The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas

Bryostatin 1 is a protein kinase C modulator that shows antineoplastic activity in a variety of tumor systems. This study examined the effects of bryostatin 1 administration on papilloma growth in rabbits. Investigations of optimal route, dose, and schedule were performed. Several groups of rabbits...

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Bibliographic Details
Published in:	Cancer letters Vol. 136; no. 1; pp. 67 - 74
Main Authors:	Bodily, Jason M, Hoopes, David J, Roeder, Beverly L, Gilbert, Sharon G, Pettit, George R, Herald, Cherry L, Rollins, Darin N, Robison, Richard A
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 08-02-1999 Elsevier
Subjects:	Animals Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Biological and medical sciences Bryostatin 1 Bryostatins Cancer therapeutics Catheters, Indwelling Cervical cancer Chemotherapy Cottontail rabbit papillomavirus Drug Administration Schedule Female Infusions, Intravenous Injections, Intralesional Lactones - administration & dosage Lactones - pharmacology Macrolides Medical sciences Papilloma - drug therapy Papilloma - virology Papillomavirus Pharmacology. Drug treatments PKC Rabbits Papillomavirus PKC Bryostatin 1 Cancer therapeutics Cervical cancer Antineoplastic agent Animal model Protein kinase C Intravenous administration Enzyme Toxicity Transferases Rabbit Papovaviridae Lagomorpha Cottontail rabbit papillomavirus Biological activity Virus Vertebrata Chemotherapy Mammalia Treatment Animal Tumor progression Papilloma Benign neoplasm
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Summary:	Bryostatin 1 is a protein kinase C modulator that shows antineoplastic activity in a variety of tumor systems. This study examined the effects of bryostatin 1 administration on papilloma growth in rabbits. Investigations of optimal route, dose, and schedule were performed. Several groups of rabbits were inoculated with cottontail rabbit papillomavirus (CRPV) DNA. Bryostatin 1 was administered i.v., both daily and weekly, and intralesionally both weekly and bi-weekly. Intralesionally dosed papillomas were examined histologically for immune cell infiltration. In weekly and daily i.v. trials, 2.5 and 1.0 μg/kg, respectively, showed the greatest overall reduction in tumor size. Bryostatin 1 administered intralesionally also slowed papilloma growth. Treated lesions had significantly higher numbers of heterophils and eosinophils.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-3835 1872-7980
DOI:	10.1016/S0304-3835(98)00310-3