Search Results - "Romanelli, Maria Novella"

The Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: from Biophysics to Pharmacology of a Unique Family of Ion Channels by Sartiani, Laura, Mannaioni, Guido, Masi, Alessio, Novella Romanelli, Maria, Cerbai, Elisabetta

“…Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels are important members of the voltage-gated pore loop channels family. They show unique…”
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HCN Channels Modulators: The Need for Selectivity by Novella Romanelli, Maria, Sartiani, Laura, Masi, Alessio, Mannaioni, Guido, Manetti, Dina, Mugelli, Alessandro, Cerbai, Elisabetta

“…Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, the molecular correlate of the hyperpolarization-activated current (If/Ih), are membrane…”
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Synthetic Approaches to Piperazine-Containing Drugs Approved by FDA in the Period of 2011-2023 by Romanelli, Maria Novella, Braconi, Laura, Gabellini, Alessio, Manetti, Dina, Marotta, Giambattista, Teodori, Elisabetta

“…The piperazine moiety is often found in drugs or in bioactive molecules. This widespread presence is due to different possible roles depending on the position…”
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The new HDAC1 inhibitor LG325 ameliorates neuropathic pain in a mouse model by Sanna, Maria Domenica, Guandalini, Luca, Romanelli, Maria Novella, Galeotti, Nicoletta

“…Current analgesic therapies for treatment of neuropathic pain are unsatisfactory. Neuropathic pain is, therefore, undertreated and there is a significant need…”
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Hyperpolarization-activated cyclic-nucleotide-gated channels: pathophysiological, developmental, and pharmacological insights into their function in cellular excitability by Spinelli, Valentina, Sartiani, Laura, Mugelli, Alessandro, Romanelli, Maria Novella, Cerbai, Elisabetta

“…The hyperpolarization-activated cyclic-nucleotide-gated (HCN) proteins are voltage-dependent ion channels, conducting both Na and K , blocked by millimolar…”
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Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators by Manetti, Dina, Dei, Silvia, Arias, Hugo R, Braconi, Laura, Gabellini, Alessio, Teodori, Elisabetta, Romanelli, Maria Novella

“…Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent agonists, allosteric activating PAMs and neutral or silent allosteric…”
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Overcoming Multidrug Resistance (MDR): Design, Biological Evaluation and Molecular Modelling Studies of 2,4‐Substituted Quinazoline Derivatives by Braconi, Laura, Teodori, Elisabetta, Contino, Marialessandra, Riganti, Chiara, Bartolucci, Gianluca, Manetti, Dina, Romanelli, Maria Novella, Perrone, Maria Grazia, Colabufo, Nicola Antonio, Guglielmo, Stefano, Dei, Silvia

“…Some 2,4‐disubstituted quinazolines were synthesized and studied as multidrug resistance (MDR) reversers. The new derivatives carried the quinazoline‐4‐amine…”
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The Tetrahydroisoquinoline Scaffold in ABC Transporter Inhibitors that Act as Multidrug Resistance (MDR) Reversers by Teodori, Elisabetta, Braconi, Laura, Manetti, Dina, Romanelli, Maria Novella, Dei, Silvia

“…The failure of anticancer chemotherapy is often due to the development of resistance to a variety of anticancer drugs. This phenomenon is called multidrug…”
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The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System by Zobeiri, Mehrnoush, Chaudhary, Rahul, Blaich, Anne, Rottmann, Matthias, Herrmann, Stefan, Meuth, Patrick, Bista, Pawan, Kanyshkova, Tatyana, Lüttjohann, Annika, Narayanan, Venu, Hundehege, Petra, Meuth, Sven G, Romanelli, Maria Novella, Urbano, Francisco J, Pape, Hans-Christian, Budde, Thomas, Ludwig, Andreas

“…Abstract Hyperpolarization-activated cation channels are involved, among other functions, in learning and memory, control of synaptic transmission and…”
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Dual P-Glycoprotein and CA XII Inhibitors: A New Strategy to Reverse the P-gp Mediated Multidrug Resistance (MDR) in Cancer Cells by Teodori, Elisabetta, Braconi, Laura, Bua, Silvia, Lapucci, Andrea, Bartolucci, Gianluca, Manetti, Dina, Romanelli, Maria Novella, Dei, Silvia, Supuran, Claudiu T, Coronnello, Marcella

“…A new series of -bis(alkanol)amine aryl diesters was synthesized and studied as dual P-glycoprotein (P-gp) and carbonic anhydrase XII inhibitors (CA XII)…”
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Dual Inhibitors of P-gp and Carbonic Anhydrase XII (hCA XII) against Tumor Multidrug Resistance with Piperazine Scaffold by Braconi, Laura, Riganti, Chiara, Parenti, Astrid, Cecchi, Marta, Nocentini, Alessio, Bartolucci, Gianluca, Menicatti, Marta, Contino, Marialessandra, Colabufo, Nicola Antonio, Manetti, Dina, Romanelli, Maria Novella, Supuran, Claudiu T, Teodori, Elisabetta

“…A new series of piperazine derivatives were synthesized and studied with the aim of obtaining dual inhibitors of P-glycoprotein (P-gp) and carbonic anhydrase…”
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Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation by Arias, Hugo R., Micheli, Laura, Rudin, Deborah, Bento, Ophelie, Borsdorf, Saskia, Ciampi, Clara, Marin, Philippe, Ponimaskin, Evgeni, Manetti, Dina, Romanelli, Maria Novella, Ghelardini, Carla, Liechti, Matthias E., Di Cesare Mannelli, Lorenzo

“…The aim of this study was to determine the anti-hypersensitivity activity of novel non-hallucinogenic compounds derived from iboga alkaloids (i.e., ibogalogs),…”
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New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators by Chiaramonte, Niccolò, Gabellini, Alessio, Angeli, Andrea, Bartolucci, Gianluca, Braconi, Laura, Dei, Silvia, Teodori, Elisabetta, Supuran, Claudiu T, Romanelli, Maria Novella

“…A series of histamine (HST)-related compounds were synthesized and tested for their activating properties on five physiologically relevant human Carbonic…”
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Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain by Dini, Leonardo, Del Lungo, Martina, Resta, Francesco, Melchiorre, Michele, Spinelli, Valentina, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Laurino, Annunziatina, Sartiani, Laura, Coppini, Raffaele, Mannaioni, Guido, Cerbai, Elisabetta, Romanelli, Maria Novella

“…A prominent role of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels has been suggested based on their expression and (dys)function in…”
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A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer by Ruzzolini, Jessica, Laurenzana, Anna, Andreucci, Elena, Peppicelli, Silvia, Bianchini, Francesca, Carta, Fabrizio, Supuran, Claudiu T., Romanelli, Maria Novella, Nediani, Chiara, Calorini, Lido

“…The emergence of tumour recurrence and resistance limits the survival rate for most tumour-bearing patients. Only, combination therapies targeting pathways…”
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Updates on HCN Channels in the Heart: Function, Dysfunction and Pharmacology by Sartiani, Laura, Romanelli, Maria Novella, Mugelli, Alessandro, Cerbai, Elisabetta

“…The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play an important role in the generation of pacemaker activity of cardiac sinoatrial…”
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Two types of interneurons in the mouse lateral geniculate nucleus are characterized by different h-current density by Leist, Michael, Datunashvilli, Maia, Kanyshkova, Tatyana, Zobeiri, Mehrnoush, Aissaoui, Ania, Cerina, Manuela, Romanelli, Maria Novella, Pape, Hans-Christian, Budde, Thomas

“…Although hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels and the corresponding h-current ( I h ) have been shown to fundamentally…”
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Effectiveness of the histone deacetylase inhibitor (S)-2 against LNCaP and PC3 human prostate cancer cells by Laurenzana, Anna, Balliu, Manjola, Cellai, Cristina, Romanelli, Maria Novella, Paoletti, Francesco

“…Histone deacetylase inhibitors (HDACi) represent a promising class of epigenetic agents with anticancer properties. Here, we report that (S)-2, a novel…”
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(E)‑3-Furan-2-yl‑N‑p‑tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation by Arias, Hugo R, Ghelardini, Carla, Lucarini, Elena, Tae, Han-Shen, Yousuf, Arsalan, Marcovich, Irina, Manetti, Dina, Romanelli, Maria Novella, Elgoyhen, Ana Belén, Adams, David J, Di Cesare Mannelli, Lorenzo

“…The main objective of this study was to determine whether (E)-3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2) and its structural derivative DM489 produce…”
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6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers by Braconi, Laura, Bartolucci, Gianluca, Contino, Marialessandra, Chiaramonte, Niccolò, Giampietro, Roberta, Manetti, Dina, Perrone, Maria Grazia, Romanelli, Maria Novella, Colabufo, Nicola Antonio, Riganti, Chiara, Dei, Silvia, Teodori, Elisabetta

“…Aiming to deepen the structure-activity relationships of the two P-glycoprotein (P-gp) modulators elacridar and tariquidar, a new series of amide and ester…”
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