Search Results - "Romanha, Alvaro José"

In vitro and in vivo experimental models for drug screening and development for Chagas disease by Romanha, Alvaro José, de Castro, Solange Lisboa, Soeiro, Maria de Nazaré Correia, Lannes-Vieira, Joseli, Ribeiro, Isabela, Talvani, André, Bourdin, Bernadette, Blum, Bethania, Olivieri, Bianca, Zani, Carlos, Spadafora, Carmenza, Chiari, Egler, Chatelain, Eric, Chaves, Gabriela, Calzada, José Eduardo, Bustamante, Juan Manuel, Freitas-Junior, Lucio H, Romero, Luz I, Bahia, Maria Terezinha, Lotrowska, Michel, Soares, Milena, Andrade, Sonia Gumes, Armstrong, Tanya, Degrave, Wim, Andrade, Zilton de Araújo

“…Chagas disease, a neglected illness, affects nearly 12-14 million people in endemic areas of Latin America. Although the occurrence of acute cases sharply has…”
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Arylimidamide DB766, a Potential Chemotherapeutic Candidate for Chagas' Disease Treatment by DA GAMA JAEN BATISTA, Denise, MEUSER BATISTA, Marcos, STEPHENS, Chad E, BOYKIN, David W, CORREIA SOEIRO, Maria De Nazaré, MELO DE OLIVEIRA, Gabriel, BORGES DO AMARAL, Patricia, LANNES-VIEIRA, Joseli, CARVALHO BRITTO, Constanca, JUNQUEIRA, Angela, LIMA, Marli Maria, ROMANHA, Alvaro José, SALES JUNIOR, Policarpo Ademar

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Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole by Téllez, Jair, Romero, Ibeth, Romanha, Alvaro José, Steindel, Mario

“…Chagas disease is a potentially life-threatening disease caused by the protozoan parasite Trypanosoma cruzi. Current therapeutic management is limited to…”
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Transsulfuration is an active pathway for cysteine biosynthesis in Trypanosoma rangeli by Romero, Ibeth, Téllez, Jair, Eiko Yamanaka, Lais, Steindel, Mario, José Romanha, Alvaro, Carlos Grisard, Edmundo

“…BACKGROUND: Cysteine, a sulfur-containing amino acid, plays an important role in a variety of cellular functions such as protein biosynthesis, methylation, and…”
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Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations by Moreira, Douglas de Souza, Duarte, Ana Paula, Pais, Fabiano Sviatopolk Mirsky, Silva-Pereira, Rosiane Aparecida da, Romanha, Alvaro José, Schenkman, Sergio, Murta, Silvane Maria Fonseca

“…Eukaryotic initiation factor 5A (eIF5A) is a conserved protein with an essential role in translation elongation. Using one and two-dimensional western…”
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Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp by Campos, Fernanda Fraga, Junior, Policarpo A. Sales, Romanha, Alvaro José, Araújo, Márcio S.S, Siqueira, Ezequias P, Resende, Jarbas M, Alves, Tânia M.A, Martins-Filho, Olindo A, dos Santos, Vera Lúcia, Rosa, Carlos A, Zani, Carlos L, Cota, Betania Barros

“…Aiming to identify new sources of bioactive secondary metabolites, we isolated 82 endophytic fungi from stems and barks of the native Brazilian tree…”
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Synthesis of Xylitan Derivatives and Preliminary Evaluation of in Vitro Trypanocidal Activity by Elias, Paula Regina, Coelho, Gleicekelly Silva, Xavier, Viviane Flores, Sales Junior, Policarpo Ademar, Romanha, Alvaro José, Murta, Silvane Maria Fonseca, Carneiro, Claudia Martins, Camilo, Nilton Soares, Hilário, Flaviane Francisco, Taylor, Jason Guy

“…A series of novel xylitan derivatives derived from xylitol were synthesized using operationally simple procedures. A xylitan acetonide was the key intermediate…”
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The in vitro leishmanicidal activity of hexadecylphosphocholine (miltefosine) against four medically relevant Leishmania species of Brazil by de Morais-Teixeira, Eliane, Damasceno, Quesia Souza, Galuppo, Mariana Kolos, Romanha, Alvaro José, Rabello, Ana

“…The in vitro leishmanicidal activity of miltefosine® (Zentaris GmbH) was assessed against four medically relevant Leishmania species of Brazil: Leishmania…”
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In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures by Lavorato, Stefânia Neiva, Júnior, Policarpo Ademar Sales, Murta, Silvane Maria Fonseca, Romanha, Alvaro José, Alves, Ricardo José

“…We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were…”
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The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms by Júnior, Policarpo Ademar Sales, Júnior, Celso Oliveira Rezende, Le Hyaric, Mireille, de Almeida, Mauro Vieira, Romanha, Alvaro José

“…Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of…”
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The level of ascorbate peroxidase is enhanced in benznidazole-resistant populations of Trypanosoma cruzi and its expression is modulated by stress generated by hydrogen peroxide by Nogueira, Fernanda Barbosa, Rodrigues, Joyce Fernanda A, Correa, Marcos Messias S, Ruiz, Jerônimo Conceição, Romanha, Alvaro José, Murta, Silvane Maria Fonseca

“…Ascorbate peroxidases (APX) are class I heme-containing enzymes that convert hydrogen peroxide into water molecules. The gene encoding APX has been…”
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In vitro trypanocidal activity of DB745B and other novel arylimidamides against Trypanosoma cruzi by FRANCA DA SILVA, Cristiane, JUNQUEIRA, Angela, LIMA, Marli Maria, JOSE ROMANHA, Alvaro, ADEMAR SALES JUNIOR, Policarpo, STEPHENS, Chad E, SOM, Phanneth, BOYKIN, David W, DE NAZARE CORREIA SOEIRO, Maria

“…As part of a search for new therapeutic opportunities to treat chagasic patients, in vitro efficacy studies were performed to characterize the activity of five…”
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The activity of a metronidazole analogue and its β-cyclodextrin complex against Trypanosoma cruzi by Lopes, Marcela Silva, Sales Júnior, Policarpo Ademar, Lopes, Amanda Gervásio Ferreira, Yoshida, Maria Irene, Silva, Thais Horta Alvares da, Romanha, Alvaro José, Alves, Ricardo José, Oliveira, Renata Barbosa de

“…In this study we prepared an inclusion complex between an iodide analogue of metronidazole (MTZ-I) and cyclodextrin (CD) to develop a safer and more effective…”
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Upregulation of Cysteine Synthase and Cystathionine β-Synthase Contributes to Leishmania braziliensis Survival under Oxidative Stress by Romero, Ibeth, Téllez, Jair, Romanha, Alvaro José, Steindel, Mario, Grisard, Edmundo Carlos

“…Cysteine metabolism is considered essential for the crucial maintenance of a reducing environment in trypanosomatids due to its importance as a precursor of…”
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A potent trypanocidal component from the fungus Lentinus strigosus inhibits trypanothione reductase and modulates PBMC proliferation by Cota, Betania Barros, Rosa, Luiz Henrique, Fagundes, Elaine Maria Souza, Martins-Filho, Olindo Assis, Correa-Oliveira, Rodrigo, Romanha, Alvaro José, Rosa, Carlos Augusto, Zani, Carlos Leomar

“…The fungus Lentinus strigosus (Pegler 1983) (Polyporaceae, basidiomycete) was selected in a screen for inhibitory activity on Trypanosoma cruzi trypanothione…”
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Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification by Braga, Saulo Fehelberg Pinto, Martins, Luan Carvalho, da Silva, Elany Barbosa, Sales Júnior, Policarpo Ademar, Murta, Silvane Maria Fonseca, Romanha, Alvaro José, Soh, Wai Tuck, Brandstetter, Hans, Ferreira, Rafaela Salgado, de Oliveira, Renata Barbosa

“…[Display omitted] Analogues of 8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]indol-4-amine 1, a known cruzain inhibitor, were synthesized using a molecular…”
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Knockdown of Host Antioxidant Defense Genes Enhances the Effect of Glucantime on Intracellular Leishmania braziliensis in Human Macrophages by Téllez, Jair, Romero, Ibeth, Soares, Maurilio José, Steindel, Mario, Romanha, Alvaro José

“…Leishmaniasis is a neglected tropical disease that affects millions of people worldwide and represents a major public health problem. Information on protein…”
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The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice by Miguel, Danilo Ciccone, Ferraz, Marcela Lencine, de Oliveira Alves, Rosana, Yokoyama-Yasunaka, Jenicer K.U, Torrecilhas, Ana Claudia, Romanha, Alvaro José, Uliana, Silvia R.B

“…The activity of the antineoplastic drug tamoxifen was evaluated against Trypanosoma cruzi . In vitro activity was determined against epimastigote,…”
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Susceptibility of Triatoma infestans to deltamethrin in Rio Grande do Sul, Brazil by Sonoda, Ivan Vieira, Pessoa, Grasiele Caldas D'Ávila, Cortez, Mirko Rojas, Dias, João Carlos Pinto, Romanha, Alvaro José, Diotaiuti, Liléia

“…Strategies for controlling Chagas disease are based on spraying infested houses with pyrethroid insecticides. However, the intense use of these insecticides…”
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Susceptibility of Triatoma brasiliensis from state of Ceará, Northeastern Brazil, to the pyrethroid deltamethrin by Sonoda, Ivan Vieira, Dias, Letícia Sena, Bezerra, Cláudia Mendonça, Dias, João Carlos Pinto, Romanha, Alvaro José, Diotaiuti, Liléia

“…After controlling Triatoma infestans in Brazil, other species of triatomine that were considered minor in the transmission of Chagas disease became important…”
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