Search Results - "Rollins, Jarod"

Fluorescent Polysome Profiling in Caenorhabditis elegans by Shaffer, Daniel, Rollins, Jarod A

“…An important but often overlooked aspect of gene regulation occurs at the level of protein translation. Many genes are regulated not only by transcription but…”
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Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity by Lan, Jianfeng, Rollins, Jarod A., Zang, Xiao, Wu, Di, Zou, Lina, Wang, Zi, Ye, Chang, Wu, Zixing, Kapahi, Pankaj, Rogers, Aric N., Chen, Di

“…Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6…”
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Assessing Health Span in Caenorhabditis elegans: Lessons From Short-Lived Mutants by Rollins, Jarod A, Howard, Amber C, Dobbins, Sarah K, Washburn, Elsie H, Rogers, Aric N

“…Genetic changes resulting in increased life span are often positively associated with enhanced stress resistance and somatic maintenance. A recent study found…”
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GLH-1/Vasa represses neuropeptide expression and drives spermiogenesis in the C. elegans germline by Rochester, Jesse D., Min, Hyemin, Gajjar, Gita A., Sharp, Catherine S., Maki, Nathaniel J., Rollins, Jarod A., Keiper, Brett D., Graber, Joel H., Updike, Dustin L.

“…Germ granules harbor processes that maintain germline integrity and germline stem cell capacity. Depleting core germ granule components in C. elegans leads to…”
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Variation at the vernalisation genes Vrn-H1 and Vrn-H2 determines growth and yield stability in barley (Hordeum vulgare) grown under dryland conditions in Syria by Rollins, Jarod A, Drosse, B, Mulki, M. A, Grando, S, Baum, M, Singh, M, Ceccarelli, S, von Korff, M

“…KEY MESSAGE : Spring growth in barley controlled by natural variation at Vrn-H1 and Vrn-H2 improved yield stability in marginal Syrian environments. The…”
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SR Protein Family Members Display Diverse Activities in the Formation of Nascent and Mature mRNPs In Vivo by Sapra, Aparna K., Änkö, Minna-Liisa, Grishina, Inna, Lorenz, Mike, Pabis, Marta, Poser, Ina, Rollins, Jarod, Weiland, Eva-Maria, Neugebauer, Karla M.

“…The SR proteins are a family of pre-mRNA splicing factors with additional roles in gene regulation. To investigate individual family members in vivo, we…”
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Dietary restriction induces posttranscriptional regulation of longevity genes by Rollins, Jarod A, Shaffer, Dan, Snow, Santina S, Kapahi, Pankaj, Rogers, Aric N

“…Dietary restriction (DR) increases life span through adaptive changes in gene expression. To understand more about these changes, we analyzed the transcriptome…”
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Quantification of tissue-specific protein translation in whole C. elegans using O-propargyl-puromycin labeling and fluorescence microscopy by Somers, Hannah M., Fuqua, Jeremy H., Bonnet, Frédéric X.A., Rollins, Jarod A.

“…The regulation of gene expression via protein translation is critical for growth, development, and stress response. While puromycin-based techniques have been…”
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The integrated stress response protects against ER stress but is not required for altered translation and lifespan from dietary restriction in Caenorhabditis elegans by Ma, Zhengxin, Horrocks, Jordan, Mir, Dilawar A, Cox, Matthew, Ruzga, Marissa, Rollins, Jarod, Rogers, Aric N

“…The highly conserved integrated stress response (ISR) reduces and redirects mRNA translation in response to certain forms of stress and nutrient limitation. It…”
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orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development by Matteson, Paul G, Desai, Jigar, Korstanje, Ron, Lazar, Gloria, Borsuk, Tanya E, Rollins, Jarod, Kadambi, Sindhuja, Joseph, Jamie, Rahman, Taslima, Wink, Jason, Benayed, Rym, Paigen, Beverly, Millonig, James H

“…The vacuolated lens (vl) mouse mutant causes congenital cataracts and neural tube defects (NTDs), with the NTDs being caused by abnormal neural fold apposition…”
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The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans by Heissenberger, Clemens, Rollins, Jarod A, Krammer, Teresa L, Nagelreiter, Fabian, Stocker, Isabella, Wacheul, Ludivine, Shpylovyi, Anton, Tav, Koray, Snow, Santina, Grillari, Johannes, Rogers, Aric N, Lafontaine, Denis L J, Schosserer, Markus

“…Our knowledge about the repertoire of ribosomal RNA modifications and the enzymes responsible for installing them is constantly expanding. Previously, we…”
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Ribosomal Protein 6 Phosphorylation Regulates Translational Responses to Dietary Restriction by Rollins, Jarod

“…Abstract Forms of dietary restriction like intermittent fasting (IF) and caloric restriction (CR) promote health and longevity through changes in gene…”
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Quantitative Trait Loci That Determine BMD in C57BL/6J and 129S1/SvImJ Inbred Mice by Ishimori, Naoki, Li, Renhua, Walsh, Kenneth A, Korstanje, Ron, Rollins, Jarod A, Petkov, Petko, Pletcher, Mathew T, Wiltshire, Tim, Donahue, Leah Rae, Rosen, Clifford J, Beamer, Wesley G, Churchill, Gary A, Paigen, Beverly

“…BMD is highly heritable; however, little is known about the genes. To identify loci controlling BMD, we conducted a QTL analysis in a (B6 × 129) F2 population…”
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Locating Ath8, a locus for murine atherosclerosis susceptibility and testing several of its candidate genes in mice and humans by Korstanje, Ron, Eriksson, Per, Samnegård, Ann, Olsson, Per G., Forsman-Semb, Kristina, Sen, Saunak, Churchill, Gary A., Rollins, Jarod, Harris, Stephen, Hamsten, Anders, Paigen, Beverly

“…A previous study revealed that the difference in susceptibility to atherosclerotic lesions between inbred mouse strains SM/J and NZB/BlNJ was determined by one…”
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Single and interacting QTLs for cholesterol gallstones revealed in an intercross between mouse strains NZB and SM by Lyons, Malcolm A, Korstanje, Ron, Li, Renhua, Sheehan, Susan M, Walsh, Kenneth A, Rollins, Jarod A, Carey, Martin C, Paigen, Beverly, Churchill, Gary A

“…Quantitative trait locus (QTL) mapping was employed to investigate the genetic determinants of cholesterol gallstone formation in a large intercross between…”
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THE ROLE OF RIBOSOMAL COMPOSITION IN SELECTIVE TRANSLATION OF LONGEVITY GENES UNDER DIETARY RESTRICTION by Rollins, Jarod A

“…Abstract Dietary restriction influences longevity through changes in gene expression on the level of transcription and translation. Our lab is investigating…”
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In silico identification of anti-aging pharmaceutics from community knowledge by Beck, Samuel, Lee, Jun-Yeong, Rollins, Jarod

“…Abstract In this era of Big Data, the volume of biological data is growing exponentially. Systematic profiling and analysis of these data will provide a new…”
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Erratum: Loss of eif-2alpha phosphorylation on S49 (mammalian S51) associated with the integrated stress response hastens development in C. elegans

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Reducing translation through eIF4G/IFG‐1 improves survival under ER stress that depends on heat shock factor HSF‐1 in Caenorhabditis elegans by Howard, Amber C., Rollins, Jarod, Snow, Santina, Castor, Sarah, Rogers, Aric N.

“…Summary Although certain methods of lowering and/or altering mRNA translation are associated with increased lifespan, the mechanisms underlying this effect…”
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Characterization of ribosomal RNA methylations modulating life- and healthspan of Caenorhabditis elegans by Schosserer, Markus, Rollins, Jarod A., Heissenberger, Clemens, Nagelreiter, Fabian, Snow, Santina, Rogers, Aric, Grillari, Johannes

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