Efficacy of Commercially Available Nutritional Supplements: Analysis of Serum Uptake, Macular Pigment Optical Density and Visual Functional Response

To compare the change in serum carotenoids, macular pigment optical density (MPOD) and visual function with the intake of two commercially available nutritional supplements. Participants were given a 24-week supply of a lipid-based micronized liquid medical food, Lumega-Z™ (LM), containing 28 mg of...

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Bibliographic Details
Published in:	Nutrients Vol. 12; no. 5; p. 1321
Main Authors:	Bone, Richard A, Davey, Pinakin Gunvant, Roman, Betzabe O, Evans, David W
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI 06-05-2020 MDPI AG
Subjects:	Adult Age Factors Carotenoids - administration & dosage Carotenoids - analysis Carotenoids - pharmacology Dietary Supplements Female Humans Lumega-Z lutein Lutein - administration & dosage Lutein - blood Lutein - pharmacology Macular Pigment - metabolism macular pigment optical density Male meso-zeaxanthin Middle Aged PreserVision Recommended Dietary Allowances Time Factors Vision, Ocular - drug effects Vision, Ocular - physiology Visual Acuity - drug effects Visual Acuity - physiology Young Adult zeaxanthin Zeaxanthins - administration & dosage Zeaxanthins - blood Zeaxanthins - pharmacology macular pigment optical density Lumega-Z PreserVision meso-zeaxanthin lutein contrast sensitivity zeaxanthin
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Summary:	To compare the change in serum carotenoids, macular pigment optical density (MPOD) and visual function with the intake of two commercially available nutritional supplements. Participants were given a 24-week supply of a lipid-based micronized liquid medical food, Lumega-Z™ (LM), containing 28 mg of the macular carotenoids lutein (L), zeaxanthin (Z) and -zeaxanthin (MZ), or given PreserVision™ AREDS 2 Formula (gel-caps; PV) containing 12 mg of the macular carotenoids L and Z, but no reported MZ. Serum levels of L, Z and MZ were obtained at baseline and after 12 weeks. Macular pigment optical densities (MPOD) and visual function were assessed at baseline and after 24 weeks. Average blood serum concentrations of L, Z and MZ in the two groups at baseline were similar. The increases in L, Z and MZ were 0.434, 0.063 and 0.086 mol/L vs. 0.100, 0.043 and 0.001 mol/L, respectively, in the LM vs. PV group. From baseline to week 24, average MPOD in the LM-group increased by 0.064 from 0.418 to 0.482, whereas in the PV-group, it was essentially unchanged (0.461 to 0.459;). Although log-contrast sensitivity was improved in all groups under three conditions (photopic, mesopic and mesopic with glare), the change in log-contrast sensitivity was not statistically significant Despite only a 2.3-fold higher carotenoid concentration than PV, LM supplementation provides approximately 3-4-fold higher absorption, which leads to a significant elevation of MPOD levels.
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu12051321