Peroxiredoxins in erythrocytes: far beyond the antioxidant role

Peroxiredoxins in erythrocytes: far beyond the antioxidant role

The red blood cells (RBCs) are essential to transport oxygen (O 2 ) and nutrients throughout the human body. Changes in the structure or functioning of the erythrocytes can lead to several deficiencies, such as hemolytic anemias, in which an increase in reactive oxidative species generation is invol...

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Published in:Journal of molecular medicine (Berlin, Germany) Vol. 101; no. 11; pp. 1335 - 1353
Main Authors: de Paula, Carla Peres, de Oliveira da Silva, João Pedro Maia, Romanello, Karen Simone, Bernardo, Victoria Simões, Torres, Flaviene Felix, da Silva, Danilo Grünig Humberto, da Cunha, Anderson Ferreira
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-11-2023
Springer Nature B.V
Subjects:
Antioxidants
Antioxidants - metabolism
Biomedical and Life Sciences
Biomedicine
Erythrocytes
Erythrocytes - metabolism
Hemolysis
Hemolytic anemia
Homeostasis
Human Genetics
Humans
Hydrogen Peroxide
Internal Medicine
Isoforms
Molecular Medicine
Oxidation-Reduction
Oxidative Stress
Oxygen
Peroxiredoxin
Peroxiredoxins - chemistry
Peroxiredoxins - metabolism
Review
Hemolytic anemias
Oxidative stress
Red blood cells
Redox biology
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Summary:The red blood cells (RBCs) are essential to transport oxygen (O 2 ) and nutrients throughout the human body. Changes in the structure or functioning of the erythrocytes can lead to several deficiencies, such as hemolytic anemias, in which an increase in reactive oxidative species generation is involved in the pathophysiological process, playing a significant role in the severity of several clinical manifestations. There are important lines of defense against the damage caused by oxidizing molecules. Among the antioxidant molecules, the enzyme peroxiredoxin (Prx) has the higher decomposition power of hydrogen peroxide, especially in RBCs, standing out because of its abundance. This review aimed to present the recent findings that broke some paradigms regarding the three isoforms of Prxs found in RBC (Prx1, Prx2, and Prx6), showing that in addition to their antioxidant activity, these enzymes may have supplementary roles in transducing peroxide signals, as molecular chaperones, protecting from membrane damage, and maintenance of iron homeostasis, thus contributing to the overall survival of human RBCs, roles that seen to be disrupted in hemolytic anemia conditions.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:0946-2716
1432-1440
DOI:10.1007/s00109-023-02368-7