Search Results - "Roman, C."

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles by Eaton, John K., Furst, Laura, Ruberto, Richard A., Moosmayer, Dieter, Hilpmann, André, Ryan, Matthew J., Zimmermann, Katja, Cai, Luke L., Niehues, Michael, Badock, Volker, Kramm, Anneke, Chen, Sixun, Hillig, Roman C., Clemons, Paul A., Gradl, Stefan, Montagnon, Claire, Lazarski, Kiel E., Christian, Sven, Bajrami, Besnik, Neuhaus, Roland, Eheim, Ashley L., Viswanathan, Vasanthi S., Schreiber, Stuart L.

“…We recently described glutathione peroxidase 4 (GPX4) as a promising target for killing therapy-resistant cancer cells via ferroptosis. The onset of therapy…”
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Epigenetic Factors in Late-Onset Alzheimer's Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B Vitamins by Román, Gustavo C, Mancera-Páez, Oscar, Bernal, Camilo

“…DNA methylation and other epigenetic factors are important in the pathogenesis of late-onset Alzheimer's disease (LOAD). Methylenetetrahydrofolate reductase (…”
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Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides by Kapoor, Khyati, Finer-Moore, Janet S., Pedersen, Bjørn P., Caboni, Laura, Waight, Andrew, Hillig, Roman C., Bringmann, Peter, Heisler, Iring, Müller, Thomas, Siebeneicher, Holger, Stroud, Robert M.

“…Cancerous cells have an acutely increased demand for energy, leading to increased levels of human glucose transporter 1 (hGLUT1). This up-regulation suggests…”
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Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease by Román, G.C., Jackson, R.E., Gadhia, R., Román, A.N., Reis, J.

“…The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated…”
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Amphibian-killing chytrid in Brazil comprises both locally endemic and globally expanding populations by Jenkinson, T. S., Betancourt Román, C. M., Lambertini, C., Valencia-Aguilar, A., Rodriguez, D., Nunes-de-Almeida, C. H. L., Ruggeri, J., Belasen, A. M., da Silva Leite, D., Zamudio, K. R., Longcore, J. E., Toledo, L. F., James, T. Y.

“…Chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), is the emerging infectious disease implicated in recent population declines and…”
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Magmatic water content controls the pre-eruptive depth of arc magmas by Rasmussen, Daniel J, Plank, Terry A, Roman, Diana C, Zimmer, Mindy M

“…Vanguard efforts in forecasting volcanic eruptions are turning to physics-based models, which require quantitative estimates of magma conditions during…”
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Investigation on strategies for optimizing process definition in rubber processing: A study on mechanical and chemical properties of vulcanizates as basis for the development of a new calculation model for quality prediction by Traintinger, Martin, Kerschbaumer, Roman C., Hornbachner, Michaela, Lechner, Bernhard, Lucyshyn, Thomas

“…Rubber compounds may exhibit significant batch variations due to multiple different ingredients mixed in one compound. Hence, defining the manufacturing…”
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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction by Hillig, Roman C., Sautier, Brice, Schroeder, Jens, Moosmayer, Dieter, Hilpmann, André, Stegmanna, Christian M., Werbeck, Nicolas D., Briem, Hans, Boemer, Ulf, Weiske, Joerg, Badock, Volker, Mastouri, Julia, Petersen, Kirstin, Siemeister, Gerhard, Kahmann, Jan D., Wegener, Dennis, Böhnke, Niels, Eis, Knut, Graham, Keith, Wortmann, Lars, von Nussbaum, Franz, Bader, Benjamin

“…Since the late 1980s, mutations in the RAS genes have been recognized as major oncogenes with a high occurrence rate in human cancers. Such mutations reduce…”
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Sustained Co‐Eruptive Increase in Seismic Velocity Below Great Sitkin Volcano Due To Magma Extrusion by Kupres, Cody A., Yang, Xiaotao, Haney, Matthew, Roman, Diana C.

“…Volcanic eruptions carry essential information on the dynamics of volcanic systems. Studies have documented variable eruption styles and eruptive surface…”
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Deep Long‐Period Earthquakes at Akutan Volcano From 2005 to 2017 Better Track Magma Influxes Compared to Volcano‐Tectonic Earthquakes by Song, Zilin, Tan, Yen Joe, Roman, Diana C.

“…Both volcano‐tectonic (VTs) and deep long‐period earthquakes (DLPs) have been documented at Akutan Volcano, Alaska and may reflect different active processes…”
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SARS-CoV-2 infection and sleep disturbances: nitric oxide involvement and therapeutic opportunity by Cespuglio, Raymond, Strekalova, Tatyana, Spencer, Peter S, Román, Gustavo C, Reis, Jacques, Bouteille, Bernard, Buguet, Alain

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Epidermal growth factor receptor expression is associated with poor outcome in cutaneous squamous cell carcinoma by Canueto, J, Cardenoso, E, Garcia, JL, Santos-Briz, Á, Castellanos-Martin, A, Fernandez-Lopez, E, Blanco Gomez, A, Perez-Losada, J, Roman-Curto, C

“…Summary Background Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans after basal cell carcinoma, and its incidence is…”
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Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo by Pusch, Stefan, Krausert, Sonja, Fischer, Viktoria, Balss, Jörg, Ott, Martina, Schrimpf, Daniel, Capper, David, Sahm, Felix, Eisel, Jessica, Beck, Ann-Christin, Jugold, Manfred, Eichwald, Viktoria, Kaulfuss, Stefan, Panknin, Olaf, Rehwinkel, Hartmut, Zimmermann, Katja, Hillig, Roman C., Guenther, Judith, Toschi, Luisella, Neuhaus, Roland, Haegebart, Andrea, Hess-Stumpp, Holger, Bauser, Markus, Wick, Wolfgang, Unterberg, Andreas, Herold-Mende, Christel, Platten, Michael, von Deimling, Andreas

“…Mutations in codon 132 of isocitrate dehydrogenase ( IDH ) 1 are frequent in diffuse glioma, acute myeloid leukemia, chondrosarcoma and intrahepatic…”
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Double Reservoirs Imaged Below Great Sitkin Volcano, Alaska, Explain the Migration of Volcanic Seismicity by Yang, Xiaotao, Roman, Diana C., Haney, Matthew, Kupres, Cody A.

“…Volcanic seismicity provides essential insights into the behavior of an active volcano across multiple time scales. However, to understand how magma moves as…”
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Forecasting radiation fog at climatologically contrasting sites: evaluation of statistical methods and WRF by Román‐Cascón, C., Steeneveld, G. J., Yagüe, C., Sastre, M., Arrillaga, J. A., Maqueda, G.

“…A six‐year climatology of radiation fog has been compiled at two sites: the Research Centre for the Lower Atmosphere (CIBA, Spain) and the Cabauw Experimental…”
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Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N‑[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile by Werner, Stefan, Mesch, Stefanie, Hillig, Roman C, ter Laak, Antonius, Klint, Julie, Neagoe, Ioana, Laux-Biehlmann, Alexis, Dahllöf, Henrik, Bräuer, Nico, Puetter, Vera, Nubbemeyer, Reinhard, Schulz, Simone, Bairlein, Michaela, Zollner, Thomas M, Steinmeyer, Andreas

“…The P2X4 receptor is a ligand-gated ion channel that is expressed on a variety of cell types, especially those involved in inflammatory and immune processes…”
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Sources of Inaccuracy in Photoplethysmography for Continuous Cardiovascular Monitoring by Fine, Jesse, Branan, Kimberly L, Rodriguez, Andres J, Boonya-Ananta, Tananant, Ajmal, Ramella-Roman, Jessica C, McShane, Michael J, Coté, Gerard L

“…Photoplethysmography (PPG) is a low-cost, noninvasive optical technique that uses change in light transmission with changes in blood volume within tissue to…”
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Environmental neurology: Concepts and short history of an interdisciplinary approach to etiology, treatment and prevention by Reis, Jacques, Buguet, Alain, Román, Gustavo C, Spencer, Peter S

“…Environmental Neurology (EN), a sub-discipline of Neurology and Neurological Sciences, favors an interdisciplinary collaboration allowing a holistic approach…”
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Targeting fibroblast activation protein in newly diagnosed squamous cell carcinoma of the oral cavity – initial experience and comparison to [18F]FDG PET/CT and MRI by Linz, Christian, Brands, Roman C., Kertels, Olivia, Dierks, Alexander, Brumberg, Joachim, Gerhard-Hartmann, Elena, Hartmann, Stefan, Schirbel, Andreas, Serfling, Sebastian, Zhi, Yingjun, Buck, Andreas K., Kübler, Alexander, Hohm, Julian, Lapa, Constantin, Kircher, Malte

“…Purpose While [ 18 F]-fluorodeoxyglucose ([ 18 F]FDG) is the standard for positron emission tomography/computed tomography (PET/CT) imaging of oral squamous…”
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The Quest for the Missing Dust. II. Two Orders of Magnitude of Evolution in the Dust-to-gas Ratio Resolved within Local Group Galaxies by Clark, Christopher J. R., Roman-Duval, Julia C., Gordon, Karl D., Bot, Caroline, Smith, Matthew W. L., Hagen, Lea M. Z.

“…Abstract We explore evolution in the dust-to-gas ratio with density within four well-resolved Local Group galaxies—the LMC, SMC, M31, and M33. We do this using…”
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