kimberly M, Stella, Nicholas A, Godboley, Dipti, Kadouri, Daniel E

“…Ocular infections are a leading cause of vision loss. It has been previously suggested that predatory prokaryotes might be used as live antibiotics to control…”
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The In Vitro Evaluation of Povidone-Iodine Against Multiple Ocular Adenoviral Types by Yates, Kathleen A, Shanks, Robert M Q, Kowalski, Regis P, Romanowski, Eric G

“…Povidone-iodine (P-I) is being touted as a topical antiviral treatment for eye infections caused by adenovirus (Ad). This study evaluated the in vitro…”
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Clearance of Gram-Negative Bacterial Pathogens from the Ocular Surface by Predatory Bacteria by Romanowski, Eric G, Gupta, Shilpi, Pericleous, Androulla, Kadouri, Daniel E, Shanks, Robert M Q

“…It was previously demonstrated that predatory bacteria are able to efficiently eliminate Gram-negative pathogens including antibiotic-resistant and…”
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The Efficacy of Topical Cefiderocol Treatment of Experimental Extensively Drug-Resistant Pseudomonas aeruginosa Keratitis Is Dependent upon the State of the Corneal Epithelium by Romanowski, Eric G, Mandell, Jonathan B, Jhanji, Vishal, Shanks, Robert M Q

“…An overlooked factor in the efficacy of topical antibiotics to treat bacterial keratitis is the state of the corneal epithelium. Recently, we evaluated topical…”
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Gatifloxacin and moxifloxacin: an in vitro susceptibility comparison to levofloxacin, ciprofloxacin, and ofloxacin using bacterial keratitis isolates by Kowalski, Regis P., Dhaliwal, Deepinder K., Karenchak, Lisa M., Romanowski, Eric G., Mah, Francis S., Ritterband, David C., Gordon, Y.Jerold

“…We compared the in vitro susceptibility patterns and the minimum inhibitory concentrations (MICs) of gatifloxacin (GAT) and moxifloxacin (MOX)…”
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Anti-Infective Treatment and Resistance Is Rarely Problematic with Eye Infections by Kowalski, Regis P, Nayyar, Shannon V, Romanowski, Eric G, Jhanji, Vishal

“…The treatment of eye infections is very different than treating other body infections that require systemic anti-infectives. Endophthalmitis, keratitis,…”
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A Review of Antimicrobial Peptides and Their Therapeutic Potential as Anti-Infective Drugs by Gordon, Y. Jerold, Romanowski, Eric G., McDermott, Alison M.

“…Purpose: Antimicrobial peptides (AMPs) are an essential part of innate immunity that evolved in most living organisms over 2.6 billion years to combat…”
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Human Cathelicidin (LL-37), a Multifunctional Peptide, is Expressed by Ocular Surface Epithelia and has Potent Antibacterial and Antiviral Activity by Gordon, Y. Jerold, Huang, Ling C., Romanowski, Eric G., Yates, Kathleen A., Proske, Rita J., McDermott, Alison M.

“…Purpose: This study determined whether LL-37 (cathelicidin) is expressed by conjunctival and corneal epithelia as part of ocular host defense. The…”
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Fourth generation fluoroquinolones: new weapons in the arsenal of ophthalmic antibiotics by Mather, Rookaya, Karenchak, Lisa M, Romanowski, Eric G, Kowalski, Regis P

“…PURPOSE: Fourth generation fluoroquinolones (FQs) will soon be introduced to ophthalmology. In this in vitro study, differences in the susceptibility patterns…”
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Extending the use of biologics to mucous membranes by attachment of a binding domain by Shanks, Robert M. Q., Romanowski, Eric G., Romanowski, John E., Davoli, Katherine, McNamara, Nancy A., Klarlund, Jes K.

“…Biologics are almost exclusively administered systemically, but localized delivery is preferable as it minimizes off-target exposure and allows more aggressive…”
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Filociclovir Is an Active Antiviral Agent against Ocular Adenovirus Isolates In Vitro and in the Ad5/NZW Rabbit Ocular Model by Romanowski, Eric G, Hussein, Islam T M, Cardinale, Steven C, Butler, Michelle M, Morin, Lucas R, Bowlin, Terry L, Yates, Kathleen A, Shanks, Robert M Q, Kowalski, Regis P

“…Presently, there is no FDA- or EMA-approved antiviral for the treatment of human adenovirus (HAdV) ocular infections. This study determined the antiviral…”
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A rise in the frequency of lasR mutant Pseudomonas aeruginosa among keratitis isolates between 1993 and 2021 by Shanks, Robert M Q, Atta, Sarah, Stella, Nicholas A, Sundar-Raj, Chollapadi V, Romanowski, John E, Grewal, Arman S, Shanks, Hazel Q, Mumper, Sonya M, Dhaliwal, Deepinder K, Mammen, Alex, Callaghan, Jake D, Calvario, Rachel C, Romanowski, Eric G, Kowalski, Regis P, Zegans, Michael E, Jhanji, Vishal

“…causes vision threatening keratitis. The transcription factor regulates virulence factors in response to the quorum sensing molecule…”
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Speciation and Antibiotic Susceptibilities of Coagulase Negative Staphylococci Isolated from Ocular Infections by Romanowski, John E., Nayyar, Shannon V., Romanowski, Eric G., Jhanji, Vishal, Shanks, Robert M. Q., Kowalski, Regis P.

“…Coagulase-negative staphylococci (CoNS) are frequently occurring ocular opportunistic pathogens that are not easily identifiable to the species level. The goal…”
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Ranpirnase (OKG-0301), a Novel Ribonuclease, Demonstrates Antiviral Activity against Adenovirus in the Ad5/NZW Rabbit Ocular Replication Model by Romanowski, Eric G, Yates, Kathleen A, Daniels, Eric J, Strem, Brian M, Romanowski, John E, Kowalski, Regis P

“…Adenovirus ocular infections are common ocular viral infections seen worldwide, for which there is no approved antiviral therapy available. Ranpirnase is a…”
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Antibiotics Used in Empiric Treatment of Ocular Infections Trigger the Bacterial Rcs Stress Response System Independent of Antibiotic Susceptibility by Harshaw, Nathaniel S, Stella, Nicholas A, Lehner, Kara M, Romanowski, Eric G, Kowalski, Regis P, Shanks, Robert M Q

“…The Rcs phosphorelay is a bacterial stress response system that responds to envelope stresses and in turn controls several virulence-associated pathways,…”
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Evaluation of polyhexamethylene biguanide (PHMB) as a disinfectant for adenovirus by Romanowski, Eric G, Yates, Kathleen A, O'Connor, Katherine E, Mah, Francis S, Shanks, Robert M Q, Kowalski, Regis P

“…Swimming pools can be a vector for transmission of adenovirus ocular infections. Polyhexamethylene biguanide (PHMB) is a disinfectant used in swimming pools…”
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The In Vitro and In Vivo Evaluation of ddC as a Topical Antiviral for Ocular Adenovirus Infections by Romanowski, Eric G, Yates, Kathleen A, Gordon, Y. Jerold

“…To evaluate the antiviral activity of 2', 3'-dideoxycytidine (ddC) in vitro against a panel of ocular adenovirus serotypes and in vivo in the ocular Ad5/NZW…”
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