Use of antioxidants and trimetazidine in preparation of patients with ischemic heart disease for coronary angiography

Lipid peroxidation, cell stability, lipid spectrum, conjunctival microcirculation, levels of ceruloplasmin and myoglobin were studied in 107 males with ischemic heart disease before and after coronaroangiography by M. Judkins (CAG). It was found that CAG provokes oxidative stress, promotes membranod...

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Bibliographic Details
Published in:	Klinicheskaia meditsina Vol. 79; no. 1; p. 30
Main Authors:	Logacheva, I V, Leshchinskiĭ, L A, Romanova, Z D, Gaĭsin, I R, Perevalov, A P, Karbasnikova, G V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2001
Subjects:	Antioxidants - administration & dosage Antioxidants - therapeutic use Coronary Angiography - adverse effects Coronary Angiography - methods Coronary Circulation - physiology Humans Hyperlipidemias - etiology Hyperlipidemias - prevention & control Lipid Peroxidation - physiology Male Middle Aged Myocardial Ischemia - diagnosis Myocardial Ischemia - physiopathology Trimetazidine - administration & dosage Trimetazidine - therapeutic use Vasodilator Agents - administration & dosage Vasodilator Agents - therapeutic use
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Summary:	Lipid peroxidation, cell stability, lipid spectrum, conjunctival microcirculation, levels of ceruloplasmin and myoglobin were studied in 107 males with ischemic heart disease before and after coronaroangiography by M. Judkins (CAG). It was found that CAG provokes oxidative stress, promotes membranodestructive processes, dyslipidemia and circulation disorders in the bulbar conjunctive. Preventive (3 days before CAG) administration of alpha-tocopherol or emoxipin proved cardioprotective. The highest cytoprotective effect was produced by trimetasidine given 10 days before the procedure.
ISSN:	0023-2149