Search Results - "Roma, Pahwa"

Toll-like receptors 2 and 4 mediate hyperglycemia induced macrovascular aortic endothelial cell inflammation and perturbation of the endothelial glycocalyx by Pahwa, Roma, Nallasamy, Palanisamy, Jialal, Ishwarlal

“…Abstract Objectives Hyperglycemia-induced inflammation is central to the vascular complications in diabetes. Toll-like receptors (TLRs) are key players in…”
Get full text

Fetuin-A is also an adipokine by Jialal, Ishwarlal, Pahwa, Roma

“…Fetuin-A (FetA), which impairs insulin action is considered classically as a hepatokine. In patients with Metabolic Syndrome without the confounding of…”
Get full text

Surface-fill hydrogel attenuates the oncogenic signature of complex anatomical surface cancer in a single application by Majumder, Poulami, Singh, Anand, Wang, Ziqiu, Dutta, Kingshuk, Pahwa, Roma, Liang, Chen, Andrews, Caroline, Patel, Nimit L., Shi, Junfeng, de Val, Natalia, Walsh, Scott T. R., Jeon, Albert Byungyun, Karim, Baktiar, Hoang, Chuong D., Schneider, Joel P.

“…Tumours growing in a sheet-like manner on the surface of organs and tissues with complex topologies represent a difficult-to-treat clinical scenario. Their…”
Get full text

The Role of the High-Mobility Group Box1 protein-Toll like receptor Pathway in Diabetic Vascular Disease by Pahwa, Roma, Jialal, Ishwarlal

“…Abstract Increased Toll like receptors (TLRs) especially 2 and 4 have been demonstrated in obesity, metabolic syndrome (MetS) and diabetes resulting in…”
Get full text

MicroRNA-206 suppresses mesothelioma progression via the Ras signaling axis by Singh, Anand, Pruett, Nathanael, Pahwa, Roma, Mahajan, Arushi P., Schrump, David S., Hoang, Chuong D.

“…Malignant pleural mesothelioma (MPM) is an incurable surface neoplasm with peculiar pathobiology. MPM proliferates by using the tyrosine-kinase-Ras pathway…”
Get full text

Targeting FAcilitates Chromatin Transcription complex inhibits pleural mesothelioma and enhances immunotherapy by Singh, Anand, Pruett, Nathanael, Dixit, Shivani, Gara, Sudheer K, Wang, Haitao, Pahwa, Roma, Schrump, David S, Hoang, Chuong D

“…Diffuse pleural mesothelioma (DPM) is an aggressive therapy-resistant cancer with unique molecular features. Numerous agents have been tested, but clinically…”
Get full text

Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma by Pahwa, Roma, Dubhashi, Janhavi, Singh, Anand, Jailwala, Parthav, Lobanov, Alexei, Thomas, Craig J, Ceribelli, Michele, Wilson, Kelli, Ricketts, Christopher J, Vocke, Cathy D, Wells, Catherine, Bottaro, Donald P, Linehan, W. Marston, Neckers, Len, Srinivasan, Ramaprasad

“…Background There is no universally accepted treatment for patients with advanced papillary renal cell carcinoma (PRCC). The presence of activating mutations in…”
Get full text

Gut Microbiome and Inflammation: A Study of Diabetic Inflammasome-Knockout Mice by Luna, Ruth Ann, Chen, Xinpu, Jialal, Ishwarlal, Balderas, Miriam, Pahwa, Roma, Devaraj, Sridevi

“…Aims. Diabetes is a proinflammatory state, evidenced by increased pattern recognition receptors and the inflammasome (NOD-like receptor family pyrin domain…”
Get full text

Production, Purification, and Characterization of Polygalacturonase from Mucor circinelloides ITCC 6025 by Gupta, Reena, Singh, Smarika, Pahwa, Roma, Thakur, Akhilesh

“…Mucor circinelloides produced an extracellular polygalacturonase enzyme, the production of which was enhanced when various production parameters were…”
Get full text

Hyperglycemia Induces Toll-Like Receptor Activity Through Increased Oxidative Stress by Pahwa, Roma, Jialal, Ishwarlal

“…Hyperglycemia-induced oxidative stress and inflammation are central in the genesis of diabetic vascular complications. Toll-like receptors (TLRs) play a…”
Get more information

Quantification of daratumumab in the serum protein electrophoresis by Jialal, Ishwarlal, Pahwa, Roma

Get more information

The effect of increasing body mass index on cardio-metabolic risk and biomarkers of oxidative stress and inflammation in nascent metabolic syndrome by Pahwa, Roma, Adams-Huet, Beverley, Jialal, Ishwarlal

“…Abstract The effect of BMI defined obesity on cardio-metabolic features and biomarkers of oxidative stress and inflammation in patients with nascent metabolic…”
Get full text

The evolving role of toll-like receptors in diabetic vascular complications by Jialal, Ishwarlal, Pahwa, Roma

“…[...]there is an urgent need for studies using the TLR2 and TLR4 knockout mice crossed with the LDL receptor KO or ApoE KO mice to clearly establish a role for…”
Get full text

Investigation into the interference of the monoclonal antibody daratumumab on the free light chain assay by Rosenberg, Aaron Seth, Bainbridge, Scott, Pahwa, Roma, Jialal, Ishwarlal

“…Recently monoclonal antibody therapy has been introduced in the treatment of multiple Myeloma (MM). One such efficacious therapy is the anti-CD38 monoclonal…”
Get full text

Increased inflammasome activity in subcutaneous adipose tissue of patients with metabolic syndrome by Pahwa, Roma, Singh, Anand, Adams‐Huet, Beverley, Devaraj, Sridevi, Jialal, Ishwarlal

“…Aims The metabolic syndrome (MetS) is an inflammatory disorder associated with an increased risk for diabetes and atherosclerotic cardiovascular disease…”
Get full text

Modulation of PBMC-decay accelerating factor (PBMC-DAF) and cytokines in rheumatoid arthritis by Pahwa, Roma, Kumar, Uma, Das, Nibhriti

“…Studies have suggested that abnormal expression of complement regulatory proteins and cytokines contribute significantly to the path-physiology of rheumatoid…”
Get full text

Therapeutic Monoclonal Antibodies and the Value of the Free Light Chain Assay in Myeloma by Jialal, Ishwarlal, Pahwa, Roma, Beck, Rose C, Schmotzer, Christine L

Get full text

Cellular Signaling in Metabolic Syndrome by Pahwa, Roma, Jialal, Ishwarlal

Get more information

Selective increase in monocyte p38 mitogen-activated protein kinase activity in metabolic syndrome by Jialal, Ishwarlal, Adams-Huet, Beverley, Pahwa, Roma

“…Metabolic syndrome is a common disorder that predisposes to both cardiovascular disease and diabetes. There is paucity of data on cellular signal transduction…”
Get more information

Abstract 3842: Potent antitumor activity of the HSP90 inhibitor SNX-2112 in type 1 papillary renal cell carcinoma by Pahwa, Roma, Giri, Abhigya, Sourbier, Carole, Thomas, Craig, Linehan, W Marston, Neckers, Len, Srinivasan, Ramaprasad

“…Papillary renal-cell carcinoma (pRCC) is the second most common form of kidney cancer, accounting for 15 to 20% of all cases. There are currently no treatment…”
Get full text