Search Results - "Romanov, Natalie"

Pervasive Protein Thermal Stability Variation during the Cell Cycle by Becher, Isabelle, Andrés-Pons, Amparo, Romanov, Natalie, Stein, Frank, Schramm, Maike, Baudin, Florence, Helm, Dominic, Kurzawa, Nils, Mateus, André, Mackmull, Marie-Therese, Typas, Athanasios, Müller, Christoph W., Bork, Peer, Beck, Martin, Savitski, Mikhail M.

“…Quantitative mass spectrometry has established proteome-wide regulation of protein abundance and post-translational modifications in various biological…”
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Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation by Kelmer Sacramento, Erika, Kirkpatrick, Joanna M, Mazzetto, Mariateresa, Baumgart, Mario, Bartolome, Aleksandar, Di Sanzo, Simone, Caterino, Cinzia, Sanguanini, Michele, Papaevgeniou, Nikoletta, Lefaki, Maria, Childs, Dorothee, Bagnoli, Sara, Terzibasi Tozzini, Eva, Di Fraia, Domenico, Romanov, Natalie, Sudmant, Peter H, Huber, Wolfgang, Chondrogianni, Niki, Vendruscolo, Michele, Cellerino, Alessandro, Ori, Alessandro

“…A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we…”
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Bactericidal effect of tetracycline in E. coli strain ED1a may be associated with ribosome dysfunction by Khusainov, Iskander, Romanov, Natalie, Goemans, Camille, Turoňová, Beata, Zimmerli, Christian E., Welsch, Sonja, Langer, Julian D., Typas, Athanasios, Beck, Martin

“…Ribosomes translate the genetic code into proteins. Recent technical advances have facilitated in situ structural analyses of ribosome functional states inside…”
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Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline by Hennrich, Marco L., Romanov, Natalie, Horn, Patrick, Jaeger, Samira, Eckstein, Volker, Steeples, Violetta, Ye, Fei, Ding, Ximing, Poisa-Beiro, Laura, Lai, Mang Ching, Lang, Benjamin, Boultwood, Jacqueline, Luft, Thomas, Zaugg, Judith B., Pellagatti, Andrea, Bork, Peer, Aloy, Patrick, Gavin, Anne-Claude, Ho, Anthony D.

“…Diminishing potential to replace damaged tissues is a hallmark for ageing of somatic stem cells, but the mechanisms remain elusive. Here, we present…”
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Co-translational binding of importins to nascent proteins by Seidel, Maximilian, Romanov, Natalie, Obarska-Kosinska, Agnieszka, Becker, Anja, Trevisan Doimo de Azevedo, Nayara, Provaznik, Jan, Nagaraja, Sankarshana R., Landry, Jonathan J. M., Benes, Vladimir, Beck, Martin

“…Various cellular quality control mechanisms support proteostasis. While, ribosome-associated chaperones prevent the misfolding of nascent chains during…”
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Co-translational assembly orchestrates competing biogenesis pathways by Seidel, Maximilian, Becker, Anja, Pereira, Filipa, Landry, Jonathan J. M., de Azevedo, Nayara Trevisan Doimo, Fusco, Claudia M., Kaindl, Eva, Romanov, Natalie, Baumbach, Janina, Langer, Julian D., Schuman, Erin M., Patil, Kiran Raosaheb, Hummer, Gerhard, Benes, Vladimir, Beck, Martin

“…During the co-translational assembly of protein complexes, a fully synthesized subunit engages with the nascent chain of a newly synthesized interaction…”
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Capturing protein communities by structural proteomics in a thermophilic eukaryote by Kastritis, Panagiotis L, O'Reilly, Francis J, Bock, Thomas, Li, Yuanyue, Rogon, Matt Z, Buczak, Katarzyna, Romanov, Natalie, Betts, Matthew J, Bui, Khanh Huy, Hagen, Wim J, Hennrich, Marco L, Mackmull, Marie‐Therese, Rappsilber, Juri, Russell, Robert B, Bork, Peer, Beck, Martin, Gavin, Anne‐Claude

“…The arrangement of proteins into complexes is a key organizational principle for many cellular functions. Although the topology of many complexes has been…”
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Light-sensing via hydrogen peroxide and a peroxiredoxin by Bodvard, Kristofer, Peeters, Ken, Roger, Friederike, Romanov, Natalie, Igbaria, Aeid, Welkenhuysen, Niek, Palais, Gaël, Reiter, Wolfgang, Toledano, Michel B., Käll, Mikael, Molin, Mikael

“…Yeast lacks dedicated photoreceptors; however, blue light still causes pronounced oscillations of the transcription factor Msn2 into and out of the nucleus…”
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Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging by Heinze, Ivonne, Bens, Martin, Calzia, Enrico, Holtze, Susanne, Dakhovnik, Oleksandr, Sahm, Arne, Kirkpatrick, Joanna M, Szafranski, Karol, Romanov, Natalie, Sama, Sai Nagender, Holzer, Kerstin, Singer, Stephan, Ermolaeva, Maria, Platzer, Matthias, Hildebrandt, Thomas, Ori, Alessandro

“…Mammals display a wide range of variation in their lifespan. Investigating the molecular networks that distinguish long- from short-lived species has proven…”
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Glycogen accumulation, central carbon metabolism, and aging of hematopoietic stem and progenitor cells by Poisa-Beiro, Laura, Thoma, Judith, Landry, Jonathan, Sauer, Sven, Yamamoto, Akihisa, Eckstein, Volker, Romanov, Natalie, Raffel, Simon, Hoffmann, Georg F., Bork, Peer, Benes, Vladimir, Gavin, Anne-Claude, Tanaka, Motomu, Ho, Anthony D.

“…Inspired by recent proteomic data demonstrating the upregulation of carbon and glycogen metabolism in aging human hematopoietic stem and progenitor cells…”
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Novel interconnections of HOG signaling revealed by combined use of two proteomic software packages by Janschitz, Marion, Romanov, Natalie, Varnavides, Gina, Hollenstein, David Maria, Gérecová, Gabriela, Ammerer, Gustav, Hartl, Markus, Reiter, Wolfgang

“…Modern quantitative mass spectrometry (MS)-based proteomics enables researchers to unravel signaling networks by monitoring proteome-wide cellular responses to…”
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A Staphylococcus aureus Proteome Overview: Shared and Specific Proteins and Protein Complexes from Representative Strains of All Three Clades by Liang, Chunguang, Schaack, Dominik, Srivastava, Mugdha, Gupta, Shishir K, Sarukhanyan, Edita, Giese, Anne, Pagels, Martin, Romanov, Natalie, Pané-Farré, Jan, Fuchs, Stephan, Dandekar, Thomas

“…is an important model organism and pathogen. This proteome overview details shared and specific proteins and selected virulence-relevant protein complexes from…”
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Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals by Romanov, Natalie, Kuhn, Michael, Aebersold, Ruedi, Ori, Alessandro, Beck, Martin, Bork, Peer

“…Proteotypes, like genotypes, have been found to vary between individuals in several studies, but consistent molecular functional traits across studies remain…”
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Decoding the function of Atg13 phosphorylation reveals a role of Atg11 in bulk autophagy initiation by Bhattacharya, Anuradha, Torggler, Raffaela, Reiter, Wolfgang, Romanov, Natalie, Licheva, Mariya, Ciftci, Akif, Mari, Muriel, Kolb, Lena, Kaiser, Dominik, Reggiori, Fulvio, Ammerer, Gustav, Hollenstein, David M, Kraft, Claudine

“…Autophagy is initiated by the assembly of multiple autophagy-related proteins that form the phagophore assembly site where autophagosomes are formed. Atg13 is…”
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Identifying protein kinase-specific effectors of the osmostress response in yeast by Romanov, Natalie, Hollenstein, David Maria, Janschitz, Marion, Ammerer, Gustav, Anrather, Dorothea, Reiter, Wolfgang

“…The budding yeast reacts to increased external osmolarity by modifying many cellular processes. Adaptive signaling relies primarily on the high-osmolarity…”
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A phosphatase-centric mechanism drives stress signaling response by Hollenstein, David Maria, Gérecová, Gabriela, Romanov, Natalie, Ferrari, Jessica, Veis, Jiri, Janschitz, Marion, Beyer, Reinhard, Schüller, Christoph, Ogris, Egon, Hartl, Markus, Ammerer, Gustav, Reiter, Wolfgang

“…Changing environmental cues lead to the adjustment of cellular physiology by phosphorylation signaling networks that typically center around kinases as active…”
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Proteomics Analysis of Cellular Network in Human Bone Marrow Reveals Lineage Skewing Towards Megakaryocytes and Decrease in Lymphoid Development upon Aging by Ho, Anthony D., Horn, Patrick, Hennrich, Marco, Jaeger, Samira, Romanov, Natalie, Ding, Ximing, Bork, Peer, Aloy, Patrick, Gavin, Anne-Claude

“…Background: Whereas proteomics analyses at a cellular level have been performed in murine HPC, most proteomics studies on human material have thus far focused…”
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Proteome Analyses and Single-Cell RNA Sequencing Reveal Age-Dependent Re-Wiring of Central Carbon Metabolism in Myeloid-Biased Subsets of Human Hematopoietic Stem Cells by Hennrich, Marco L, Romanov, Natalie, Horn, Patrick, Jaeger, Samira, Eckstein, Volker, Poisa-Beiro, Laura, Boultwood, Jacqueline, Luft, Thomas, Pellagatti, Andrea, Bork, Peer, Aloy, Patrick, Gavin, Anne-Claude, Ho, Anthony D.

“…Background: Diminishing potential to replace damaged tissues is a hallmark for aging of somatic stem cells, but the mechanisms leading to aging remain elusive…”
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Abstract 5737: Precision oncology driven real world clinical genomics data mining of MET alterations, TMB, and PDL-1 to empower indication agnostic patient enrollment and combination strategies by Feng, Zheng, Pignon, Jean-Christophe, Sharaf, Radwa, Romanov, Natalie, Doudement, Julien, Albacker, Lee A., Kurata, Noriaki, Smith, Neil R., Matsushita, Nobutoshi, Scheuenpflug, Juergen

“…Abstract Background: Following MET inhibitor and checkpoint inhibitor approvals, it is essential to identify cancer indications that harbor molecular…”
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