Search Results - "Romagnoli, Mathilde"

Alpha-6 integrin deletion delays the formation of Brca1/p53-deficient basal-like breast tumors by restricting luminal progenitor cell expansion by Faraldo, Marisa M, Romagnoli, Mathilde, Wallon, Loane, Dubus, Pierre, Deugnier, Marie-Ange, Fre, Silvia

“…The aberrant amplification of mammary luminal progenitors is at the origin of basal-like breast cancers associated with BRCA1 mutations. Integrins mediate…”
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Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation by Romagnoli, Mathilde, Bresson, Laura, Di-Cicco, Amandine, Pérez-Lanzón, María, Legoix, Patricia, Baulande, Sylvain, de la Grange, Pierre, De Arcangelis, Adèle, Georges-Labouesse, Elisabeth, Sonnenberg, Arnoud, Deugnier, Marie-Ange, Glukhova, Marina A, Faraldo, Marisa M

“…Integrin dimers α3/β1, α6/β1 and α6/β4 are the mammary epithelial cell receptors for laminins, which are major components of the mammary basement membrane. The…”
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Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1―Dependent Repression of BMP-5 by ROMAGNOLI, Mathilde, BELGUISE, Karine, SONENSHEIN, Gail E, ZIYANG YU, XIAOBO WANG, LANDESMAN-BOLLAG, Esther, SELDIN, David C, CHALBOS, Dany, BARILLE-NION, Sophie, JEZEQUEL, Pascal, SELDIN, Margaret L

“…Induction of epithelial-to-mesenchymal transition (EMT) by TGF-β1 requires Ras signaling. We recently identified the transcriptional repressor Blimp-1 (PRDM1)…”
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ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis by Romagnoli, Mathilde, Mineva, Nora D, Polmear, Michael, Conrad, Catharina, Srinivasan, Srimathi, Loussouarn, Delphine, Barillé‐Nion, Sophie, Georgakoudi, Irene, Dagg, Áine, McDermott, Enda W, Duffy, Michael J, McGowan, Patricia M., Schlomann, Uwe, Parsons, Maddy, Bartsch, Jörg W, Sonenshein, Gail E

“…The transmembrane metalloprotease‐disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors and extracellular matrix components. Here, we…”
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Paracrine Met signaling triggers epithelial-mesenchymal transition in mammary luminal progenitors, affecting their fate by Di-Cicco, Amandine, Petit, Valérie, Chiche, Aurélie, Bresson, Laura, Romagnoli, Mathilde, Orian-Rousseau, Véronique, Vivanco, Maria dM, Medina, Daniel, Faraldo, Marisa M, Glukhova, Marina A, Deugnier, Marie-Ange

“…HGF/Met signaling has recently been associated with basal-type breast cancers, which are thought to originate from progenitor cells residing in the luminal…”
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RelB NF-κB Represses Estrogen Receptor α Expression via Induction of the Zinc Finger Protein Blimp1 by Wang, Xiaobo, Belguise, Karine, O'Neill, Christine F., Sánchez-Morgan, Nuria, Romagnoli, Mathilde, Eddy, Sean F., Mineva, Nora D., Yu, Ziyang, Min, Chengyin, Trinkaus-Randall, Vickery, Chalbos, Dany, Sonenshein, Gail E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins by Romagnoli, Mathilde, Cagnet, Stéphanie, Chiche, Aurélie, Bresson, Laura, Baulande, Sylvain, de la Grange, Pierre, De Arcangelis, Adèle, Kreft, Maaike, Georges-Labouesse, Elisabeth, Sonnenberg, Arnoud, Deugnier, Marie-Ange, Raymond, Karine, Glukhova, Marina A., Faraldo, Marisa M.

“…Integrins, which bind laminin, a major component of the mammary basement membrane, are strongly expressed in basal stem cell-enriched populations, but their…”
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Notch2 signaling sensitizes endothelial cells to apoptosis by negatively regulating the key protective molecule survivin by Quillard, Thibaut, Devalliere, Julie, Chatelais, Mathias, Coulon, Flora, Séveno, Céline, Romagnoli, Mathilde, Barillé Nion, Sophie, Charreau, Béatrice

“…Notch signaling pathway controls key functions in vascular and endothelial cells (ECs) where Notch4 plays a major role. However, little is known about the…”
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Canonical Nuclear Factor κB Pathway Inhibition Blocks Myeloma Cell Growth and Induces Apoptosis in Strong Synergy with TRAIL by ROMAGNOLI, Mathilde, DESPLANQUES, Gregoire, MAÏGA, Sophie, LEGOUILL, Steven, DREANO, Michel, BATAILLE, Régis, BARILLA-NION, Sophie

“…Purpose: Intrinsic activation of nuclear factor κB (NF-κB) characterizes various hematologic malignancies. In this study, we specifically address the role of…”
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Trial in Progress: An Open Label Phase I/II, Multicenter Study Evaluating Safety, Pharmacokinetics and Efficacy of S65487, a BCL-2 Inhibitor Combined with Azacitidine in Adults with Previously Untreated Acute Myeloid Leukemia Ineligible for Intensive Treatment by Pierola, Ana Alfonso, De Botton, Stephane, Jang, Jun Ho, Campbell, Victoria, O'Nions, Jenny, Calbacho, Maria, Ervin-Haynes, Annette L., Keagle, Kristen, Maillard, Aline, Beneton, Maud, Romagnoli, Mathilde, Broniscer, Alberto

“…Preclinical and clinical data support combining Bcl-2 inhibitors (Bcl-2i) with hypomethylating agents (HMAs) in the treatment of acute myeloid leukemia (AML)…”
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N-Glycosylation Regulates ADAM8 Processing and Activation by Srinivasan, Srimathi, Romagnoli, Mathilde, Bohm, Andrew, Sonenshein, Gail E.

“…The transmembrane ADAM8 (ADisintegrin And Metalloproteinase 8) protein is abundantly expressed in human breast tumors and derived metastases compared with…”
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miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells by Das, Sonia G, Romagnoli, Mathilde, Mineva, Nora D, Barillé-Nion, Sophie, Jézéquel, Pascal, Campone, Mario, Sonenshein, Gail E

“…ADAM8 (a disintegrin and metalloproteinase 8) protein promotes the invasive and metastatic phenotype of triple-negative breast cancer (TNBC) cells. High ADAM8…”
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Abstract 1137: ADAM8 drives aggressive phenotype of triple-negative inflammatory breast cancer & constitutes a novel therapeutic target by Romagnoli, Mathilde, Pianetti, Stefania, Das, Sonia G., Loussouarn, Delphine, Gourmelon, Carole, Campone, Mario, Barillé-Nion, Sophie, Nguyen, Giang T., Srinivasan, Srimathi, Sonenshein, Gail E., Mineva, Nora D.

“…Abstract Inflammatory Breast Cancer (IBC) is a rare, highly aggressive form of cancer that is frequently locally advanced or metastasized at the time of…”
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Endogenous light scattering as an optical signature of circulating tumor cell clusters by Lyons, Joe, Polmear, Michael, Mineva, Nora D, Romagnoli, Mathilde, Sonenshein, Gail E, Georgakoudi, Irene

“…Circulating tumor cell clusters (CTCCs) are significantly more likely to form metastases than single tumor cells. We demonstrate the potential of…”
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Abstract B166: MicroRNAs downstream of ADAM8 as therapeutic targets and non-invasive biomarkers for triple-negative breast cancer by Das, Sonia G., Romagnoli, Mathilde, Mineva, Nora D., Sonenshein, Gail E.

“…Abstract Triple-negative breast cancer (TNBC) represents ∼20% of breast cancers, is highly aggressive and lacks targeted therapies due to the absence of…”
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Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis by Min, Chengyin, Zhao, Yingshe, Romagnoli, Mathilde, Trackman, Philip C., Sonenshein, Gail E., Kirsch, Kathrin H.

“…RAS mutations or its activation by upstream receptor tyrosine kinases are frequently associated with poor response of carcinomas to chemotherapy. The 18 kDa…”
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Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins by Romagnoli, Mathilde, Cagnet, Stéphanie, Chiche, Aurélie, Bresson, Laura, Baulande, Sylvain, de la Grange, Pierre, De Arcangelis, Adèle, Kreft, Maaike, Georges-Labouesse, Elisabeth, Sonnenberg, Arnoud, Deugnier, Marie-Ange, Raymond, Karine, Glukhova, Marina A., Faraldo, Marisa M.

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Abstract B62: ADAM8 promotes tumorigenesis, angiogenesis, and spreading of circulating tumor cells in breast cancer by Romagnoli, Mathilde, Mineva, Nora D., Loussouarn, Delphine, Barillé-Nion, Sophie, Polmear, Mike, Georgakoudi, Irene, Conrad, Catharina, Schlomann, Uwe, Bartsch, Joerg W., Parsons, Maddy, Sonenshein, Gail E.

“…Abstract ADAM (a disintegrin and metalloprotease) proteins mediate cell adhesion and shedding of receptors and proteins of the extracellular matrix via their…”
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Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation by Romagnoli, Mathilde, Bresson, Laura, Di-Cicco, Amandine, Pérez-Lanzón, María, Legoix, Patricia, Baulande, Sylvain, de la Grange, Pierre, De Arcangelis, Adèle, Georges-Labouesse, Elisabeth, Sonnenberg, Arnoud, Deugnier, Marie-Ange, Glukhova, Marina A, Faraldo, Marisa M

“…Integrin dimers α3/β1, α6/β1 and α6/β4 are the mammary epithelial cell receptors for laminins, which are major components of the mammary basement membrane. The…”
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The imbalance between Survivin and Bim mediates tumour growth and correlates with poor survival in patients with multiple myeloma by Romagnoli, Mathilde, Séveno, Céline, Wuillème‐Toumi, Soraya, Amiot, Martine, Bataille, Régis, Minvielle, Stéphane, Barillé‐Nion, Sophie

“…Summary Survivin is selectively expressed in most of common human cancers and is now viewed as a potent modulator of the cell death/proliferation balance in…”
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