Search Results - "Romain, R."

Heparan Sulfate Proteoglycans Biosynthesis and Post Synthesis Mechanisms Combine Few Enzymes and Few Core Proteins to Generate Extensive Structural and Functional Diversity by Annaval, Thibault, Wild, Rebekka, Crétinon, Yoann, Sadir, Rabia, Vivès, Romain R, Lortat-Jacob, Hugues

“…Glycosylation is a common and widespread post-translational modification that affects a large majority of proteins. Of these, a small minority, about 20, are…”
Get full text

The “in and out” of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate by El Masri, Rana, Seffouh, Amal, Lortat-Jacob, Hugues, Vivès, Romain R.

“…The biological properties of Heparan sulfate (HS) polysaccharides essentially rely on their ability to bind and modulate a multitude of protein ligands. These…”
Get full text

Heparan Sulfate Biosynthesis and Sulfation Profiles as Modulators of Cancer Signalling and Progression by Marques, Catarina, Reis, Celso A., Vivès, Romain R., Magalhães, Ana

“…Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix (ECM) maestros involved in the orchestration of multiple cellular…”
Get full text

Sweet but Challenging: Tackling the Complexity of GAGs with Engineered Tailor‐Made Biomaterials by Le Pennec, Jean, Picart, Catherine, Vivès, Romain R., Migliorini, Elisa

“…Glycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the activity and diffusion of bioactive molecules. Incorporating GAGs into…”
Get full text

HS and Inflammation: A Potential Playground for the Sulfs? by El Masri, Rana, Crétinon, Yoann, Gout, Evelyne, Vivès, Romain R

“…Heparan sulfate (HS) is a complex polysaccharide abundantly found in extracellular matrices and cell surfaces. HS participates in major cellular processes,…”
Get full text

Role of the interactions of soft hyaluronan nanomaterials with CD44 and supported bilayer membranes in the cellular uptake by Diaz-Salmeron, Raul, Michel, Jean-Philippe, Hadji, Hicheme, Gout, Evelyne, Vivès, Romain. R., Ponchel, Gilles, Bouchemal, Kawthar

“…[Display omitted] •Soft hyaluronic acid nanoplatelets had flat surfaces and high aspect ratio.•Cell internalization of nanoplatelets was higher than native…”
Get full text

Langerin–Heparin Interaction: Two Binding Sites for Small and Large Ligands As Revealed by a Combination of NMR Spectroscopy and Cross-Linking Mapping Experiments by Muñoz-García, Juan C, Chabrol, Eric, Vivès, Romain R, Thomas, Aline, de Paz, José L, Rojo, Javier, Imberty, Anne, Fieschi, Franck, Nieto, Pedro M, Angulo, Jesús

“…Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent…”
Get full text

Glycosaminoglycans exhibit distinct interactions and signaling with BMP2 according to their nature and localization by Le Pennec, Jean, Makshakova, Olga, Nevola, Paola, Fouladkar, Farah, Gout, Evelyne, Machillot, Paul, Friedel-Arboleas, Mélanie, Picart, Catherine, Perez, Serge, Vortkamp, Andrea, Vivès, Romain R., Migliorini, Elisa

“…The role of glycosaminoglycans (GAGs) in modulating bone morphogenetic protein (BMP) signaling represents a recent and underexplored area. Conflicting reports…”
Get full text

A biological guide to glycosaminoglycans: current perspectives and pending questions by Ricard‐Blum, Sylvie, Vivès, Romain R., Schaefer, Liliana, Götte, Martin, Merline, Rosetta, Passi, Alberto, Heldin, Paraskevi, Magalhães, Ana, Reis, Celso A., Skandalis, Spyros S., Karamanos, Nikos K., Perez, Serge, Nikitovic, Dragana

“…Mammalian glycosaminoglycans (GAGs), except hyaluronan (HA), are sulfated polysaccharides that are covalently attached to core proteins to form proteoglycans…”
Get full text

Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2) by Kennett, Alice, Epple, Sven, van der Valk, Gabriella, Georgiou, Irene, Gout, Evelyne, Vivès, Romain R, Russell, Angela J

“…Sulf-2 has been identified as a putative target for anticancer therapies. Here we report the design and synthesis of sulfated disaccharide inhibitors based on…”
Get more information

Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates heparan sulfate biosynthesis and shapes gastric cancer cell motility and invasion by Marques, Catarina, Poças, Juliana, Gomes, Catarina, Faria-Ramos, Isabel, Reis, Celso A., Vivès, Romain R., Magalhães, Ana

“…Heparan sulfate (HS) proteoglycans (HSPGs) are abundant glycoconjugates in cells’ glycocalyx and extracellular matrix. By acting as scaffolds for…”
Get full text

Proteinuria converts hepatic heparan sulfate to an effective proprotein convertase subtilisin kexin type 9 enzyme binding partner by Shrestha, Pragyi, Yazdani, Saleh, Vivès, Romain R, El Masri, Rana, Dam, Wendy, van de Sluis, Bart, van den Born, Jacob

“…Hepatic uptake of triglyceride-rich remnant lipoproteins is mediated by the low-density lipoprotein receptor, a low-density lipoprotein receptor related…”
Get more information

Myeloid deficiency of heparan sulfate 6-O-endosulfatases impairs bone marrow hematopoiesis by Whitehead, Anna K., Wang, Zhangjie, Boustany, Rebecca-Joe, Vivès, Romain R., Lazartigues, Eric, Liu, Jian, Siggins, Robert W., Yue, Xinping

“…•Myeloid deficiency of heparan sulfate 6-O-endosulfatases (or the Sulfs) leads to multilineage abnormalities in bone marrow hematopoiesis in an age- and…”
Get full text

Post-Synthetic Regulation of HS Structure: The Yin and Yang of the Sulfs in Cancer by Vivès, Romain R, Seffouh, Amal, Lortat-Jacob, Hugues

“…Heparan sulfate (HS) is a complex polysaccharide that takes part in most major cellular processes, through its ability to bind and modulate a very large array…”
Get full text

Expression and purification of recombinant extracellular sulfatase HSulf-2 allows deciphering of enzyme sub-domain coordinated role for the binding and 6-O-desulfation of heparan sulfate by Seffouh, Amal, El Masri, Rana, Makshakova, Olga, Gout, Evelyne, Hassoun, Zahra el Oula, Andrieu, Jean-pierre, Lortat-Jacob, Hugues, Vivès, Romain R.

“…Through their ability to edit 6- O -sulfation pattern of Heparan sulfate (HS) polysaccharides, Sulf extracellular endosulfatases have emerged as critical…”
Get full text

Structure and functional impact of glycosaminoglycan modification of HSulf-2 endosulfatase revealed by atomic force microscopy and mass spectrometry by Seffouh, Ilham, Bilong, Mélanie, Przybylski, Cédric, El Omrani, Nesrine, Poyer, Salomé, Lamour, Guillaume, Clément, Marie-Jeanne, Boustany, Rebecca-Joe, Gout, Evelyne, Gonnet, Florence, Vivès, Romain R., Daniel, Régis

“…The human sulfatase HSulf-2 is one of only two known endosulfatases that play a decisive role in modulating the binding properties of heparan sulfate…”
Get full text

BMP2 Binds Non‐Specifically to PEG‐Passivated Biomaterials and Induces pSMAD 1/5/9 Signalling by Pennec, Jean Le, Guibert, Amaury, Gurram, Raviteja, Delon, Antoine, Vivès, Romain R., Migliorini, Elisa

“…Biomaterials are widely employed across diverse biomedical applications and represent an attractive strategy to explore how extracellular matrix components…”
Get full text

Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches by Kerever, Aurelien, Nagahara, Fumina, Keino-Masu, Kazuko, Masu, Masayuki, van Kuppevelt, Toin H, Vivès, Romain R, Arikawa-Hirasawa, Eri

“…Abstract Fractones, specialized extracellular matrix structures found in the subventricular zone (SVZ) neurogenic niche, can capture growth factors, such as…”
Get full text

A proliferation‐inducing ligand–mediated anti‐inflammatory response of astrocytes in multiple sclerosis by Baert, Laurie, Benkhoucha, Mahdia, Popa, Natalia, Ahmed, Mashal C., Manfroi, Benoit, Boutonnat, Jean, Sturm, Nathalie, Raguenez, Gilda, Tessier, Marine, Casez, Olivier, Marignier, Romain, Ahmadi, Mitra, Broisat, Alexis, Ghezzi, Catherine, Rivat, Cyril, Sonrier, Corinne, Hahne, Michael, Baeten, Dominique, Vives, Romain R., Lortat‐Jacob, Hugues, Marche, Patrice N., Schneider, Pascal, Lassmann, Hans P., Boucraut, Jose, Lalive, Patrice H., Huard, Bertrand

“…Objective The two related tumor necrosis factor members a proliferation‐inducing ligand (APRIL) and B‐cell activation factor (BAFF) are currently targeted in…”
Get full text

Endothelial glycocalyx degradation in multisystem inflammatory syndrome in children related to COVID-19 by Veraldi, Noemi, Vivès, Romain R., Blanchard-Rohner, Géraldine, L’Huillier, Arnaud G., Wagner, Noemie, Rohr, Marie, Beghetti, Maurice, De Agostini, Ariane, Grazioli, Serge

“…Multisystem inflammatory syndrome in children (MIS-C) represents a rare but severe complication of severe acute respiratory syndrome coronavirus 2 infection…”
Get full text