Search Results - "Romanino, Klaas"

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy by Castets, Perrine, Lin, Shuo, Rion, Nathalie, Di Fulvio, Sabrina, Romanino, Klaas, Guridi, Maitea, Frank, Stephan, Tintignac, Lionel A., Sinnreich, Michael, Rüegg, Markus A.

“…Autophagy is a catabolic process that ensures homeostatic cell clearance and is deregulated in a growing number of myopathological conditions. Although FoxO3…”
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Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy by Risson, Valérie, Mazelin, Laetitia, Roceri, Mila, Sanchez, Hervé, Moncollin, Vincent, Corneloup, Claudine, Richard-Bulteau, Hélène, Vignaud, Alban, Baas, Dominique, Defour, Aurélia, Freyssenet, Damien, Tanti, Jean-François, Le-Marchand-Brustel, Yannick, Ferrier, Bernard, Conjard-Duplany, Agnès, Romanino, Klaas, Bauché, Stéphanie, Hantaï, Daniel, Mueller, Matthias, Kozma, Sara C, Thomas, George, Rüegg, Markus A, Ferry, Arnaud, Pende, Mario, Bigard, Xavier, Koulmann, Nathalie, Schaeffer, Laurent, Gangloff, Yann-Gaël

“…Mammalian target of rapamycin (mTOR) is a key regulator of cell growth that associates with raptor and rictor to form the mTOR complex 1 (mTORC1) and mTORC2,…”
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Yin Yang 1 Deficiency in Skeletal Muscle Protects against Rapamycin-Induced Diabetic-like Symptoms through Activation of Insulin/IGF Signaling by Blättler, Sharon M., Cunningham, John T., Verdeguer, Francisco, Chim, Helen, Haas, Wilhelm, Liu, Huifei, Romanino, Klaas, Rüegg, Markus A., Gygi, Steven P., Shi, Yang, Puigserver, Pere

“…Rapamycin and its derivatives are mTOR inhibitors used in tissue transplantation and cancer therapy. A percentage of patients treated with these inhibitors…”
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Defective Mitochondrial Morphology and Bioenergetic Function in Mice Lacking the Transcription Factor Yin Yang 1 in Skeletal Muscle by Blättler, Sharon M., Verdeguer, Francisco, Liesa, Marc, Cunningham, John T., Vogel, Rutger O., Chim, Helen, Liu, Huifei, Romanino, Klaas, Shirihai, Orian S., Vazquez, Francisca, Rüegg, Markus A., Shi, Yang, Puigserver, Pere

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Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy by Bentzinger, C Florian, Lin, Shuo, Romanino, Klaas, Castets, Perrine, Guridi, Maitea, Summermatter, Serge, Handschin, Christoph, Tintignac, Lionel A, Hall, Michael N, Rüegg, Markus A

“…Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master…”
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Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism by Guridi, Maitea, Kupr, Barbara, Romanino, Klaas, Lin, Shuo, Falcetta, Denis, Tintignac, Lionel, Rüegg, Markus A

“…The mammalian target of rapamycin complex 1 (mTORC1) is a central node in a network of signaling pathways controlling cell growth and survival. This…”
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Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function by Romanino, Klaas, Mazelin, Laetitia, Albert, Verena, Conjard-Duplany, Agnès, Lin, Shuo, Bentzinger, C. Florian, Handschin, Christoph, Puigserver, Pere, Zorzato, Francesco, Schaeffer, Laurent, Gangloff, Yann-Gaël, Rüegg, Markus A

“…Mammalian target of rapamycin complex 1 (mTORC1) is central to the control of cell, organ, and body size. Skeletal muscle-specific inactivation of mTORC1 in…”
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Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy by Bentzinger, C. Florian, Romanino, Klaas, Cloëtta, Dimitri, Lin, Shuo, Mascarenhas, Joseph B., Oliveri, Filippo, Xia, Jinyu, Casanova, Emilio, Costa, Céline F., Brink, Marijke, Zorzato, Francesco, Hall, Michael N., Rüegg, Markus A.

“…Mammalian target of rapamycin (mTOR) is a central controller of cell growth. mTOR assembles into two distinct multiprotein complexes called mTOR complex 1…”
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Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex by Lopez, Rubén J, Mosca, Barbara, Treves, Susan, Maj, Marcin, Bergamelli, Leda, Calderon, Juan C, Bentzinger, C Florian, Romanino, Klaas, Hall, Michael N, Rüegg, Markus A, Delbono, Osvaldo, Caputo, Carlo, Zorzato, Francesco

“…The protein mammalian target of rapamycin (mTOR) is a serine/threonine kinase regulating a number of biochemical pathways controlling cell growth. mTOR exists…”
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Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy by Risson, Valérie, Mazelin, Laetitia, Roceri, Mila, Sanchez, Hervé, Moncollin, Vincent, Corneloup, Claudine, Richard-Bulteau, Hélène, Vignaud, Alban, Baas, Dominique, Defour, Aurélia, Freyssenet, Damien, Tanti, Jean-François, Le-Marchand-Brustel, Yannick, Ferrier, Bernard, Conjard-Duplany, Agnés, Romanino, Klaas, Bauché, Stéphanie, Hantaï, Daniel, Mueller, Matthias, Kozma, Sara C., Thomas, George, Rüegg, Markus A., Ferry, Arnaud, Pende, Mario, Bigard, Xavier, Koulmann, Nathalie, Schaeffer, Laurent, Gangloff, Yann-Gaël

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