Search Results - "Roman, Brian B"

In vivo biodistribution and clearance of peptide amphiphile micelles by Chung, Eun Ji, PhD, Mlinar, Laurie B., BS, Sugimoto, Matthew J., BS, Nord, Kathryn, BS, Roman, Brian B., PhD, Tirrell, Matthew, PhD

“…Abstract Peptide amphiphiles (PAs) are promising biomaterials for medical applications. To translate the use of PAs successfully from laboratories to clinics,…”
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Biocompatibility of nanoporous alumina membranes for immunoisolation by La Flamme, Kristen E, Popat, Ketul C, Leoni, Lara, Markiewicz, Erica, La Tempa, Thomas J, Roman, Brian B, Grimes, Craig A, Desai, Tejal A

“…Abstract Cellular immunoisolation using semi-permeable barriers has been investigated over the past several decades as a promising treatment approach for…”
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Genetic background influences adaptation to cardiac hypertrophy and Ca2+ handling gene expression by Waters, Steve B., Diak, Douglass M., Zuckermann, Matthew, Goldspink, Paul H., Leoni, Lara, Roman, Brian B.

“…Genetic variability has a profound effect on the development of cardiac hypertrophy in response to stress. Consequently, using a variety of inbred mouse…”
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Functional MR microimaging of pancreatic beta-cell activation by Gimi, Barjor, Leoni, Lara, Oberholzer, Jose, Braun, Mark, Avila, Jose, Wang, Yong, Desai, Tejal, Philipson, Louis H, Magin, Richard L, Roman, Brian B

“…The increasing incidence of diabetes and the need to further understand its cellular basis has resulted in the development of new diagnostic and therapeutic…”
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Phosphocreatine kinetics at the onset of contractions in skeletal muscle of MM creatine kinase knockout mice by Roman, Brian B, Meyer, Ronald A, Wiseman, Robert W

“…Phosphocreatine (PCr) depletion during isometric twitch stimulation at 5 Hz was measured by (31)P-NMR spectroscopy in gastrocnemius muscles of…”
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The optimal 18F-fluoromisonidazole PET threshold to define tumor hypoxia in preclinical squamous cell carcinomas using pO2 electron paramagnetic resonance imaging as reference truth by Gertsenshteyn, Inna, Epel, Boris, Ahluwalia, Amandeep, Kim, Heejong, Fan, Xiaobing, Barth, Eugene, Zamora, Marta, Markiewicz, Erica, Tsai, Hsiu-Ming, Sundramoorthy, Subramanian, Leoni, Lara, Lukens, John, Bhuiyan, Mohammed, Freifelder, Richard, Kucharski, Anna, Giurcanu, Mihai, Roman, Brian B., Karczmar, Gregory, Kao, Chien-Min, Halpern, Howard, Chen, Chin-Tu

“…Purpose To identify the optimal threshold in 18 F-fluoromisonidazole (FMISO) PET images to accurately locate tumor hypoxia by using electron paramagnetic…”
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Manganese-enhanced MRI detection of impaired calcium regulation in a mouse model of cardiac hypertrophy by Andrews, Martin, Giger, Maryellen L., Roman, Brian B.

“…The aim of this study was to use manganese (Mn)‐enhanced MRI (MEMRI) to detect changes in calcium handling associated with cardiac hypertrophy in a mouse…”
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Magnetic Resonance Imaging and Molecular Characterization of a Hormone-Mediated Murine Model of Prostate Enlargement and Bladder Outlet Obstruction by McAuley, Erin M., Mustafi, Devkumar, Simons, Brian W., Valek, Rebecca, Zamora, Marta, Markiewicz, Erica, Lamperis, Sophia, Williams, Anthony, Roman, Brian B., Vezina, Chad, Karczmar, Greg, Oto, Aytekin, Vander Griend, Donald J.

“…Urinary complications resulting from benign prostatic hyperplasia and bladder outlet obstruction continue to be a serious health problem. Novel animal model…”
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Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity by Sundaram, Karthik M, Zhang, Yilin, Mitra, Anirban K, Kouadio, Jean-Louis K, Gwin, Katja, Kossiakoff, Anthony A, Roman, Brian B, Lengyel, Ernst, Piccirilli, Joseph A

“…Poor prognosis of ovarian cancer, the deadliest of the gynecologic malignancies, reflects major limitations associated with detection and diagnosis. Current…”
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Empirical mathematical model for dynamic manganese-enhanced MRI of the murine pancreas for assessment of β-cell function by Dhyani, Anita H, Fan, Xiaobing, Leoni, Lara, Haque, Muhammad, Roman, Brian B

“…Abstract Autoimmune ablation of pancreatic β-cells and alteration of its microvasculature may be a predictor of Type I diabetes development. A dynamic…”
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High resolution 3D MRI of mouse mammary glands with intra-ductal injection of contrast media by Markiewicz, Erica, Fan, Xiaobing, Mustafi, Devkumar, Zamora, Marta, Roman, Brian B, Jansen, Sanaz A, Macleod, Kay, Conzen, Suzanne D, Karczmar, Gregory S

“…Abstract The purpose of this study was to use high resolution three-dimensional (3D) magnetic resonance imaging (MRI) to study mouse mammary gland ductal…”
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Functional MRI characterization of isolated human islet activation by Leoni, Lara, Serai, Suraj D., Magin, Richard L., Roman, Brian B.

“…The noninvasive assessment of pancreatic islets would be an invaluable tool in advancing the treatment of type I diabetes and in understanding its…”
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If the skull fits: magnetic resonance imaging and microcomputed tomography for combined analysis of brain and skull phenotypes in the mouse by Nieman, Brian J, Blank, Marissa C, Roman, Brian B, Henkelman, R Mark, Millen, Kathleen J

“…The mammalian brain and skull develop concurrently in a coordinated manner, consistently producing a brain and skull that fit tightly together. It is common…”
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Genetic background influences adaptation to cardiac hypertrophy and Ca(2+) handling gene expression by Waters, Steve B, Diak, Douglass M, Zuckermann, Matthew, Goldspink, Paul H, Leoni, Lara, Roman, Brian B

“…Genetic variability has a profound effect on the development of cardiac hypertrophy in response to stress. Consequently, using a variety of inbred mouse…”
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Comparison and evaluation of mouse cardiac MRI acquired with open birdcage, single loop surface and volume birdcage coils by Fan, Xiaobing, Markiewicz, Erica J, Zamora, Marta, Karczmar, Gregory S, Roman, Brian B

“…Although the quality and speed of MR images have vastly improved with the development of novel RF coil technologies, the engineering expertise required to…”
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Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo by Roman, Brian B, Goldspink, Paul H, Spaite, Elyse, Urboniene, Dalia, McKinney, Ron, Geenen, David L, Solaro, R John, Buttrick, Peter M

“…Protein kinase C (PKC) modulates cardiomyocyte function by phosphorylation of intracellular targets including myofilament proteins. Data generated from studies…”
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alpha-Adrenergic response and myofilament activity in mouse hearts lacking PKC phosphorylation sites on cardiac TnI by Montgomery, David E, Wolska, Beata M, Pyle, W Glen, Roman, Brian B, Dowell, Jasmine C, Buttrick, Peter M, Koretsky, Alan P, Del Nido, Pedro, Solaro, R John

“…Protein kinase C (PKC)-mediated phosphorylation of cardiac myofilament (MF) proteins has been shown to depress the actomyosin interaction and may be important…”
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Cardiac MRI of the normal and hypertrophied mouse heart by Slawson, S E, Roman, B B, Williams, D S, Koretsky, A P

“…With the development of recent transgenic techniques, studies involving mice offer opportunities to increase understanding of cardiac disease. This provides…”
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Functional Equivalence of Creatine Kinase Isoforms in Mouse Skeletal Muscle by Roman, Brian B., Wieringa, Bé, Koretsky, Alan P.

“…Creatine kinase (CK) is a highly conserved enzyme abundant in skeletal muscle that has a key role in high energy phosphate metabolism. The localization of the…”
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Mn-Enhanced MRI Detection of Impaired Calcium Regulation in a Mouse Model of Cardiac Hypertrophy by Andrews, Martin, Giger, Maryellen L., Roman, Brian B.

“…In this study we investigated use of manganese-enhanced MRI (MEMRI) for the detection of alterations in calcium dynamics in normal (C57BL/6) and creatine…”
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