Search Results - "Roman, Richard J"

Effect of Cytochrome P450 Metabolites of Arachidonic Acid in Nephrology by Fan, Fan, Roman, Richard J

“…Thirty-five years ago, a third pathway for the metabolism of arachidonic acid by cytochrome P450 enzymes emerged. Subsequent work revealed that…”
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Cytochrome P450 eicosanoids in hypertension and renal disease by Fan, Fan, Muroya, Yoshikazu, Roman, Richard J

“…PURPOSE OF REVIEWCytochrome (CYP) P450 metabolites of arachidonic acid, 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs)…”
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P-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function by Roman, Richard J

“…Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin Roman, Richard J. P -450 Metabolites of Arachidonic Acid in the Control of…”
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Oxidative Stress and Renal Fibrosis: Recent Insights for the Development of Novel Therapeutic Strategies by Lv, Wenshan, Booz, George W, Fan, Fan, Wang, Yangang, Roman, Richard J

“…Chronic kidney disease (CKD) is a significant worldwide healthcare problem. Regardless of the initial injury, renal fibrosis is the common final pathway…”
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Astrocytes and the regulation of cerebral blood flow by Koehler, Raymond C, Roman, Richard J, Harder, David R

“…Moment-to-moment changes in local neuronal activity lead to dynamic changes in cerebral blood flow. Emerging evidence implicates astrocytes as one of the key…”
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Effects of a new SGLT2 inhibitor, luseogliflozin, on diabetic nephropathy in T2DN rats by Kojima, Naoki, Williams, Jan M, Takahashi, Teisuke, Miyata, Noriyuki, Roman, Richard J

“…This study examined the effect of long-term control of hyperglycemia with a new sodium glucose cotransporter 2 inhibitor, luseogliflozin, given alone or in…”
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Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction by He, Xiaochen, Zeng, Heng, Chen, Sean T., Roman, Richard J., Aschner, Judy L., Didion, Sean, Chen, Jian-Xiong

“…Endothelial glycolysis plays a critical role in the regulation of angiogenesis. We investigated the role of Sirtuin 3 (SIRT3) on endothelial cell (EC)…”
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Vascular contributions to cognitive impairment and dementia: the emerging role of 20-HETE by Gonzalez-Fernandez, Ezekiel, Liu, Yedan, Auchus, Alexander P, Fan, Fan, Roman, Richard J

“…The accumulation of extracellular amyloid-β (Aβ) and intracellular hyperphosphorylated τ proteins in the brain are the hallmarks of Alzheimer's disease (AD)…”
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DMOG, a Prolyl Hydroxylase Inhibitor, Increases Hemoglobin Levels without Exacerbating Hypertension and Renal Injury in Salt-Sensitive Hypertensive Rats by Kato, Sota, Takahashi, Teisuke, Miyata, Noriyuki, Roman, Richard J

“…Prolyl hydroxylase (PHD) inhibitors are being developed as alternatives to recombinant human erythropoietin (rHuEPO) for the treatment of anemia in patients…”
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Therapeutic potential of microRNAs for the treatment of renal fibrosis and CKD by Lv, Wenshan, Fan, Fan, Wang, Yangang, Gonzalez-Fernandez, Ezekiel, Wang, Chen, Yang, Lili, Booz, George W, Roman, Richard J

“…Chronic kidney disease (CKD), defined as reduced glomerular filtration rate, is increasingly becoming a major public health issue. At the histological level,…”
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Novel Mechanistic Insights and Potential Therapeutic Impact of TRPC6 in Neurovascular Coupling and Ischemic Stroke by Shekhar, Shashank, Liu, Yedan, Wang, Shaoxun, Zhang, Huawei, Fang, Xing, Zhang, Jin, Fan, Letao, Zheng, Baoying, Roman, Richard J, Wang, Zhen, Fan, Fan, Booz, George W

“…Ischemic stroke is one of the most disabling diseases and a leading cause of death globally. Despite advances in medical care, the global burden of stroke…”
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Enhanced renal ischemia-reperfusion injury in aging and diabetes by Muroya, Yoshikazu, He, Xiaochen, Fan, Letao, Wang, Shaoxun, Xu, Rui, Fan, Fan, Roman, Richard J

“…The incidence and severity of acute kidney injury is increased in patients with diabetes and with aging. However, the mechanisms involved have not been clearly…”
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Molecular mechanisms of renal blood flow autoregulation by Burke, Marilyn, Pabbidi, Mallikarjuna R, Farley, Jerry, Roman, Richard J

“…Diabetes and hypertension are the leading causes of chronic kidney disease and their incidence is increasing at an alarming rate. Both are associated with…”
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Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury by Zhang, Chao, He, Xiaochen, Murphy, Sydney R, Zhang, Huawei, Wang, Shaoxun, Ge, Ying, Gao, Wenjun, Williams, Jan M, Geurts, Aron M, Roman, Richard J, Fan, Fan

“…Dual-specificity protein phosphatase 5 (DUSP5) is a member of the tyrosine-threonine phosphatase family with the ability to dephosphorylate and inactivate…”
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Conflicting Roles of 20-HETE in Hypertension and Stroke by Shekhar, Shashank, Varghese, Kevin, Li, Man, Fan, Letao, Booz, George W, Roman, Richard J, Fan, Fan

“…Hypertension is the most common modifiable risk factor for stroke, and understanding the underlying mechanisms of hypertension and hypertension-related stroke…”
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Role of medullary blood flow in the pathogenesis of renal ischemia–reperfusion injury by Regner, Kevin R, Roman, Richard J

“…PURPOSE OF REVIEWRenal ischemia–reperfusion injury (IRI) is a common cause of acute kidney injury (AKI). Alterations in renal medullary blood flow (MBF)…”
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Eicosanoid Profiles in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy by Lin, Albert L, Roman, Richard J, Regan, Kathleen A, Bolch, Charlotte A, Chen, Ching-Jygh, Iyer, Siva S R

“…Proliferative diabetic retinopathy is a potentially blinding sequela of uncontrolled diabetes that involves a complex interaction of pro-angiogenic and…”
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Knockdown of Add3 impairs the myogenic response of renal afferent arterioles and middle cerebral arteries by Fan, Fan, Pabbidi, Mallikarjuna R, Ge, Ying, Li, Longyang, Wang, Shaoxun, Mims, Paige N, Roman, Richard J

“…We have reported that the myogenic response of the renal afferent arteriole (Af-art) and middle cerebral artery (MCA) and autoregulation of renal and cerebral…”
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20-Hydroxyeicosatetraenoic acid contributes to the inhibition of K+ channel activity and vasoconstrictor response to angiotensin II in rat renal microvessels by Fan, Fan, Sun, Cheng-Wen, Maier, Kristopher G, Williams, Jan M, Pabbidi, Malikarjuna R, Didion, Sean P, Falck, John R, Zhuo, Jialong, Roman, Richard J

“…The present study examined whether 20-hydroxyeicosatetraenoic acid (HETE) contributes to the vasoconstrictor effect of angiotensin II (ANG II) in renal…”
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Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats by Fan, Fan, Geurts, Aron M, Pabbidi, Mallikarjuna R, Smith, Stanley V, Harder, David R, Jacob, Howard, Roman, Richard J

“…We recently reported that the myogenic responses of the renal afferent arteriole (Af-Art) and middle cerebral artery (MCA) and autoregulation of renal and…”
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