Search Results - "Roman, Bart I"

Glioblastoma-Associated Mesenchymal Stem/Stromal Cells and Cancer-Associated Fibroblasts: Partners in Crime? by Lootens, Thibault, Roman, Bart I, Stevens, Christian V, De Wever, Olivier, Raedt, Robrecht

“…Tumor-associated mesenchymal stem/stromal cells (TA-MSCs) have been recognized as attractive therapeutic targets in several cancer types, due to their ability…”
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Vehicle development, pharmacokinetics and toxicity of the anti-invasive agent 4-fluoro-3',4',5'-trimethoxychalcone in rodents by Mus, Liselot M, Denecker, Geertrui, Speleman, Frank, Roman, Bart I

“…Effective inhibitors of invasion and metastasis represent a serious unmet clinical need. We have recently identified 4-fluoro-3',4',5'-trimethoxychalcone or…”
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Transglucosylation potential of six sucrose phosphorylases toward different classes of acceptors by Aerts, Dirk, Verhaeghe, Tom F., Roman, Bart I., Stevens, Christian V., Desmet, Tom, Soetaert, Wim

“…In this study, the transglucosylation potential of six sucrose phosphorylase (SP) enzymes has been compared using eighty putative acceptors from different…”
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The Expanding Role of Chemistry in Optimizing Proteins for Human Health Applications: Miniperspective by Roman, Bart I

“…Over the past decades, therapeutics based on biological macromolecules and cells have successfully entered the clinical arena and progressively occupied an…”
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The Expanding Role of Chemistry in Optimizing Proteins for Human Health Applications by Roman, Bart I

“…Over the past decades, therapeutics based on biological macromolecules and cells have successfully entered the clinical arena and progressively occupied an…”
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Design, synthesis and structure–activity relationships of some novel, highly potent anti-invasive (E)- and (Z)-stilbenes by Roman, Bart I., De Coen, Laurens M., Thérèse F.C. Mortier, Séverine, De Ryck, Tine, Vanhoecke, Barbara W.A., Katritzky, Alan R., Bracke, Marc E., Stevens, Christian V.

“…In our ongoing exploration of the structure–activity landscape of anti-invasive chalcones, we have prepared and evaluated a number of structurally related (E)-…”
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Medicinal Chemistry and Use of Myosin II Inhibitor (S)‑Blebbistatin and Its Derivatives by Roman, Bart I, Verhasselt, Sigrid, Stevens, Christian V

“…(S)-Blebbistatin, a chiral tetrahydropyrroloquinolinone, is a widely used and well-characterized ATPase inhibitor selective for myosin II. The central role of…”
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Recovering Actives in Multi-Antitarget and Target Design of Analogs of the Myosin II Inhibitor Blebbistatin by Roman, Bart I, Guedes, Rita C, Stevens, Christian V, García-Sosa, Alfonso T

“…In multitarget drug design, it is critical to identify active and inactive compounds against a variety of targets and antitargets. Multitarget strategies thus…”
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Microbial inhibition of oral epithelial wound recovery: potential role for quorum sensing molecules? by De Ryck, Tine, Vanlancker, Eline, Grootaert, Charlotte, Roman, Bart I., De Coen, Laurens M, Vandenberghe, Isabel, Stevens, Christian V, Bracke, Marc, Van de Wiele, Tom, Vanhoecke, Barbara

“…Awareness of the impact of microbiota in both health and disease is growing. Using a new in vitro oral mucosa co-culture model, we recently showed a clear…”
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Synthesis of isoindoles and related iso-condensed heteroaromatic pyrroles by Heugebaert, Thomas S A, Roman, Bart I, Stevens, Christian V

“…Over the past few years, isoindoles have found wide application in materials science. Isoindole containing BODIPY dyes are highly fluorescent materials and…”
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Homogeneous Gold-Catalyzed Cyclization Reactions of Alkynes with N- and S-Nucleophiles by Debrouwer, Wouter, Heugebaert, Thomas S. A., Roman, Bart I., Stevens, Christian V.

“…This review covers the formation of N‐ and S‐containing heterocycles, initiated by gold‐catalyzed nucleophilic attack of N‐ or S‐nucleophiles onto alkynes…”
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Essay: Avoiding unfounded health claims on small molecules in scientific literature by Roman, Bart I.

“…[Display omitted] •Unfounded health claims pollute scientific literature.•Discussion of human and scientific causes.•Suggestion of corrective actions to be…”
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Improved synthesis and comparative analysis of the tool properties of new and existing D-ring modified (S)-blebbistatin analogs by Verhasselt, Sigrid, Roman, Bart I., Bracke, Marc E., Stevens, Christian V.

“…(S)-Blebbistatin is a widely used research tool to study myosin II, an important regulator of many motility based diseases. Its potency is too low to be of…”
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Insights into the myosin II inhibitory potency of A-ring-modified (S)-blebbistatin analogs by Verhasselt, Sigrid, Stevens, Christian V., Van den broecke, Tom, Bracke, Marc E., Roman, Bart I.

“…[Display omitted] Myosin II is an interesting target for therapeutic intervention, as it is involved in a large number of motility-based diseases…”
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Synthesis and Biological Activity of Oxazolopyrimidines by De Coen, Laurens M., Roman, Bart I., Movsisyan, Marine, Heugebaert, Thomas S. A., Stevens, Christian V.

“…In this work, the synthesis of oxazolo[4,5‐d]pyrimidines and oxazolo[5,4‐d]pyrimidines is reviewed. The review is focused on the construction of the scaffold…”
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Synthesis of C-ring-modified blebbistatin derivatives and evaluation of their myosin II ATPase inhibitory potency by Roman, Bart I., Verhasselt, Sigrid, Mangodt, Christophe W., De Wever, Olivier, Stevens, Christian V.

“…[Display omitted] •First report on C-ring-modified blebbistatin analogs.•Incorporation of hydroxymethyl or allyloxymethyl functionalities.•Additional favorable…”
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Discovery of (S)-3'-hydroxyblebbistatin and (S)-3'-aminoblebbistatin: polar myosin II inhibitors with superior research tool properties by Verhasselt, Sigrid, Roman, Bart I, De Wever, Olivier, Van Hecke, Kristof, Van Deun, Rik, Bracke, Marc E, Stevens, Christian V

“…In search of myosin II inhibitors with superior research tool properties, a chemical optimization campaign of the blebbistatin scaffold was conducted in this…”
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Continuous‐Flow Synthesis of Phenothiazine Antipsychotics: A Feasibility Study by Movsisyan, Marine, De Coen, Laurens M., Heugebaert, Thomas S. A., Verlee, Arno, Roman, Bart I., Stevens, Christian V.

“…The continuous flow synthesis of a model phenothiazine antipsychotic is presented herein, using 3‐chloropropionyl chloride as a central building block. The…”
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Atom‐ and Mass‐economical Continuous Flow Production of 3‐Chloropropionyl Chloride and its Subsequent Amidation by Movsisyan, Marine, Heugebaert, Thomas S. A., Roman, Bart I., Dams, Rudolf, Van Campenhout, Rudy, Conradi, Matthias, Stevens, Christian V.

“…3‐Chloropropionyl chloride is a chemically versatile building block with applications in the field of adhesives, pharmaceuticals, herbicides and fungicides…”
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Synthesis of β-, γ-, δ-, ..., ω-Halogenated Ketones and Aldehydes by Roman, Bart I, Kimpe, Norbert De, Stevens, Christian V

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