Search Results - "Romano, Audrey"

Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment by Lee, Sang Hun, Charmoy, Melanie, Romano, Audrey, Paun, Andrea, Chaves, Mariana M, Cope, Frederick O, Ralph, David A, Sacks, David L

“…The origin and functional specialization of dermal macrophages in cutaneous infections have been little studied. In this paper, we show that a strain of (…”
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Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania by Inbar, Ehud, Shaik, Jahangheer, Iantorno, Stefano A, Romano, Audrey, Nzelu, Chukwunonso O, Owens, Katherine, Sanders, Mandy J, Dobson, Deborah, Cotton, James A, Grigg, Michael E, Beverley, Stephen M, Sacks, David

“…Hybrid genotypes have been repeatedly described among natural isolates of Leishmania, and the recovery of experimental hybrids from sand flies co-infected with…”
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Skin parasite landscape determines host infectiousness in visceral leishmaniasis by Doehl, Johannes S. P., Bright, Zoe, Dey, Shoumit, Davies, Helen, Magson, John, Brown, Najmeeyah, Romano, Audrey, Dalton, Jane E., Pinto, Ana I., Pitchford, Jon W., Kaye, Paul M.

“…Increasing evidence suggests that the infectiousness of patients for the sand fly vector of visceral leishmaniasis is linked to parasites found in the skin…”
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Cross-species genetic exchange between visceral and cutaneous strains of Leishmania in the sand fly vector by Romano, Audrey, Inbar, Ehud, Debrabant, Alain, Charmoy, Melanie, Lawyer, Phillip, Ribeiro-Gomes, Flavia, Barhoumi, Mourad, Grigg, Michael, Shaik, Jahangheer, Dobson, Deborah, Beverley, Stephen M., Sacks, David L., James, Anthony A.

“…Significance Protozoan parasites of the genus Leishmania are transmitted by sand flies and produce diseases in humans ranging from localized cutaneous lesions…”
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Fatal progression of experimental visceral leishmaniasis is associated with intestinal parasitism and secondary infection by commensal bacteria, and is delayed by antibiotic prophylaxis by Lewis, Michael D, Paun, Andrea, Romano, Audrey, Langston, Harry, Langner, Charlotte A, Moore, Ian N, Bock, Kevin W, Francisco, Amanda Fortes, Brenchley, Jason M, Sacks, David L

“…Leishmania donovani causes visceral leishmaniasis (VL), which is typically fatal without treatment. There is substantial variation between individuals in rates…”
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Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection by Peters, Nathan C, Pagán, Antonio J, Lawyer, Phillip G, Hand, Timothy W, Henrique Roma, Eric, Stamper, Lisa W, Romano, Audrey, Sacks, David L

“…In contrast to the ability of long-lived CD8(+) memory T cells to mediate protection against systemic viral infections, the relationship between CD4(+) T cell…”
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IL‐22 and IL‐22 binding protein (IL‐22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections by Sertorio, Mathieu, Hou, Xunya, Carmo, Rodrigo F., Dessein, Hélia, Cabantous, Sandrine, Abdelwahed, Mohammed, Romano, Audrey, Albuquerque, Fernanda, Vasconcelos, Luydson, Carmo, Theomira, Li, Jun, Varoquaux, Arthur, Arnaud, Violaine, Oliveira, Pablo, Hamdoun, Anas, He, Hongbin, Adbelmaboud, Suzan, Mergani, Adil, Zhou, Jie, Monis, Ahmed, Pereira, Leila Beltrao, Halfon, Philippe, Bourlière, Marc, Parana, Raymundo, dos Reis, Mitermayer, Gonnelli, David, Moura, Patricia, Elwali, Nasr Eldin, Argiro, Laurent, Li, Yuesheng, Dessein, Alain

“…Interleukin (IL)‐22 acts on epithelia, hepatocytes, and pancreatic cells and stimulates innate immunity, tissue protection, and repair. IL‐22 may also cause…”
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The mating competence of geographically diverse Leishmania major strains in their natural and unnatural sand fly vectors by Inbar, Ehud, Akopyants, Natalia S, Charmoy, Melanie, Romano, Audrey, Lawyer, Phillip, Elnaiem, Dia-Eldin A, Kauffmann, Florence, Barhoumi, Mourad, Grigg, Michael, Owens, Katherine, Fay, Michael, Dobson, Deborah E, Shaik, Jahangheer, Beverley, Stephen M, Sacks, David

“…Invertebrate stages of Leishmania are capable of genetic exchange during their extracellular growth and development in the sand fly vector. Here we explore two…”
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Interferon-γ-Producing CD4 + T Cells Drive Monocyte Activation in the Bone Marrow During Experimental Leishmania donovani Infection by Romano, Audrey, Brown, Najmeeyah, Ashwin, Helen, Doehl, Johannes S P, Hamp, Jonathan, Osman, Mohamed, Dey, Nidhi, Rani, Gulab Fatima, Ferreira, Tiago Rodrigues, Kaye, Paul M

“…Ly6C inflammatory monocytes develop in the bone marrow and migrate to the site of infection during inflammation. Upon recruitment, Ly6C monocytes can…”
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Spatial Point Pattern Analysis Identifies Mechanisms Shaping the Skin Parasite Landscape in Leishmania donovani Infection by Doehl, Johannes S P, Ashwin, Helen, Brown, Najmeeyah, Romano, Audrey, Carmichael, Samuel, Pitchford, Jon W, Kaye, Paul M

“…Increasing evidence suggests that in hosts infected with parasites of the complex, transmission of infection to the sand fly vector is linked to parasite…”
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FOXP3+ Regulatory T Cells in Hepatic Fibrosis and Splenomegaly Caused by Schistosoma japonicum: The Spleen May Be a Major Source of Tregs in Subjects with Splenomegaly by Romano, Audrey, Hou, Xunya, Sertorio, Mathieu, Dessein, Hélia, Cabantous, Sandrine, Oliveira, Pablo, Li, Jun, Oyegue, Sandrine, Arnaud, Violaine, Luo, Xinsong, Daujat-Chavanieu, Martine, Chavanieu, Martine, Mariani, Odette, Sastre, Xavier, Dombey, Anne-Marie, He, Hongbin, Li, Yuesheng, Dessein, Alain

“…Schistosoma eggs cause chronic liver inflammation and a complex disease characterized by hepatic fibrosis (HF) and splenomegaly (SplM). FOXP3+ Tregs could…”
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IL2RA genetic variants reduce IL-2-dependent responses and aggravate human cutaneous leishmaniasis by Oliveira, Pablo R S, Dessein, Hélia, Romano, Audrey, Cabantous, Sandrine, de Brito, Maria E F, Santoro, Ferrucio, Pitta, Maira G R, Pereira, Valéria, Pontes-de-Carvalho, Lain C, Rodrigues, Jr, Virmondes, Rafati, Sima, Argiro, Laurent, Dessein, Alain J

“…The outcome of Leishmania infections varies substantially, depending on the host and the parasite strain; infection may be asymptomatic or cause mild or severe…”
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Divergent roles for Ly6C+CCR2+CX3CR1+ inflammatory monocytes during primary or secondary infection of the skin with the intra-phagosomal pathogen Leishmania major by Romano, Audrey, Carneiro, Matheus B H, Doria, Nicole A, Roma, Eric H, Ribeiro-Gomes, Flavia L, Inbar, Ehud, Lee, Sang Hun, Mendez, Jonatan, Paun, Andrea, Sacks, David L, Peters, Nathan C

“…Inflammatory monocytes can be manipulated by environmental cues to perform multiple functions. To define the role of monocytes during primary or secondary…”
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In Situ Expression of Regulatory Cytokines by Heart Inflammatory Cells in Chagas' Disease Patients with Heart Failure by Rodrigues, Denise Bertulucci Rocha, Reis, Marlene Antônia dos, Romano, Audrey, Pereira, Sanívia Aparecida de Lima, Teixeira, Vicente de Paula Antunes, Tostes Junior, Sebastião, Rodrigues, Virmondes

“…Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi. The immune system plays an important role in the reduction of parasite load, but may…”
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Correction: FOXP3+ Regulatory T Cells in Hepatic Fibrosis and Splenomegaly Caused by Schistosoma japonicum: The Spleen May Be a Major Source of Tregs in Subjects with Splenomegaly by Romano, Audrey, Hou, Xunya, Sertorio, Mathieu, Dessein, Hélia, Cabantous, Sandrine, Oliveira, Pablo, Li, Jun, Oyegue, Sandrine, Arnaud, Violaine, Luo, Xinsong, Daujat-Chavanieu, Martine, Mariani, Odette, Sastre, Xavier, Dombey, Anne-Marie, He, Hongbin, Li, Yuesheng, Dessein, Alain

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The Nlrp3 inflammasome, IL‐1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice by Charmoy, Melanie, Hurrell, Benjamin P., Romano, Audrey, Lee, Sang Hun, Ribeiro‐Gomes, Flavia, Riteau, Nicolas, Mayer‐Barber, Katrin, Tacchini‐Cottier, Fabienne, Sacks, David L.

“…Infection of C57BL/6 mice with most Leishmania major strains results in a healing lesion and clearance of parasites from the skin. Infection of C57BL/6 mice…”
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Malat1 Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells by Hewitson, James P, West, Katie A, James, Kylie R, Rani, Gulab Fatima, Dey, Nidhi, Romano, Audrey, Brown, Najmeeyah, Teichmann, Sarah A, Kaye, Paul M, Lagos, Dimitris

“…Despite extensive mapping of long noncoding RNAs in immune cells, their function in vivo remains poorly understood. In this study, we identify over 100 long…”
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A phase II study evaluating the efficacy of niraparib and dostarlimab (TSR-042) in recurrent/metastatic head and neck squamous cell carcinoma by Karivedu, Vidhya, Riaz, Muhammad Kashif, Mathews, Maria, Kurtzweil, Nicky, Monroe, Ilaina, Romano, Audrey, Wise-Draper, Trisha Michel

“…TPS6105 Background: Despite improvement in outcomes with checkpoint (PD-1) inhibitors in some patients (pts) with recurrent and metastatic head and neck…”
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Phase II study evaluating the efficacy of niraparib and dostarlimab (TSR-042) in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) patients by Zamulko, Olga, Karivedu, Vidhya, Riaz, Muhammad Kashif, Monroe, Ilaina, Romano, Audrey, Mulanda, Rachel, Kurtzweil, Nicky, Forsythe, Allison, Allen, Casey, Harun, Nusrat, Wise-Draper, Trisha M.

“…6046 Background: Patients with recurrent and/or metastatic (R/M) HNSCC have poor overall survival. Immune checkpoint inhibitors (ICIs), specifically programmed…”
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Th1-Th2 Cross-Regulation Controls Early Leishmania Infection in the Skin by Modulating the Size of the Permissive Monocytic Host Cell Reservoir by Carneiro, Matheus Batista, Lopes, Mateus Eustáquio, Hohman, Leah S., Romano, Audrey, David, Bruna Araujo, Kratofil, Rachel, Kubes, Paul, Workentine, Matthew L., Campos, Alexandre C., Vieira, Leda Quercia, Peters, Nathan C.

“…The impact of T helper (Th) 1 versus Th2 immunity on intracellular infections is attributed to classical versus alternative activation of macrophages leading…”
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