ABCA1 gene R1587K polymorphism could be associated with metabolic syndrome and increased plasma triglyceride concentration in adults from northern Mexico

Objectives: to investigate the relationship of R1587K genotypes with cardiovascular (CV) risk, metabolic syndrome (MetS), lipid profile, paraoxonase-1 (PON1) activity, and anti-oxLDL titers. Methods: we performed a cross-sectional study in 57 northern Mexican adults with no reported diseases. The AB...

Full description

Saved in:

Bibliographic Details
Published in:	Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Vol. 37; no. 5; pp. 944 - 950
Main Authors:	Porchas Quijada, Mildren, Reyes Castillo, Zyanya, Román Pellegrini, Oney, Artalejo Ochoa, Elizabeth, Moya Camarena, Silvia Yolanda, Montalvo Corral, Maricela, Ballesteros Vásquez, Martha Nydia
Format:	Journal Article
Language:	English
Published:	Spain Grupo Arán 21-10-2020
Subjects:	Adult Aryldialkylphosphatase - blood ATP Binding Cassette Transporter 1 - genetics Blood Glucose - analysis Body Composition - genetics Cross-Sectional Studies DNA - genetics Female Gene Frequency Genotype Heart Disease Risk Factors Humans Insulin - blood Lipids - blood Male Metabolic Syndrome - epidemiology Metabolic Syndrome - genetics Mexico - epidemiology Middle Aged Nutrition & Dietetics Polymorphism, Genetic Polymorphism, Single Nucleotide Triglycerides - blood Young Adult Mexico Polimorfismo rs2230808. Enfermedades cardiovasculares. Paraoxonasa 1. Anticuerpos anti-oxLDL. Hipertrigliceridemia Hipertrigliceridemia Anticuerpos anti-oxLDL Paraoxonasa 1 Paraoxonase-1 Hypertriglyceridemia Enfermedades cardiovasculares Polimorfismo rs2230808 rs2230808 polymorphism Cardiovascular diseases anti-oxLDL antibodies R1587K
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Objectives: to investigate the relationship of R1587K genotypes with cardiovascular (CV) risk, metabolic syndrome (MetS), lipid profile, paraoxonase-1 (PON1) activity, and anti-oxLDL titers. Methods: we performed a cross-sectional study in 57 northern Mexican adults with no reported diseases. The ABCA1 R1587K SNP was detected by real-time polymerase chain reaction (qPCR) using TaqMan allelic discrimination probes. We evaluated the relationship of R1587K with metabolic syndrome and clinical parameters including lipid profile, glucose and insulin, PON1 activity and concentration, anti-oxLDL antibodies, anthropometry and body-composition parameters, and the atherogenic index of plasma calculation. Results: our results show higher triglyceride levels in the RK + KK carriers as compared to RR carriers (p = 0.031). An association between the RK + KK genotype and the presence of MetS (OR = 4.566, 95% CI = 1.386-14.92, p = 0.010) and a tendency towards high CV risk (OR = 3.317, 95% CI = 0.910-8.611, p = 0.069) was observed in comparison to RR carriers; however, there were no differences in HDL-C levels, PON1 activity and concentration, and anti-oxLDL titers among the R1587K genotypes. Conclusions: in the northern Mexican population, the ABCA1 gene R1587K SNP is present and the RK + KK genotypes are associated with MetS and increased triglyceride concentrations; therefore, it could be a CV risk biomarker. Nevertheless there is a need for further confirmation in longitudinal studies.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0212-1611 1699-5198 1699-5198
DOI:	10.20960/nh.03087