Search Results - "Romanienko, Peter J"

Distinct Properties of the XY Pseudoautosomal Region Crucial for Male Meiosis by Kauppi, Liisa, Barchi, Marco, Baudat, Frédéric, Romanienko, Peter J, Keeney, Scott, Jasin, Maria

“…Meiosis requires that each chromosome find its homologous partner and undergo at least one crossover. X-Y chromosome segregation hinges on efficient…”
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Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination by Abreu, Carla M., Prakash, Rohit, Romanienko, Peter J., Roig, Ignasi, Keeney, Scott, Jasin, Maria

“…The DNA-damage repair pathway homologous recombination (HR) requires factors that promote the activity of strand-exchange protein RAD51 and its…”
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XRCC3 loss leads to midgestational embryonic lethality in mice by Prakash, Rohit, Freyer, Laina, Saiz, Néstor, Gavrilov, Svetlana, Wang, Raymond Q., Romanienko, Peter J., Lacy, Elizabeth, Hadjantonakis, Anna-Katerina, Jasin, Maria

“…RAD51 paralogs are key components of the homologous recombination (HR) machinery. Mouse mutants have been reported for four of the canonical RAD51 paralogs,…”
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Bcl-x short-isoform is essential for maintaining homeostasis of multiple tissues by Keller, Mariko Aoyagi, Huang, Chun-yang, Ivessa, Andreas, Singh, Sukhwinder, Romanienko, Peter J., Nakamura, Michinari

“…BCL-2-like protein 1 (BCL2L1) is a key component of cell survival and death mechanisms. Its dysregulation and altered ratio of splicing variants associate with…”
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H2AX Is Required for Chromatin Remodeling and Inactivation of Sex Chromosomes in Male Mouse Meiosis by Fernandez-Capetillo, Oscar, Mahadevaiah, Shantha K., Celeste, Arkady, Romanienko, Peter J., Camerini-Otero, R.Daniel, Bonner, William M., Manova, Katia, Burgoyne, Paul, Nussenzweig, André

“…During meiotic prophase in male mammals, the X and Y chromosomes condense to form a macrochromatin body, termed the sex, or XY, body, within which X- and…”
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A Vector with a Single Promoter for In Vitro Transcription and Mammalian Cell Expression of CRISPR gRNAs by Romanienko, Peter J, Giacalone, Joseph, Ingenito, Joanne, Wang, Yijie, Isaka, Mayumi, Johnson, Thomas, You, Yun, Mark, Willie H

“…The genomes of more than 50 organisms have now been manipulated due to rapid advancement of gene editing technology. One way to perform gene editing in the…”
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Genomic Instability in Mice Lacking Histone H2AX by Celeste, Arkady, Petersen, Simone, Romanienko, Peter J., Fernandez-Capetillo, Oscar, Chen, Hua Tang, Sedelnikova, Olga A., Bernardo Reina-San-Martin, Coppola, Vincenzo, Meffre, Eric, Difilippantonio, Michael J., Redon, Christophe, Pilch, Duane R., Olaru, Alexandru, Eckhaus, Michael, Camerini-Otero, R. Daniel, Tessarollo, Lino, Livak, Ferenc, Manova, Katia, Bonner, William M., Nussenzweig, Michel C., Nussenzweig, André

“…Higher order chromatin structure presents a barrier to the recognition and repair of DNA damage. Double-strand breaks (DSBs) induce histone H2AX…”
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Homology-Directed Repair is a Major Double-Strand Break Repair Pathway in Mammalian Cells by Liang, Feng, Han, Mingguang, Romanienko, Peter J., Jasin, Maria

“…Mammalian cells have been presumed to repair potentially lethal chromosomal double-strand breaks (DSBs) in large part by processes that do not require homology…”
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The Hop2 Protein Has a Direct Role in Promoting Interhomolog Interactions during Mouse Meiosis by Petukhova, Galina V., Romanienko, Peter J., Camerini-Otero, R.Daniel

“…The S. cerevisiae Hop2 protein and its fission yeast homolog Meu13 are required for proper homologous chromosome pairing and recombination during meiosis. The…”
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Medulloblastomas Initiated by Homologous Recombination Defects in Mice by Lu, Huimei, Wang, Yuan, Chaudhary, Shipra, Balaga, Varshita, Ke, Hua, Shi, Fuqian, Liu, Jingmei, Huo, Yanying, Romanienko, Peter J., Xia, Bing, De, Subhajyoti, Chan, Chang S., Shen, Zhiyuan

“…Germline mutations of homologous-recombination (HR) genes are among the top contributors to medulloblastomas. A significant portion of human medulloblastomas…”
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SETD4-mediated KU70 methylation suppresses apoptosis by Wang, Yuan, Liu, Bochao, Lu, Huimei, Liu, Jingmei, Romanienko, Peter J, Montelione, Gaetano T, Shen, Zhiyuan

“…The mammalian KU70 is a pleiotropic protein functioning in DNA repair and cytoplasmic suppression of apoptosis. We report a regulatory mechanism by which…”
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Gene expression profiles of Spo11−/− mouse testes with spermatocytes arrested in meiotic prophase I by Smirnova, Natalya A, Romanienko, Peter J, Khil, Pavel P, Camerini-Otero, R Daniel

“…Spo11, a meiosis-specific protein, introduces double-strand breaks on chromosomal DNA and initiates meiotic recombination in a wide variety of organisms. Mouse…”
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DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1 by Fernandez-Capetillo, Oscar, Chen, Hua-Tang, Celeste, Arkady, Ward, Irene, Romanienko, Peter J, Morales, Julio C, Naka, Kazuhito, Xia, Zhenfang, Camerini-Otero, R Daniel, Motoyama, Noboru, Carpenter, Phillip B, Bonner, William M, Chen, Junjie, Nussenzweig, André

“…Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR), including the initiation of cell…”
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The mouse X chromosome is enriched for sex-biased genes not subject to selection by meiotic sex chromosome inactivation by Camerini-Otero, R Daniel, Khil, Pavel P, Smirnova, Natalya A, Romanienko, Peter J

“…Sex chromosomes are subject to sex-specific selective evolutionary forces. One model predicts that genes with sex-biased expression should be enriched on the X…”
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SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm[superscript -/-] spermatocytes by Bellani, Marina A, Romanienko, Peter J, Cairatti, Damian A, Camerini-Otero, R. Daniel

“…SPO11 introduces double-strand breaks (DSBs) that trigger the phosphorylation of H2AX during meiotic prophase. In mice, SPO11 is strictly required for…”
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Cloning, Characterization, and Localization of Mouse and Human SPO11 by Romanienko, Peter J., Camerini-Otero, R.Daniel

“…Spo11 is a meiosis-specific protein in yeast that has been found covalently bound to DNA double-strand breaks (DSBs) during the early stages of meiosis. These…”
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Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cells by Smih, Fatima, Rouet, Philippe, Romanienko, Peter J., Jasin, Maria

“…Double-strand breaks (DSBs) are recomblnogenlc lesions In chromosomal DNA in yeast, Drosophlla and Caenortiabdltls elegans. Recent studies In mammalian cells…”
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Palindrome resolution and recombination in the mammalian germ line by Akgün, Ercan, Zahn, Jeffrey, Baumes, Susan, Brown, Greg, Liang, Feng, Romanienko, Peter J., Lewis, Susanna, Jasin, Maria

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Chromosomal Double-Strand Break Repair in Ku80-Deficient Cells by Liang, Feng, Romanienko, Peter J., Weaver, David T., Jeggo, Penny A., Jasin, Maria

“…The x-ray sensitive hamster cell line xrs-6 is deficient in DNA double-strand break (DSB) repair and exhibits impaired V(D)J recombination. The molecular…”
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The Mouse Spo11 Gene Is Required for Meiotic Chromosome Synapsis by Romanienko, Peter J, Camerini-Otero, R.Daniel

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