Search Results - "Romano Regazzi"

MicroRNAs as therapeutic targets for the treatment of diabetes mellitus and its complications by Regazzi, Romano

“…Diabetes mellitus is a very common metabolic disorder affecting more than 400 million people worldwide. Currently available treatments permit to manage the…”
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Circulating microRNAs as novel biomarkers for diabetes mellitus by Guay, Claudiane, Regazzi, Romano

“…Measuring circulating levels of microRNAs is a promising strategy for identifying people at risk of developing diabetes mellitus; however, several obstacles…”
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Exosomes as new players in metabolic organ cross‐talk by Guay, Claudiane, Regazzi, Romano

“…Blood glucose homeostasis requires a constant communication between insulin‐secreting and insulin‐sensitive cells. A wide variety of circulating factors,…”
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Crosstalk between Macrophages and Pancreatic β-Cells in Islet Development, Homeostasis and Disease by Cosentino, Cristina, Regazzi, Romano

“…Macrophages are highly heterogeneous and plastic immune cells with peculiar characteristics dependent on their origin and microenvironment. Following pathogen…”
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Circular RNAs as Novel Regulators of β-Cell Functions under Physiological and Pathological Conditions by Brozzi, Flora, Regazzi, Romano

“…Circular RNAs (circRNAs) constitute a large class of non-coding RNAs characterized by a covalently closed circular structure. They originate during mRNA…”
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Mechanisms Underlying the Expansion and Functional Maturation of β-Cells in Newborns: Impact of the Nutritional Environment by Jacovetti, Cécile, Regazzi, Romano

“…The functional maturation of insulin-secreting β-cells is initiated before birth and is completed in early postnatal life. This process has a critical impact…”
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A circular RNA generated from an intron of the insulin gene controls insulin secretion by Stoll, Lisa, Rodríguez-Trejo, Adriana, Guay, Claudiane, Brozzi, Flora, Bayazit, Mustafa Bilal, Gattesco, Sonia, Menoud, Véronique, Sobel, Jonathan, Marques, Ana Claudia, Venø, Morten Trillingsgaard, Esguerra, Jonathan Lou S., Barghouth, Mohammad, Suleiman, Mara, Marselli, Lorella, Kjems, Jørgen, Eliasson, Lena, Renström, Erik, Bouzakri, Karim, Pinget, Michel, Marchetti, Piero, Regazzi, Romano

“…Fine-tuning of insulin release from pancreatic β-cells is essential to maintain blood glucose homeostasis. Here, we report that insulin secretion is regulated…”
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Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs by Lovis, Pascal, Gattesco, Sonia, Regazzi, Romano

“…Fine-tuning of insulin secretion from pancreatic beta-cells participates in blood glucose homeostasis. Defects in this process can lead to chronic…”
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Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells by Guay, Claudiane, Menoud, Véronique, Rome, Sophie, Regazzi, Romano

“…Diabetes mellitus is a common metabolic disorder characterized by dysfunction of insulin-secreting pancreatic beta-cells. MicroRNAs are important regulators of…”
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Circular RNAs as novel regulators of β-cell functions in normal and disease conditions by Stoll, Lisa, Sobel, Jonathan, Rodriguez-Trejo, Adriana, Guay, Claudiane, Lee, Kailun, Venø, Morten Trillingsgaard, Kjems, Jørgen, Laybutt, D. Ross, Regazzi, Romano

“…There is strong evidence for an involvement of different classes of non-coding RNAs, including microRNAs and long non-coding RNAs, in the regulation of β-cell…”
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Emerging Classes of Small Non-Coding RNAs With Potential Implications in Diabetes and Associated Metabolic Disorders by Jacovetti, Cécile, Bayazit, Mustafa Bilal, Regazzi, Romano

“…Most of the sequences in the human genome do not code for proteins but generate thousands of non-coding RNAs (ncRNAs) with regulatory functions…”
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Scrt1, a transcriptional regulator of β-cell proliferation identified by differential chromatin accessibility during islet maturation by Sobel, Jonathan, Guay, Claudiane, Elhanani, Ofer, Rodriguez-Trejo, Adriana, Stoll, Lisa, Menoud, Véronique, Jacovetti, Cécile, Walker, Michael D., Regazzi, Romano

“…Glucose-induced insulin secretion, a hallmark of mature β-cells, is achieved after birth and is preceded by a phase of intense proliferation. These events…”
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The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development by Tenenbaum, Mathie, Plaisance, Valérie, Boutry, Raphael, Pawlowski, Valérie, Jacovetti, Cécile, Sanchez-Parra, Clara, Ezanno, Hélène, Bourry, Julien, Beeler, Nicole, Pasquetti, Gianni, Gmyr, Valery, Dalle, Stéphane, Kerr-Conte, Julie, Pattou, François, Hirai, Syu-ichi, Regazzi, Romano, Bonnefond, Amélie, Froguel, Philippe, Abderrahmani, Amar

“…Unveiling the key pathways underlying postnatal beta-cell proliferation can be instrumental to decipher the mechanisms of beta-cell mass plasticity to…”
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Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction by LOVIS, Pascal, ROGGLI, Elodie, ROSS LAYBUTT, D, GATTESCO, Sonia, YANG, Jiang-Yan, WIDMANN, Christian, ABDERRAHMANI, Amar, REGAZZI, Romano

“…Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction Pascal Lovis 1 , Elodie Roggli 1 , D. Ross Laybutt 2 , Sonia…”
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MicroRNA-9 Controls the Expression of Granuphilin/Slp4 and the Secretory Response of Insulin-producing Cells by Plaisance, Valérie, Abderrahmani, Amar, Perret-Menoud, Véronique, Jacquemin, Patrick, Lemaigre, Frédéric, Regazzi, Romano

“…Insulin release from pancreatic β-cells plays an essential role in blood glucose homeostasis. Several proteins controlling insulin exocytosis have been…”
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Publisher Correction: Loss-of-function of the long non-coding RNA A830019P07Rik in mice does not affect insulin expression and secretion by Guay, Claudiane, Abdulkarim, Baroj, Tan, Jennifer Y., Dubuis, Gilles, Rütti, Sabine, Laybutt, David Ross, Widmann, Christian, Regazzi, Romano, Marques, Ana Claudia

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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The mitochondrial tRNA-derived fragment, mt-tRF-LeuTAA, couples mitochondrial metabolism to insulin secretion by Jacovetti, Cecile, Donnelly, Chris, Menoud, Véronique, Suleiman, Mara, Cosentino, Cristina, Sobel, Jonathan, Wu, Kejing, Bouzakri, Karim, Marchetti, Piero, Guay, Claudiane, Kayser, Bengt, Regazzi, Romano

“…The contribution of the mitochondrial electron transfer system to insulin secretion involves more than just energy provision. We identified a small RNA…”
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Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes by Motterle, Anna, Gattesco, Sonia, Peyot, Marie-Line, Esguerra, Jonathan Lou S., Gomez-Ruiz, Ana, Laybutt, D. Ross, Gilon, Patrick, Burdet, Frédéric, Ibberson, Mark, Eliasson, Lena, Prentki, Marc, Regazzi, Romano

“…Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involvement of microRNAs is well established, the contribution of long…”
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Fast Subplasma Membrane Ca2+ Transients Control Exo-Endocytosis of Synaptic-Like Microvesicles in Astrocytes by Marchaland, Julie, Cali, Corrado, Voglmaier, Susan M, Li, Haiyan, Regazzi, Romano, Edwards, Robert H, Bezzi, Paola

“…Astrocytes are the most abundant glial cell type in the brain. Although not apposite for long-range rapid electrical communication, astrocytes share with…”
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Loss-of-function of the long non-coding RNA A830019P07Rik in mice does not affect insulin expression and secretion by Guay, Claudiane, Abdulkarim, Baroj, Tan, Jennifer Y., Dubuis, Gilles, Rütti, Sabine, Laybutt, David Ross, Widmann, Christian, Regazzi, Romano, Marques, Ana Claudia

“…Long non-coding RNAs (lncRNAs) contribute to diverse cellular functions and the dysregulation of their expression or function can contribute to diseases,…”
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