Search Results - "Romanel, Alessandro"

A highly specific SpCas9 variant is identified by in vivo screening in yeast by Casini, Antonio, Olivieri, Michele, Petris, Gianluca, Montagna, Claudia, Reginato, Giordano, Maule, Giulia, Lorenzin, Francesca, Prandi, Davide, Romanel, Alessandro, Demichelis, Francesca, Inga, Alberto, Cereseto, Anna

“…Evolved SpCas9 variant evoCas9 has improved specificity and retains near wild-type on-target activity. Despite the utility of CRISPR–Cas9 nucleases for genome…”
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Correction: PaCBAM: fast and scalable processing of whole exome and targeted sequencing data by Valentini, Samuel, Fedrizzi, Tarcisio, Demichelis, Francesca, Romanel, Alessandro

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EthSEQ: ethnicity annotation from whole exome sequencing data by Romanel, Alessandro, Zhang, Tuo, Elemento, Olivier, Demichelis, Francesca

“…Whole exome sequencing (WES) is widely utilized both in translational cancer genomics studies and in the setting of precision medicine. Stratification of…”
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Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer by Beltran, Himisha, Romanel, Alessandro, Conteduca, Vincenza, Casiraghi, Nicola, Sigouros, Michael, Franceschini, Gian Marco, Orlando, Francesco, Fedrizzi, Tarcisio, Ku, Sheng-Yu, Dann, Emma, Alonso, Alicia, Mosquera, Juan Miguel, Sboner, Andrea, Xiang, Jenny, Elemento, Olivier, Nanus, David M, Tagawa, Scott T, Benelli, Matteo, Demichelis, Francesca

“…Loss of androgen receptor (AR) signaling dependence occurs in approximately 15%-20% of advanced treatment-resistant prostate cancers, and this may manifest…”
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PaCBAM: fast and scalable processing of whole exome and targeted sequencing data by Valentini, Samuel, Fedrizzi, Tarcisio, Demichelis, Francesca, Romanel, Alessandro

“…Interrogation of whole exome and targeted sequencing NGS data is rapidly becoming a preferred approach for the exploration of large cohorts in the research…”
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Hit and go CAS9 delivered through a lentiviral based self-limiting circuit by Petris, Gianluca, Casini, Antonio, Montagna, Claudia, Lorenzin, Francesca, Prandi, Davide, Romanel, Alessandro, Zasso, Jacopo, Conti, Luciano, Demichelis, Francesca, Cereseto, Anna

“…In vivo application of the CRISPR-Cas9 technology is still limited by unwanted Cas9 genomic cleavages. Long-term expression of Cas9 increases the number of…”
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Integrative multiplatform molecular profiling of benign prostatic hyperplasia identifies distinct subtypes by Liu, Deli, Shoag, Jonathan E., Poliak, Daniel, Goueli, Ramy S., Ravikumar, Vaishali, Redmond, David, Vosoughi, Aram, Fontugne, Jacqueline, Pan, Heng, Lee, Daniel, Thomas, Domonique, Salari, Keyan, Wang, Zongwei, Romanel, Alessandro, Te, Alexis, Lee, Richard, Chughtai, Bilal, Olumi, Aria F., Mosquera, Juan Miguel, Demichelis, Francesca, Elemento, Olivier, Rubin, Mark A., Sboner, Andrea, Barbieri, Christopher E.

“…Benign prostatic hyperplasia (BPH), a nonmalignant enlargement of the prostate, is among the most common diseases affecting aging men, but the underlying…”
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Tumor clone dynamics in lethal prostate cancer by Carreira, Suzanne, Romanel, Alessandro, Goodall, Jane, Grist, Emily, Ferraldeschi, Roberta, Miranda, Susana, Prandi, Davide, Lorente, David, Frenel, Jean-Sebastien, Pezaro, Carmel, Omlin, Aurelius, Rodrigues, Daniel Nava, Flohr, Penelope, Tunariu, Nina, S de Bono, Johann, Demichelis, Francesca, Attard, Gerhardt

“…It is unclear whether a single clone metastasizes and remains dominant over the course of lethal prostate cancer. We describe the clonal architectural…”
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A slow-cycling/quiescent cells subpopulation is involved in glioma invasiveness by Antonica, Francesco, Santomaso, Lucia, Pernici, Davide, Petrucci, Linda, Aiello, Giuseppe, Cutarelli, Alessandro, Conti, Luciano, Romanel, Alessandro, Miele, Evelina, Tebaldi, Toma, Tiberi, Luca

“…Pediatric and adult high-grade gliomas are the most common primary malignant brain tumors, with poor prognosis due to recurrence and tumor infiltration after…”
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LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice by Prakasam, Ramachandran, Bonadiman, Angela, Andreotti, Roberta, Zuccaro, Emanuela, Dalfovo, Davide, Marchioretti, Caterina, Tripathy, Debasmita, Petris, Gianluca, Anderson, Eric N., Migazzi, Alice, Tosatto, Laura, Cereseto, Anna, Battaglioli, Elena, Sorarù, Gianni, Lim, Wooi Fang, Rinaldi, Carlo, Sambataro, Fabio, Pourshafie, Naemeh, Grunseich, Christopher, Romanel, Alessandro, Pandey, Udai Bhan, Contestabile, Andrea, Ronzitti, Giuseppe, Basso, Manuela, Pennuto, Maria

“…Spinobulbar muscular atrophy (SBMA) is caused by CAG expansions in the androgen receptor gene. Androgen binding to polyQ-expanded androgen receptor triggers…”
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RB1 Heterogeneity in Advanced Metastatic Castration-Resistant Prostate Cancer by Nava Rodrigues, Daniel, Casiraghi, Nicola, Romanel, Alessandro, Crespo, Mateus, Miranda, Susana, Rescigno, Pasquale, Figueiredo, Ines, Riisnaes, Ruth, Carreira, Suzanne, Sumanasuriya, Semini, Gasperini, Paola, Sharp, Adam, Mateo, Joaquin, Makay, Alan, McNair, Christopher, Schiewer, Matthew, Knudsen, Karen, Boysen, Gunther, Demichelis, Francesca, de Bono, Johann S

“…Metastatic castration-resistant prostate cancer (mCRPC) is a lethal but clinically heterogeneous disease, with patients having variable benefit from endocrine…”
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One-shot analysis of translated mammalian lncRNAs with AHARIBO by Minati, Luca, Firrito, Claudia, Del Piano, Alessia, Peretti, Alberto, Sidoli, Simone, Peroni, Daniele, Belli, Romina, Gandolfi, Francesco, Romanel, Alessandro, Bernabo, Paola, Zasso, Jacopo, Quattrone, Alessandro, Guella, Graziano, Lauria, Fabio, Viero, Gabriella, Clamer, Massimiliano

“…A vast portion of the mammalian genome is transcribed as long non-coding RNAs (lncRNAs) acting in the cytoplasm with largely unknown functions. Surprisingly,…”
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Plasma tumour DNA as an early indicator of treatment response in metastatic castration-resistant prostate cancer by Conteduca, Vincenza, Wetterskog, Daniel, Scarpi, Emanuela, Romanel, Alessandro, Gurioli, Giorgia, Jayaram, Anuradha, Lolli, Cristian, Tandefelt, Delila Gasi, Schepisi, Giuseppe, Casadei, Chiara, Wingate, Anna, Matteucci, Federica, Paganelli, Giovanni, Gonzalez-Billalabeitia, Enrique, Demichelis, Francesca, De Giorgi, Ugo, Attard, Gerhardt

“…ABSTRACT Background Plasma tumour DNA (ptDNA) levels on treatment are associated with response in a variety of cancers. However, the role of ptDNA in prostate…”
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Third generation EGFR inhibitor osimertinib combined with pemetrexed or cisplatin exerts long-lasting anti-tumor effect in EGFR-mutated pre-clinical models of NSCLC by La Monica, Silvia, Minari, Roberta, Cretella, Daniele, Flammini, Lisa, Fumarola, Claudia, Bonelli, Mara, Cavazzoni, Andrea, Digiacomo, Graziana, Galetti, Maricla, Madeddu, Denise, Falco, Angela, Lagrasta, Costanza Annamaria, Squadrilli, Anna, Barocelli, Elisabetta, Romanel, Alessandro, Quaini, Federico, Petronini, Pier Giorgio, Tiseo, Marcello, Alfieri, Roberta

“…The third generation Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) osimertinib has been initially approved for T790M positive…”
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Germline determinants of aberrant signaling pathways in cancer by Dalfovo, Davide, Scandino, Riccardo, Paoli, Marta, Valentini, Samuel, Romanel, Alessandro

“…Cancer is a complex disease influenced by a heterogeneous landscape of both germline genetic variants and somatic aberrations. While there is growing evidence…”
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Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma by Aiello, Giuseppe, Ballabio, Claudio, Ruggeri, Riccardo, Fagnocchi, Luca, Anderle, Marica, Morassut, Ilaria, Caron, Davide, Garilli, Francesca, Gianno, Francesca, Giangaspero, Felice, Piazza, Silvano, Romanel, Alessandro, Zippo, Alessio, Tiberi, Luca

“…The transition of neural progenitors to differentiated postmitotic neurons is mainly considered irreversible in physiological conditions. In the present work,…”
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Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and common HLA-B and TAP transcriptional silencing across advanced pediatric solid cancers by Lim, Wan Ching, Marques Da Costa, Maria Eugenia, Godefroy, Karine, Jacquet, Eric, Gragert, Loren, Rondof, Windy, Marchais, Antonin, Nhiri, Naima, Dalfovo, Davide, Viard, Mathias, Labaied, Nizar, Khan, Asif M, Dessen, Philippe, Romanel, Alessandro, Pasqualini, Claudia, Schleiermacher, Gudrun, Carrington, Mary, Zitvogel, Laurence, Scoazec, Jean-Yves, Geoerger, Birgit, Salmon, Jerome

“…The human leukocyte antigen (HLA) system is a major factor controlling cancer immunosurveillance and response to immunotherapy, yet its status in pediatric…”
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Inherited determinants of early recurrent somatic mutations in prostate cancer by Romanel, Alessandro, Garritano, Sonia, Stringa, Blerta, Blattner, Mirjam, Dalfovo, Davide, Chakravarty, Dimple, Soong, David, Cotter, Kellie A., Petris, Gianluca, Dhingra, Priyanka, Gasperini, Paola, Cereseto, Anna, Elemento, Olivier, Sboner, Andrea, Khurana, Ekta, Inga, Alberto, Rubin, Mark A., Demichelis, Francesca

“…Prostate cancer is a highly heritable molecularly and clinically heterogeneous disease. To discover germline events involved in prostate cancer predisposition,…”
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Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors by Alaimo, Alessandro, Lorenzoni, Marco, Ambrosino, Paolo, Bertossi, Arianna, Bisio, Alessandra, Macchia, Alice, Zoni, Eugenio, Genovesi, Sacha, Cambuli, Francesco, Foletto, Veronica, De Felice, Dario, Soldovieri, Maria Virginia, Mosca, Ilaria, Gandolfi, Francesco, Brunelli, Matteo, Petris, Gianluca, Cereseto, Anna, Villarroel, Alvaro, Thalmann, George, Carbone, Francesco Giuseppe, Kruithof-de Julio, Marianna, Barbareschi, Mattia, Romanel, Alessandro, Taglialatela, Maurizio, Lunardi, Andrea

“…Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic…”
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TranSNPs: A class of functional SNPs affecting mRNA translation potential revealed by fraction-based allelic imbalance by Valentini, Samuel, Marchioretti, Caterina, Bisio, Alessandra, Rossi, Annalisa, Zaccara, Sara, Romanel, Alessandro, Inga, Alberto

“…Few studies have explored the association between SNPs and alterations in mRNA translation potential. We developed an approach to identify SNPs that can mark…”
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