Search Results - "Romanovsky, Andrej A"

Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system by Romanovsky, Andrej A

“…While summarizing the current understanding of how body temperature (T(b)) is regulated, this review discusses the recent progress in the following areas:…”
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Neural circuitry engaged by prostaglandins during the sickness syndrome by Saper, Clifford B, Romanovsky, Andrej A, Scammell, Thomas E

“…Acute exposure to a variety of pathogens or inflammatory insults leads to a well-characterized set of responses in the CNS, aimed at promoting the clearance of…”
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Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis by Garami, Andras, Shimansky, Yury P., Rumbus, Zoltan, Vizin, Robson C.L., Farkas, Nelli, Hegyi, Judit, Szakacs, Zsolt, Solymar, Margit, Csenkey, Alexandra, Chiche, Dan A., Kapil, Ram, Kyle, Donald J., Van Horn, Wade D., Hegyi, Peter, Romanovsky, Andrej A.

“…Antagonists of the transient receptor potential vanilloid-1 (TRPV1) channel alter body temperature (Tb) in laboratory animals and humans: most cause…”
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Fever and hypothermia in systemic inflammation by Garami, Andras, Steiner, Alexandre A, Romanovsky, Andrej A

“…Systemic inflammation-associated syndromes (e.g., sepsis and septic shock) often have high mortality and remain a challenge in emergency medicine. Systemic…”
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Body Temperature Measurements for Metabolic Phenotyping in Mice by Meyer, Carola W, Ootsuka, Youichirou, Romanovsky, Andrej A

“…Rectal probing is subject to procedural bias. This method is suitable for first-line phenotyping, provided probe depth and measurement duration are…”
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Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes by Rance, Naomi E, Dacks, Penny A, Mittelman-Smith, Melinda A, Romanovsky, Andrej A, Krajewski-Hall, Sally J

“…Highlights • We review the physiology of flushes and CNS heat-defense pathways. • Hypothalamic KNDy neurons are markedly altered in postmenopausal women. •…”
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An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways by Deuis, Jennifer R., Zimmermann, Katharina, Romanovsky, Andrej A., Possani, Lourival D., Cabot, Peter J., Lewis, Richard J., Vetter, Irina

“…Cold allodynia elicited by local intraplantar injection of the chemotherapeutic agent oxaliplatin is mediated through Nav1.6-expressing peripheral sensory…”
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Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature by Almeida, M Camila, Hew-Butler, Tamara, Soriano, Renato N, Rao, Sara, Wang, Weiya, Wang, Judy, Tamayo, Nuria, Oliveira, Daniela L, Nucci, Tatiane B, Aryal, Prafulla, Garami, Andras, Bautista, Diana, Gavva, Narender R, Romanovsky, Andrej A

“…We studied N-(2-aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride (M8-B), a selective and potent antagonist of the transient…”
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Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis by Csenkey, Alexandra, Jozsa, Gergo, Gede, Noemi, Pakai, Eszter, Tinusz, Benedek, Rumbus, Zoltan, Lukacs, Anita, Gyongyi, Zoltan, Hamar, Peter, Sepp, Robert, Romanovsky, Andrej A, Hegyi, Peter, Vajda, Peter, Garami, Andras

“…In pediatric burns the use of systemic antibiotic prophylaxis is a standard procedure in some burn centers, though its beneficial effect on the infectious…”
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Revised h index for biomedical research by Romanovsky, Andrej A.

“…Proposed by Hirsch as a quantitative measure of the total output of a researcher, the h index does not work well in the field of life sciences, where an…”
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Cold-Induced Thermogenesis and Inflammation-Associated Cold-Seeking Behavior Are Represented by Different Dorsomedial Hypothalamic Sites: A Three-Dimensional Functional Topography Study in Conscious Rats by Wanner, Samuel P, Almeida, M Camila, Shimansky, Yury P, Oliveira, Daniela L, Eales, Justin R, Coimbra, Cândido C, Romanovsky, Andrej A

“…In the past, we showed that large electrolytic lesions of the dorsomedial hypothalamus (DMH) promoted hypothermia in cold-exposed restrained rats, but…”
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The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not by Romanovsky, Andrej A, Almeida, Maria C, Garami, Andras, Steiner, Alexandre A, Norman, Mark H, Morrison, Shaun F, Nakamura, Kazuhiro, Burmeister, Jeffrey J, Nucci, Tatiane B

“…The development of antagonists of the transient receptor potential vanilloid-1 (TRPV1) channel as pain therapeutics has revealed that these compounds cause…”
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Contributions of Different Modes of TRPV1 Activation to TRPV1 Antagonist-Induced Hyperthermia by Garami, Andras, Shimansky, Yury P, Pakai, Eszter, Oliveira, Daniela L, Gavva, Narender R, Romanovsky, Andrej A

“…Transient receptor potential vanilloid-1 (TRPV1) antagonists are widely viewed as next-generation pain therapeutics. However, these compounds cause…”
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Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans by Gavva, Narender R., Treanor, James J.S., Garami, Andras, Fang, Liang, Surapaneni, Sekhar, Akrami, Anna, Alvarez, Francisco, Bak, Annette, Darling, Mary, Gore, Anu, Jang, Graham R., Kesslak, James P., Ni, Liyun, Norman, Mark H., Palluconi, Gabrielle, Rose, Mark J., Salfi, Margaret, Tan, Edward, Romanovsky, Andrej A., Banfield, Christopher, Davar, Gudarz

“…The vanilloid receptor TRPV1 has been identified as a molecular target for the treatment of pain associated with inflammatory diseases and cancer. Hence, TRPV1…”
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Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents by Garami, Andras, Ibrahim, Mohab, Gilbraith, Kerry, Khanna, Rajesh, Pakai, Eszter, Miko, Alexandra, Pinter, Erika, Romanovsky, Andrej A, Porreca, Frank, Patwardhan, Amol M

“…BACKGROUND:Intraoperative hypothermia and postoperative pain control are two important clinical challenges in anesthesiology. Transient receptor potential…”
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Selected contribution: ambient temperature for experiments in rats: a new method for determining the zone of thermal neutrality by Romanovsky, Andrej A, Ivanov, Andrei I, Shimansky, Yury P

“…There is a misbelief that the same animal has the same thermoneutral zone (TNZ) in different experimental setups. In reality, TNZ strongly depends on the…”
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Naturally occurring hypothermia is more advantageous than fever in severe forms of lipopolysaccharide- and Escherichia coli-induced systemic inflammation by Liu, Elaine, Lewis, Kevin, Al-Saffar, Hiba, Krall, Catherine M, Singh, Anju, Kulchitsky, Vladimir A, Corrigan, Joshua J, Simons, Christopher T, Petersen, Scott R, Musteata, Florin M, Bakshi, Chandra S, Romanovsky, Andrej A, Sellati, Timothy J, Steiner, Alexandre A

“…The natural switch from fever to hypothermia observed in the most severe cases of systemic inflammation is a phenomenon that continues to puzzle clinicians and…”
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Leptin: At the crossroads of energy balance and systemic inflammation by Steiner, Alexandre A., Romanovsky, Andrej A.

“…In addition to playing a central role in energy homeostasis, leptin is also an important player in the inflammatory response. Systemic inflammation is…”
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Lipopolysaccharide-induced neuronal activation in the paraventricular and dorsomedial hypothalamus depends on ambient temperature by Wanner, Samuel P, Yoshida, Kyoko, Kulchitsky, Vladimir A, Ivanov, Andrei I, Kanosue, Kazuyuki, Romanovsky, Andrej A

“…Systemic inflammatory response syndrome is associated with either fever or hypothermia, but the mechanisms responsible for switching from one to the other are…”
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Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature by Rudaya, Alla Y, Steiner, Alexandre A, Robbins, Jared R, Dragic, Alexander S, Romanovsky, Andrej A

“…Most published studies of thermoregulatory responses of mice to LPS involved a stressful injection of LPS, were run at a poorly controlled and often subneutral…”
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