Search Results - "Rollins, Scott"

Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease by Ataga, Kenneth I, Kutlar, Abdullah, Kanter, Julie, Liles, Darla, Cancado, Rodolfo, Friedrisch, João, Guthrie, Troy H, Knight-Madden, Jennifer, Alvarez, Ofelia A, Gordeuk, Victor R, Gualandro, Sandra, Colella, Marina P, Smith, Wally R, Rollins, Scott A, Stocker, Jonathan W, Rother, Russell P

“…In this yearlong trial involving patients with sickle cell disease, crizanlizumab, an antibody to P-selectin, was associated with a 45% lower rate of pain…”
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Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria by Rother, Russell P, Rollins, Scott A, Mojcik, Christopher F, Brodsky, Robert A, Bell, Leonard

“…The complement system provides critical immunoprotective and immunoregulatory functions but uncontrolled complement activation can lead to severe pathology. In…”
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The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria by Hillmen, Peter, Young, Neal S, Schubert, Jörg, Brodsky, Robert A, Socié, Gerard, Muus, Petra, Röth, Alexander, Szer, Jeffrey, Elebute, Modupe O, Nakamura, Ryotaro, Browne, Paul, Risitano, Antonio M, Hill, Anita, Schrezenmeier, Hubert, Fu, Chieh-Lin, Maciejewski, Jaroslaw, Rollins, Scott A, Mojcik, Christopher F, Rother, Russell P, Luzzatto, Lucio

“…In this randomized trial, eculizumab, a humanized monoclonal antibody against C5 that inhibits terminal complement activation, was compared with placebo as a…”
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Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria by Hillmen, Peter, Muus, Petra, Dührsen, Ulrich, Risitano, Antonio M., Schubert, Jörg, Luzzatto, Lucio, Schrezenmeier, Hubert, Szer, Jeffrey, Brodsky, Robert A., Hill, Anita, Socié, Gerard, Bessler, Monica, Rollins, Scott A., Bell, Leonard, Rother, Russell P., Young, Neal S.

“…Hemolysis and hemoglobinemia contribute to serious clinical sequelae in hemolytic disorders. In paroxysmal nocturnal hemoglobinuria (PNH) patients, hemolysis…”
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Effect of Eculizumab on Hemolysis and Transfusion Requirements in Patients with Paroxysmal Nocturnal Hemoglobinuria by Hillmen, Peter, Hall, Claire, Marsh, Judith C.W, Elebute, Modupe, Bombara, Michael P, Petro, Beth E, Cullen, Matthew J, Richards, Stephen J, Rollins, Scott A, Mojcik, Christopher F, Rother, Russell P

“…The cause of the hemolytic anemia of paroxysmal nocturnal hemoglobinuria (PNH) is excessive susceptibility of erythrocytes to the lytic effects of the…”
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A Framework for Developing Ecosystem-Specific Nutrient Criteria: Integrating Biological Thresholds with Predictive Modeling by Soranno, Patricia A., Cheruvelil, Kendra Spence, Stevenson, R. Jan, Rollins, Scott L., Holden, Sarah W., Heaton, Sylvia, Torng, Eric

“…We present a novel ecosystem-specific framework for developing nutrient criteria from biological thresholds and predictive modeling (BTPM) and an application…”
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Creation and Expansion of a Mixed Patient Intermediate Care Unit to Improve ICU Capacity by Kistler, Emmett A, Klatt, Elaine, Raffa, Jesse D, West, Phyllis, Fitzgerald, Jacqueline A, Barsamian, Jennifer, Rollins, Scott, Clements, Charlotte M, Hickox Murray, Shelby, Cocchi, Michael N, Yang, Julius, Hayes, Margaret M

“…ICU capacity strain is associated with worsened outcomes. Intermediate care units (IMCs) comprise one potential option to offload ICUs while providing…”
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Terminal Complement Blockade With Pexelizumab During Coronary Artery Bypass Graft Surgery Requiring Cardiopulmonary Bypass: A Randomized Trial by Verrier, Edward D, Shernan, Stanton K, Taylor, Kenneth M, Van de Werf, Frans, Newman, Mark F, Chen, John C, Carrier, Michel, Haverich, Axel, Malloy, Kevin J, Adams, Peter X, Todaro, Thomas G, Mojcik, Christopher F, Rollins, Scott A, Levy, Jerrold H, for the PRIMO-CABG Investigators

“…CONTEXT Inflammation and ischemia-reperfusion injury during coronary artery bypass graft (CABG) surgery requiring cardiopulmonary bypass are associated with…”
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Complement Activation after Oxidative Stress : Role of the Lectin Complement Pathway by Collard, Charles D, Vakeva, Antti, Morrissey, Margaret A, Agah, Azin, Rollins, Scott A, Reenstra, Wende R, Buras, Jon A, Meri, Seppo, Stahl, Gregory L

“…The complement system plays an important role in mediating tissue injury after oxidative stress. The role of mannose-binding lectin (MBL) and the lectin…”
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Amelioration of Lupus-Like Autoimmune Disease in NZB/W F1 Mice after Treatment with a Blocking Monoclonal Antibody Specific for Complement Component C5 by Wang, Yi, Hu, Qile, Madri, Joseph A., Rollins, Scott A., Chodera, Amy, Matis, Louis A.

“…New Zealand black × New Zealand white (NZB/W) F1 mice spontaneously develop an autoimmune syndrome with notable similarities to human systemic lupus…”
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Myocardial infarction and apoptosis after myocardial ischemia and reperfusion : Role of the terminal complement components and inhibition by anti-C5 therapy by VAKEVA, A. P, AGAH, A, ROLLINS, S. A, MATIS, L. A, LAN LI, STAHL, G. L

“…Myocardial ischemia and reperfusion (MI/R)-induced tissue injury involves necrosis and apoptosis. However, the precise contribution of apoptosis to cell death,…”
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Impact of pexelizumab, an anti-C5 complement antibody, on total mortality and adverse cardiovascular outcomes in cardiac surgical patients undergoing cardiopulmonary bypass by Shernan, Stanton K, Fitch, Jane C.K, Nussmeier, Nancy A, Chen, John C, Rollins, Scott A, Mojcik, Christopher F, Malloy, Kevin J, Todaro, Thomas G, Filloon, Thomas, Boyce, Steven W, Gangahar, Deepak M, Goldberg, Michael, Saidman, Lawrence J, Mangano, Dennis T

“…During cardiac surgery requiring cardiopulmonary bypass, pro-inflammatory complement pathways are activated by exposure of blood to bio-incompatible surfaces…”
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Anti-C5 Monoclonal Antibody Therapy Prevents Collagen-Induced Arthritis and Ameliorates Established Disease by Wang, Yi, Rollins, Scott A., Madri, Joseph A., Matis, Louis A.

“…Activated components of the complement system are potent mediators of inflammation that may play an important role in numerous disease states. For example,…”
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Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis by Sandrin, Mauro S, Fodor, William L, Mouthtouris, Effie, Osman, Narin, Cohney, Shlomo, Rollins, Scott A, Guilmette, Edward R, Setter, Eva, Squinto, Stephen P, Mckenzie, Ian F.C

“…The major obstacle to successful discordant xenotransplantation is the phenomenon of hyperacute rejection (HAR). In the pig-to-primate discordant transplant…”
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Prognostic usefulness of white blood cell count and temperature in acute myocardial infarction (from the CARDINAL Trial) by Patel, Manesh R., Mahaffey, Kenneth W., Armstrong, Paul W., Weaver, W. Douglas, Tasissa, Gudaye, Hochman, Judith S., Todaro, Thomas G., Malloy, Kevin J., Rollins, Scott, Theroux, Pierre, Ruzyllo, Witold, Nicolau, Jose C., Granger, Christopher B.

“…White blood cell (WBC) count and temperature are 2 global measures of inflammation that are systematically gathered and easily identifiable in a clinical…”
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Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation by Rinder, Christine S., Rinder, Henry M., Smith, Michael J., Fitch, Jane C.K., Tracey, Jayne B., Chandler, Wayne L., Rollins, Scott A., Smith, Brian R.

“…BACKGROUND:  Patients undergoing cardiac surgery requiring cardiopulmonary bypass develop a systemic inflammatory reaction. Antithrombin III (AT) has…”
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Serum complement activation in congestive heart failure by Clark, David J., Cleman, Michael W., Pfau, Steven E., Rollins, Scott A., Ramahi, Tarik M., Mayer, Craig, Caulin-Glaser, Teresa, Daher, Edouard, Kosiborod, Mikhail, Bell, Leonard, Setaro, John F.

“…Background Although activation of the complement system in myocardial infarction and cardiopulmonary bypass has been shown to contribute to myocardial injury,…”
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Development and application of an algae multi-metric index to inform ecologically relevant nitrogen reduction targets by Rollins, Scott L., Ritz, Charles, Krone, Pam, Stevenson, R. Jan, Pan, Yangdong, Gillett, Nadia, Los Huertos, Marc

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Elevating Nursing Leadership by Rollins, Scott, Porter-O’Grady, Tim, Bailey, K. David

“…Nursing leadership demands a transformative shift towards fostering ownership, accountability, and excellence. Historically hindered by hierarchical…”
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Complement-specific antibodies: Designing novel anti-inflammatories by Matis, Louis A, Rollins, Scott A

“…The immunoglobulin variable gene repertoire generates enormous diversity through both combinatorial and somatic mutational mechanisms. Consequently, it has the…”
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