The Contribution of Rapid Intraoperative Cytology to the Improvement of Ovarian Cancer Staging

The Contribution of Rapid Intraoperative Cytology to the Improvement of Ovarian Cancer Staging

Objective. The goal of this work was to evaluate the use of intraoperative cytology in the improvement of ovarian cancer staging. Methods. Fifty-two patients with clinical stage IA–IIB ovarian cancer underwent peritoneal washing (PW) cytology and imprint cytology performed on retroperitoneal lymph n...

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Bibliographic Details
Published in:Gynecologic oncology Vol. 86; no. 3; pp. 244 - 249
Main Authors: Anastasiadis, P.G., Romanidis, K.N., Polichronidis, A., Koutlaki, N.G., Tamiolakis, D., Simopoulos, K.
Format: Journal Article
Language:English
Published: San Diego, CA Elsevier Inc 01-09-2002
Elsevier
Subjects:
Biological and medical sciences
Biopsy
Cytological Techniques - methods
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
imprint cytology
Intraoperative Period
lymph node biopsy
Lymph Nodes - pathology
Medical sciences
Neoplasm Staging - methods
ovarian cancer staging
Ovarian Neoplasms - pathology
Ovarian Neoplasms - surgery
Peritoneal Cavity - pathology
peritoneal washing cytology
Tumors
peritoneal washing cytology
lymph node biopsy
imprint cytology
ovarian cancer staging
Human
Retroperitoneal
Lymph node
Stage classification
Cytology
Peritoneal cavity
Intraoperative
Malignant tumor
Female genital diseases
Pathology
Ovarian diseases
Ovary
Sensitivity
Specificity
Histopathology
Female
Diagnosis
Technique
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Summary:Objective. The goal of this work was to evaluate the use of intraoperative cytology in the improvement of ovarian cancer staging. Methods. Fifty-two patients with clinical stage IA–IIB ovarian cancer underwent peritoneal washing (PW) cytology and imprint cytology performed on retroperitoneal lymph node samples, during primary surgical treatment. Cytologic specimens were stained by the May–Grünwald–Giemsa (MGG) and hematoxylin–eosin (HE) techniques. Pertinent histologic sections of the ovarian lesions, cell blocks prepared from PW sediments, and lymph node samples were studied and compared with the cytologic findings. Results. Our study reveals that, when malignant cells are present in the peritoneal cavity, PW cytology has 84.6% sensitivity and 94.7% specificity in detecting them. Imprint cytology performed on lymph node samples presented 94.1% sensitivity and 94.1% specificity in the diagnosis of retroperitoneal metastasis of ovarian cancer. Only 7 patients (13.4%) were upstaged with either cytologic method. PW cytology alone upstaged 6 more patients, while imprint cytology alone upstaged 11 more patients. This corresponds to a total of 17 patients (32.6%) who benefit from the combined performance of both cytologic methods. HE stain presents lower values of sensitivity and specificity compared with MGG. Conclusion. Cytologic evaluation of intraperitoneal and retroperitoneal spread of ovarian cancer by use of PW cytology and imprint cytology performed on lymph node samples contributes to the improvement of ovarian cancer staging.
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ISSN:0090-8258
1095-6859
DOI:10.1006/gyno.2002.6626