Atrial fibrillation in patients with gastroesophageal reflux disease: A comprehensive review
AIM:To analyze the potential relationship between gastroesophageal reflux disease(GERD)and the development of atrial fibrillation(AF).METHODS:Using the key words"atrial fibrillation and gastroesophageal reflux","atrial fibrillation and esophagitis,peptic",&quo...
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| Published in: | World journal of gastroenterology : WJG Vol. 20; no. 28; pp. 9592 - 9599 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Baishideng Publishing Group Inc
28-07-2014
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | AIM:To analyze the potential relationship between gastroesophageal reflux disease(GERD)and the development of atrial fibrillation(AF).METHODS:Using the key words"atrial fibrillation and gastroesophageal reflux","atrial fibrillation and esophagitis,peptic","atrial fibrillation and hernia,hiatal"the PubMed,EMBASE,Cochrane Library,OVIDSP,WILEY databases were screened for relevant publications on GERD and AF in adults between January 1972-December 2013.Studies written in languages other than English or French,studies not performed in humans,reviews,case reports,abstracts,conference presentations,letters to the editor,editorials,comments and opinions were not taken into consideration.Articles treating the subject of radiofrequency ablation of AF and the consecutive development of GERD were also excluded.RESULTS:Two thousand one hundred sixty-one titles were found of which 8 articles met the inclusion criteria.The presence of AF in patients with GERD was reported to be between 0.62%-14%,higher compared to those without GERD.Epidemiological data provided by these observational studies showed that patients with GERD,especially those with more severe GERD-related symptoms,had an increased risk of developing AF compared with those without GERD,but a causal relationship between GERD and AF could not be established based on these studies.The mechanisms of AF as a consequence of GERD remain largely unknown,with inflammation and vagal stimulation playing a possible role in the development of these disorders.Treatment with proton pomp inhibitors may improve symptoms related to AF and facilitate conversion to sinus rhythm.CONCLUSION:Although links between AF and GERD exist,large randomized clinical studies are required for a better understanding of the relationship between these two entities. |
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| Bibliography: | Crina Roman;Stanislas Bruley des Varannes;Lucian Muresan;Alina Picos;Dan L Dumitrascu;Division of Internal Medicine,Second Medical Clinic,"Iuliu Hatieganu" University of Medicine and Pharmacy;Institut des Maladies de l’Appareil Digestif,University Hospital,Hotel Dieu,44093 Nantes Cedex 01,France;Department of Cardiology,Rehabilitation Hospital,"Iuliu Hatieganu" University of Medicine and Pharmacy;Faculty of Dentistry,"Iuliu Hatieganu" University of Medicine and Pharmacy Telephone: + 40-722-756475 Fax: +40-264-593355 Correspondence to: Dan L Dumitrascu, MD, Professor of Medicine, Division of Internal Medicine, Second Medical Clinic, “Iuliu Hatieganu” University of Medicine and Pharmacy, Clinicilor Street 4-6, 400006 Cluj-Napoca, Romania. dan_dumitrascu@yahoo.de Author contributions: Roman C designed and wrote the article; Bruley des Varannes S reviewed and corrected the manuscript; Muresan L contributed with suggestions and corrected the article; Picos A contributed with suggestions; Dumitrascu DL provided the idea of writing the article, contributed to the writing of the manuscript and is the guarantor of the work. |
| ISSN: | 1007-9327 2219-2840 |
| DOI: | 10.3748/wjg.v20.i28.9592 |