Search Results - "Rollins, Jarod A"
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Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity
Published in Cell reports (Cambridge) (23-07-2019)“…Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6…”
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Assessing Health Span in Caenorhabditis elegans: Lessons From Short-Lived Mutants
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01-04-2017)“…Genetic changes resulting in increased life span are often positively associated with enhanced stress resistance and somatic maintenance. A recent study found…”
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GLH-1/Vasa represses neuropeptide expression and drives spermiogenesis in the C. elegans germline
Published in Developmental biology (01-12-2022)“…Germ granules harbor processes that maintain germline integrity and germline stem cell capacity. Depleting core germ granule components in C. elegans leads to…”
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Variation at the vernalisation genes Vrn-H1 and Vrn-H2 determines growth and yield stability in barley (Hordeum vulgare) grown under dryland conditions in Syria
Published in Theoretical and applied genetics (01-11-2013)“…KEY MESSAGE : Spring growth in barley controlled by natural variation at Vrn-H1 and Vrn-H2 improved yield stability in marginal Syrian environments. The…”
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Fluorescent Polysome Profiling in Caenorhabditis elegans
Published in Bio-protocol (05-09-2020)“…An important but often overlooked aspect of gene regulation occurs at the level of protein translation. Many genes are regulated not only by transcription but…”
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Dietary restriction induces posttranscriptional regulation of longevity genes
Published in Life science alliance (01-08-2019)“…Dietary restriction (DR) increases life span through adaptive changes in gene expression. To understand more about these changes, we analyzed the transcriptome…”
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Quantification of tissue-specific protein translation in whole C. elegans using O-propargyl-puromycin labeling and fluorescence microscopy
Published in Cell reports methods (25-04-2022)“…The regulation of gene expression via protein translation is critical for growth, development, and stress response. While puromycin-based techniques have been…”
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The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans
Published in eLife (08-12-2020)“…Our knowledge about the repertoire of ribosomal RNA modifications and the enzymes responsible for installing them is constantly expanding. Previously, we…”
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Single and interacting QTLs for cholesterol gallstones revealed in an intercross between mouse strains NZB and SM
Published in Mammalian genome (01-03-2005)“…Quantitative trait locus (QTL) mapping was employed to investigate the genetic determinants of cholesterol gallstone formation in a large intercross between…”
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Quantitative Trait Loci That Determine BMD in C57BL/6J and 129S1/SvImJ Inbred Mice
Published in Journal of bone and mineral research (01-01-2006)“…BMD is highly heritable; however, little is known about the genes. To identify loci controlling BMD, we conducted a QTL analysis in a (B6 × 129) F2 population…”
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THE ROLE OF RIBOSOMAL COMPOSITION IN SELECTIVE TRANSLATION OF LONGEVITY GENES UNDER DIETARY RESTRICTION
Published in Innovation in aging (08-11-2019)“…Abstract Dietary restriction influences longevity through changes in gene expression on the level of transcription and translation. Our lab is investigating…”
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Characterization of ribosomal RNA methylations modulating life- and healthspan of Caenorhabditis elegans
Published in Experimental gerontology (01-08-2017)Get full text
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The ribosomal RNA m.sup.5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans
Published in eLife (08-12-2020)“…Our knowledge about the repertoire of ribosomal RNA modifications and the enzymes responsible for installing them is constantly expanding. Previously, we…”
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The ribosomal RNA m 5 C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans
Published in eLife (08-12-2020)“…Our knowledge about the repertoire of ribosomal RNA modifications and the enzymes responsible for installing them is constantly expanding. Previously, we…”
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Quantitative trait loci that determine BMD in C57BL/6J and 129Sl/SvImJ inbred mice
Published in Journal of bone and mineral research (2006)Get full text
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