Search Results - "Romanic, A M"

Myocardial protection from ischemia/reperfusion injury by targeted deletion of matrix metalloproteinase-9 by Romanic, Anne M., Harrison, Stephen M., Bao, Weike, Burns-Kurtis, Cynthia L., Pickering, Susan, Gu, Juanli, Grau, Evelyn, Mao, Joyce, Sathe, Ganesh M., Ohlstein, Eliot H., Yue, Tian-Li

“…Abstract Objective: Matrix metalloproteinase-9 (MMP-9) activity is up regulated in the heart subjected to ischemic insult. Whether increased MMP-9 activity…”
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Possible Involvement of Stress-Activated Protein Kinase Signaling Pathway and Fas Receptor Expression in Prevention of Ischemia/Reperfusion-Induced Cardiomyocyte Apoptosis by Carvedilol by Yue, Tian-Li, Ma, Xin-Liang, Wang, Xinkang, Romanic, Anne M, Liu, Gao-lin, Louden, Calvert, Gu, Juan-Li, Kumar, Sanjay, Poste, George, Ruffolo, Robert R, Feuerstein, Giora Z

“…Carvedilol, a new vasodilating beta-adrenoceptor antagonist and a potent antioxidant, produces a high degree of cardioprotection in a variety of experimental…”
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The Induction of 72-kD Gelatinase in T Cells upon Adhesion to Endothelial Cells Is VCAM-1 Dependent by Romanic, Anne M., Madri, Joseph A.

“…T cell extravasation from the bloodstream into the perivascular tissue during inflammation involves transmigration through the endothelial cell layer and…”
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Upregulated expression of human membrane type-5 matrix metalloproteinase in kidneys from diabetic patients by Romanic, A M, Burns-Kurtis, C L, Ao, Z, Arleth, A J, Ohlstein, E H

“…Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade the extracellular matrix (ECM). The membrane-type matrix metalloproteinases…”
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Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 by Ames, Robert S, Sarau, Henry M, Chambers, Johathan K, Willette, Robert N, Aiyar, Nambi V, Romanic, Anne M, Louden, Calvert S, Foley, James J, Sauermelch, Charles F, Coatney, Robert W, Ao, Zhaohui, Disa, Jyoti, Holmes, Stephen D, Stadel, Jeffrey M, Martin, John D, Liu, Wu-Schyong, Glover, George I, Wilson, Shelagh, McNulty, Dean E, Ellis, Catherine E, Elshourbagy, Nabil A, Shabon, Usman, Trill, John J, Hay, Douglas W. P, Ohlstein, Eliot H, Bergsma, Derk J, Douglas, Stephen A

“…Urotensin-II (U-II) is a vasoactive 'somatostatin-like' cyclic peptide which was originally isolated from fish spinal cords, and which has recently been cloned…”
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Copolymerization of pNcollagen III and collagen I. pNcollagen III decreases the rate of incorporation of collagen I into fibrils, the amount of collagen I incorporated, and the diameter of the fibrils formed by ROMANIC, A. M, ADACHI, E, KADLER, K. E, HOJIMA, Y, PROCKOP, D. J

“…Previous observations suggested that pNcollagen III, the partially processed form of type III procollagen, coats fibrils of collagen I and thereby helps…”
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A mutation in the gene for type III procollagen (COL3A1) in a family with aortic aneurysms by KONTUSAARI, S, TROMP, G, KUIVANIEMI, H, ROMANIC, A. M, PROCKOP, D. J

“…Experiments were carried out to test the hypothesis that familial aortic aneurysms, either thoracic or abdominal, are caused by mutations in the gene for type…”
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Factor XIIIa Cross-links Lipoprotein(a) With Fibrinogen and Is Present in Human Atherosclerotic Lesions by Romanic, Anne M, Arleth, Anthony J, Willette, Robert N, Ohlstein, Eliot H

“…During the development of atherosclerotic lesions, lipoprotein(a) [Lp(a)], a highly atherogenic lipoprotein, accumulates within fibrin clots attached to blood…”
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Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size by Romanic, A M, White, R F, Arleth, A J, Ohlstein, E H, Barone, F C

“…Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade the extracellular matrix and are implicated in numerous pathological…”
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Activation of peroxisome proliferator-activated receptor-α protects the heart from ischemia/reperfusion injury by YUE, Tian-Li, WEIKE BAO, MIRABILE, Rosanna C, ARAVINDHAN, Karpagam, OHLSTEIN, Eliot H, JUCKER, Beat M, GU, Juan-Li, ROMANIC, Anne M, BROWN, Peter J, JIANQI CUI, THUDIUM, Douglas T, BOYCE, Rogely, BURNS-KURTIS, Cynthia L

“…Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) is expressed in the heart and regulates genes involved in myocardial fatty acid oxidation (FAO)…”
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T cell adhesion to endothelial cells and extracellular matrix is modulated upon transendothelial cell migration by Romanic, A M, Graesser, D, Baron, J L, Visintin, I, Janeway, Jr, C A, Madri, J A

“…During inflammation, T cells transmigrate from the bloodstream into perivascular tissues. As T cells transmigrate, they undergo a series of attachments to and…”
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SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung by Underwood, D C, Osborn, R R, Bochnowicz, S, Webb, E F, Rieman, D J, Lee, J C, Romanic, A M, Adams, J L, Hay, D W, Griswold, D E

“…The effects of a second generation p38 mitogen-activated protein kinase (MAPK) inhibitor, SB 239063…”
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Characterization of type I procollagen N-proteinase from fetal bovine tendon and skin. Purification of the 500-kilodalton form of the enzyme from bovine tendon by Hojima, Y, Mörgelin, M M, Engel, J, Boutillon, M M, van der Rest, M, McKenzie, J, Chen, G C, Rafi, N, Romanic, A M, Prockop, D J

“…Procollagen N-proteinase (EC 3.4.24.14) is the enzyme that specifically cleaves the NH2-terminal propeptides from type I procollagen. Two forms of N-proteinase…”
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Matrix metalloproteinase expression in cardiac myocytes following myocardial infarction in the rabbit by Romanic, Anne M., Burns-Kurtis, Cynthia L., Gout, Bernard, Berrebi-Bertrand, Isabelle, Ohlstein, Eliot H.

“…Myocardial infarction (MI), leads to cardiac remodeling, thinning of the ventricle wall, ventricular dilation, and heart failure, and is a leading cause of…”
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Polymerization of pNcollagen I and copolymerization of pNcollagen I with collagen I. A kinetic, thermodynamic, and morphologic study by Romanic, A M, Adachi, E, Hojima, Y, Engel, J, Prockop, D J

“…Previous observations established that pNcollagen III copolymerized with collagen I and decreased the diameter of the fibrils formed (Romanic, A.M., Adachi,…”
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Extracellular matrix-degrading proteinases in the nervous system by Romanic, A M, Madri, J A

“…The proteolytic activities of matrix metalloproteinases and plasminogen activators as well as their inhibitors are important in maintaining the integrity of…”
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Staurosporine-induced Apoptosis in Cardiomyocytes: A Potential Role of Caspase-3 by Yue, Tian-Li, Wang, Chuanlin, Romanic, Anne M, Kikly, Kristine, Keller, Paul, DeWolf Jr, Watler E, Hart, Timothy K, Thomas, Heath C, Storer, Barbara, Gu, Juan-Li, Wang, Xinkang, Feuerstein, Giora Z

“…Cardiomyocyte apoptosis has been demonstrated in animal models of cardiac injury as well as in patients with congestive heart failure or acute myocardial…”
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Metalloproteinase increases in the injured rat spinal cord by de Castro, Romulo, Burns, Cynthia L, McAdoo, David J, Romanic, Anne M

“…Up-regulation of matrix metalloproteinases MMP-9 and MMP-2 after injury to the spinal cord (SCI) is demonstrated. MMP-9 activity maximized at 12–24 h, and…”
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TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) and caspase-3-like protease by Yue, T L, Ni, J, Romanic, A M, Gu, J L, Keller, P, Wang, C, Kumar, S, Yu, G L, Hart, T K, Wang, X, Xia, Z, DeWolf, Jr, W E, Feuerstein, G Z

“…TL1 is a recently discovered novel member of the tumor necrosis factor (TNF) cytokine family. TL1 is abundantly expressed in endothelial cells, but its…”
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Self-assembly of collagen I from a proband homozygous for a mutation that substituted serine for glycine at position 661 in the alpha 2(I) chain. Possible relationship between the effects of mutations on critical concentration and the severity of the phenotype by Romanic, A M, Spotila, L D, Adachi, E, Engel, J, Hojima, Y, Prockop, D J

“…Procollagen I was isolated from cultured skin fibroblasts from a proband who was homozygous for a mutation in the COL1A2 gene that substituted a serine codon…”
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